Randomized clinical trial on the effect of a supervised exercise program on quality of life, fatigue, and fitness following esophageal cancer treatment (PERFECT study).

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. 12055-12055
Author(s):  
Anne Maria May ◽  
Jonna van Vulpen ◽  
Anouk E Hiensch ◽  
Jelle P. Ruurda ◽  
Grard Nieuwenhuijzen ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Clinical Trial ◽  
Esophageal Cancer ◽  
Cardiorespiratory Fitness ◽  
Exercise Intervention ◽  
Exercise Program ◽  
Post Intervention ◽  
Supervised Exercise ◽  
Supervised Exercise Program

12055 Background: Patients with potentially curable esophageal cancer are often treated with chemoradiotherapy followed by surgery. This treatment might have a negative impact on physical fitness, fatigue and quality of life (QoL). In patients with other types of cancer, evidence suggests that physical exercise reduces treatment related side effects. We investigated whether a supervised exercise program also beneficially affects QoL, fatigue and cardiorespiratory fitness (CRF) in patients after treatment for esophageal cancer. Methods: The multicenter PERFECT study randomly assigned patients in the first year after esophagectomy to an exercise intervention (EX) or usual care (UC) group. EX patients participated in a 12-week moderate to high intensity aerobic and resistance exercise program supervised by a physiotherapist. UC patients were advised to maintain their physical activity levels. Attendance and compliance with the exercise intervention protocol were retrieved from exercise logs. QoL (primary outcome, EORTC-QLQ-30, range 0-100), fatigue (MFI-20, range 4-20) and CRF (cardiopulmonary exercise testing) were assessed at baseline and after 12 weeks (post-intervention). The outcomes were analyzed as between-group differences using either linear mixed effects models or ANCOVA adjusted for baseline and stratification factors (i.e. sex, time since surgery, center), according to the intention-to-treat principle. Results: A total of 120 patients (age 64±8) were included and randomized to EX (n = 61) or UC (n = 59). Patients in the EX group participated in 96% (IQR:92-100%) of the supervised exercise sessions and compliance with all parts of the exercise program was high ( > 90%). Post-intervention, global QoL was not statistically different between groups, but significant (p < 0.05) beneficial EX effects were found for QoL-Summary scores (between-group difference 3.5, 95% CI 0.2;6.8) and QoL-role functioning (9.4, 1.3;17.5). Physical fatigue wat non-significantly lower in the EX group (-1.2; -2.6;0.1, p = 0.08). CRF was significantly higher (VO2peak (1.8 mL/min/kg, 0.6;3.0) following the EX intervention. Conclusions: Patients were well capable to complete an intensive supervised exercise program after esophageal cancer treatment, which led to small but significant improvements in several aspects of QoL and cardiorespiratory fitness. Our results suggest that supervised exercise is a beneficial addition to routine care of patients with esophageal cancer. Clinical trial information: NTR5045 .

scholarly journals How Does a Supervised Exercise Program Improve Quality of Life in Patients with Cancer? A Concept Mapping Study Examining Patients' Perspectives

2018 ◽  
Vol 24 (6) ◽  
Author(s):  
Maike G. Sweegers ◽  
Laurien M. Buffart ◽  
Wouke M. van Veldhuizen ◽  
Edwin Geleijn ◽  
Henk M.W. Verheul ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Concept Mapping ◽  
Exercise Program ◽  
Improve Quality ◽  
Mapping Study ◽  
Patients With Cancer ◽  
Supervised Exercise ◽  
Supervised Exercise Program

Quality of Life Benefits in Cancer Survivorship with Supervised Exercise

2009 ◽  
Vol 104 (2) ◽  
pp. 421-424 ◽  
Author(s):  
Matthew S. Wiggins ◽  
Emily M. Simonavice
Keyword(s):  
Quality Of Life ◽  
Cancer Survivors ◽  
Exercise Program ◽  
Well Being ◽  
Bicycle Ergometer ◽  
Physically Active ◽  
Cancer Support ◽  
Supervised Exercise ◽  
Supervised Exercise Program

