scholarly journals Serum Albumin and Future Risk of Hip, Humeral, and Wrist Fractures in Caucasian Men: New Findings from a Prospective Cohort Study

2019 ◽  
Vol 28 (5) ◽  
pp. 401-409 ◽  
Author(s):  
Setor K. Kunutsor ◽  
Ari Voutilainen ◽  
Michael R. Whitehouse ◽  
Samuel Seidu ◽  
Jussi Kauhanen ◽  
...  
Keyword(s):  
Serum Albumin ◽  
Area Under The Curve ◽  
Fracture Prevention ◽  
Albumin Concentration ◽  
Serum Albumin Concentration ◽  
Baseline Serum ◽  
Increased Risk ◽  
New Findings ◽  
Caucasian Men ◽  
Low Serum

Objective: Low serum albumin concentration is associated with poor health outcomes, but its relationship with the risk of fractures has not been reliably quantified. We aimed to assess the prospective association of serum albumin with the risk of fractures in a general population. Subjects and Methods: Baseline serum albumin concentrations were measured in 2,245 men aged 42–61 years in the Kuopio Is­chemic Heart Disease study. Hazard ratios (HRs) (95% confidence intervals) were calculated for incident fractures. Results: A total of 121 fractures (hip, humeral, or wrist) were recorded during a median follow-up of 25.6 years. The risk of fractures increased linearly below a serum albumin concentration of ∼48 g/L. The age-adjusted HR (95% CI) for fractures per 1 standard deviation lower serum albumin was 1.24 (1.05–1.48). On further adjustment for several conventional and emerging risk factors, the HR was attenuated to 1.21 (1.01–1.45). Comparing the bottom versus top quartile of serum albumin levels, the corresponding adjusted HRs were 2.48 (1.37–4.48) and 2.26 (1.23–4.14). The association of serum albumin with fracture risk did not differ substantially according to age, body mass index, blood pressure, physical activity, alcohol consumption, socioeconomic status, inflammation, prevalent diseases, and smoking. Serum albumin at a threshold of 41.5 g/L demonstrated an area under the curve of 0.5850. Conclusion: In middle-aged Caucasian men, low serum albumin is associated with an increased risk of future fractures. The potential relevance of serum albumin concentrations in fracture prevention and prediction deserves further evaluation.

Low serum albumin concentration predicts the need for surgical intervention in neonates with necrotizing enterocolitis

2020 ◽  
Vol 55 (12) ◽  
pp. 2625-2629
Author(s):  
Shazia P. Sharif ◽  
Florian Friedmacher ◽  
Amir Amin ◽  
Rafdzah A. Zaki ◽  
Michael F. Hird ◽  
...  
Keyword(s):  
Serum Albumin ◽  
Necrotizing Enterocolitis ◽  
Surgical Intervention ◽  
Albumin Concentration ◽  
Serum Albumin Concentration ◽  
Low Serum

Pharmacokinetics of Cerivastatin in Renal Impairment Are Predicted by Low Serum Albumin Concentration Rather Than by Low Creatinine Clearance

1999 ◽  
Vol 39 (2) ◽  
pp. 147-154 ◽  
Author(s):  
Stefan V. Vormfelde ◽  
Wolfgang Mück ◽  
Stefan M. Freudenthaler ◽  
Petra Heyen ◽  
Nikolaus Schmage ◽  
...  
Keyword(s):  
Renal Impairment ◽  
Serum Albumin ◽  
Creatinine Clearance ◽  
Albumin Concentration ◽  
Serum Albumin Concentration ◽  
Low Serum

Plasma Selenium Concentrations in Patients with Euthyroid Sick Syndrome

1992 ◽  
Vol 38 (9) ◽  
pp. 1885-1888 ◽  
Author(s):  
F Van Lente ◽  
R Daher
Keyword(s):  
Serum Albumin ◽  
Selenium Concentration ◽  
Selenium Supplementation ◽  
Molar Ratio ◽  
Albumin Concentration ◽  
Serum Albumin Concentration ◽  
Selenium Status ◽  
Euthyroid Sick Syndrome ◽  
Plasma Selenium ◽  
Low Serum

Abstract We evaluated plasma selenium concentrations in patients with euthyroid sick syndrome express by low serum triiodothyronine (T3) concentrations. Selenium status in these patients was compared with that found in patients with both untreated and treated hypothyroidism. Selenium concentrations in plasma were significantly lower in hospitalized patients with either euthyroid sick syndrome (0.99 +/- 0.37 mumol/L) or treated hypothyroidism (1.09 +/- 0.25 mumol/L) than in patients with untreated hypothyroidism (1.39 +/- 0.28 mumol/L). However, there was no significant, independent relationship between selenium and the thyroid function indices determined in this study. The strongest association was between serum albumin concentration and either selenium (r = 0.65), T3 (r = 0.58), or the molar ratio of T3 to thyroxine (r = 0.64). The decreased average selenium concentration appears to be associated with the hypercatabolic state of severely ill patients, as indicated by the serum albumin concentration; these patients should be considered for selenium supplementation and their selenium status should be monitored.

scholarly journals Serum albumin and risk of venous thromboembolism

2010 ◽  
Vol 104 (07) ◽  
pp. 100-104 ◽  
Author(s):  
Pamela L. Lutsey ◽  
Susan R. Heckbert ◽  
Mary Cushman ◽  
Aaron R. Folsom
Keyword(s):  
Venous Thromboembolism ◽  
Serum Albumin ◽  
Cardiovascular Health ◽  
Hormone Replacement ◽  
Hazard Ratio ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Albumin Concentration ◽  
Increased Risk ◽  
Low Serum

SummaryThe incidence of venous thromboembolism (VTE) is increased in patients with albuminuria. However, whether a low serum albumin concentration is associated with increased risk of VTE has been a matter of controversy. We determined the association of serum albumin with VTE incidence in two large, prospective, population-based cohorts: the Atherosclerosis Risk in Communities (ARIC) Study (n = 15,300) and the Cardiovascular Health Study (CHS) (n = 5,400). Validated VTE occurrence (n = 462 in ARIC and n = 174 in CHS) was ascertained during follow-up. In both studies, after adjustment for age, sex, race, use of hormone replacement therapy, estimated glomerular filtration rate, history of cancer, and diabetes, serum albumin tended to be associated inversely with VTE. The adjusted hazard ratio per standard deviation lower albumin was 1.18 (95% confidence interval [CI] = 1.08, 1.31) in ARIC and 1.10 (95% CI = 0.94, 1.29) in CHS. The hazard ratio for albumin below (vs. above) the fifth percentile was 1.28 (95% CI = 0.90, 1.84) in ARIC and 1.80 (95% CI = 1.11, 2.93) in CHS. In conclusion, low serum albumin was a modest marker of increased VTE risk. The observed association likely does not reflect cause and effect, but rather that low serum albumin reflects a hyperinflammatory or hypercoagulable state. Whether this association has clinical relevance warrants further study.

Is There a Role for Albumin Administration in Nutrition Support?

1994 ◽  
Vol 28 (4) ◽  
pp. 478-482 ◽  
Author(s):  
Richard G. D'Angio
Keyword(s):  
Serum Albumin ◽  
Case Reports ◽  
Nutrition Support ◽  
Controlled Trials ◽  
Albumin Concentration ◽  
Serum Albumin Concentration ◽  
Medline Search ◽  
Albumin Administration ◽  
Routine Administration ◽  
Low Serum

OBJECTIVE: To review the administration of exogenous albumin in patients receiving nutritional support and determine if the use of albumin is supported by controlled trials. DATA SOURCES: MEDLINE search of English-language literature using the key terms albumin, parenteral nutrition, and enteral nutrition. The references of articles identified were also searched. STUDY SELECTION: Studies examining the administration of exogenous albumin to hypoalbuminemic patients receiving nutrition support. DATA EXTRACTION: Results from prospective randomized trials are presented in detail. Data from noncontrolled and animal studies are presented in areas where human controlled trials are limited. DATA SYNTHESIS: Albumin is a marker of malnutrition and numerous studies have demonstrated that a low serum albumin concentration is associated with increased morbidity and mortality. Investigators have attempted to improve outcome through the administration of exogenous albumin. The results of controlled trials examining exogenous albumin administration have been equivocal. One study demonstrated a significant decrease in overall complications, pneumonia, and sepsis. In two other controlled trials, albumin administration failed to decrease complications. None of the studies demonstrated a significant decrease in mortality or length of stay. A low serum albumin concentration has also been linked to intolerance to enteral feedings. Although case reports and one study support the administration of albumin, two prospective controlled trials have failed to demonstrate improved tolerance to enteral feeding in hypoalbuminemic patients receiving exogenous albumin. CONCLUSIONS: Evidence to date is insufficient to support the routine administration of exogenous albumin to hypoalbuminemic patients receiving nutrition support.

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