To assess whether a supervised exercise program would benefit cancer survivors' perceived psychological well-being over the course of a 6-mo. program, 8 female and 2 male cancer survivors, ages 45 to 69 ( M = 56.2, SD = 8.1) were recruited into the program from a presentation given to a breast-cancer support group and by word of mouth. Activity sessions were two times per week and typically involved treadmill and bicycle ergometer time, plus eight to ten weight-training stations. A quality of life measure was taken at baseline, 3, and 6 mo. Analyses showed a significant increase in quality of life from baseline to 3 mo. and from baseline to 6 mo. Being physically active in a supervised exercise program provided increased perceived benefits in quality of life for these cancer survivors over 6 mo.

All Patients Benefit Equally From a Supervised Exercise Program for Claudication

2007 ◽  
Vol 41 (3) ◽  
pp. 212-216 ◽  
Author(s):  
Ferdinand Serracino-Inglott ◽  
Gareth Owen ◽  
Andrew Carter ◽  
Francis Dix ◽  
John Vince Smyth ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Short Form ◽  
Exercise Program ◽  
Walking Distance ◽  
Supervised Exercise ◽  
Diabetic Status ◽  
Heterogenous Group ◽  
Cardiac Status ◽  
Supervised Exercise Program

This study assessed the effect of gender, diabetic status, statin use, smoking, hypertension, cardiac status, and use of cilostazol on the outcome of a supervised exercise program for patients with claudication. Patient risk factors were prospectively recorded in a group of patients who had completed 1 year on a supervised exercise program. In 165 claudicant patients, maximum walking distance increased ( P < .0001) from 67 meters (range, 17-196) to 122 meters (range, 43-409). Quality of life as measured by the Medical Outcome Study Short Form 36 increased ( P < .0001) from a median of 78 (range, 55-110) to 99 (range, 71-154). The improvements in claudication distance, maximal walking distance, and quality of life after the exercise program were not dependent on any of the measured patient factors. Patients referred to exercise programs for claudication are a heterogenous group. Despite this, they benefit equally from such a program.

Effect of Supervised Exercise Program on Individuals in Peripheral Arterial Disease with Type 2 Diabetes Mellitus - A Systematic Review

2020 ◽  
Vol 16 (3) ◽  
pp. 248-253
Author(s):  
Esha Arora ◽  
Arun G. Maiya ◽  
Tom Devasia ◽  
Rama Bhat ◽  
Ganesh Kamath
Keyword(s):  
Quality Of Life ◽  
Systematic Review ◽  
Ankle Brachial Index ◽  
Exercise Program ◽  
Arterial Disease ◽  
Supervised Exercise ◽  
Peripheral Arterial ◽  
Supervised Exercise Program

Background: Type 2 Diabetes Mellitus (T2DM) is usually accompanied by various micro and macro vascular complications. Peripheral Arterial Disease (PAD) is one of the major complications of diabetes which is accountable for morbidity and mortality throughout the world. The first line of treatment in these individuals is life style modification and exercise. There is a dearth of literature on effect of supervised exercise program in PAD with T2DM on quality of life, walking impairment, change in Ankle Brachial Index (ABI) values. So, we conducted a systematic review to explore the available literature on supervised exercise program in PAD with T2DM. Methods: We conducted a systematic review (PubMed, Web of Science, CINAHL and Cochrane) to summarise the evidence on a supervised exercise program in PAD with T2DM. Randomised and nonrandomised studies were included in the review. Results: Three studies met the inclusion criteria. The outcomes taken into accounts by the studies were the quality of life, walking impairment questionnaire, Ankle brachial index. Neither of the studies matched in their supervised exercise program nor in their outcome. Conclusion: In conclusion, the data evaluating the supervised exercise program in PAD with T2DM is inadequate to determine its effect on this population. Future large-scale studies can be conducted on both subjective and objective outcomes of PAD with T2DM to have a better understanding of the condition and for a universally acceptable exercise program for these individuals which the healthcare practitioners can use in their practice.

scholarly journals The effects of supervision on three different exercises modalities (supervised vs. home vs. supervised+home) in older adults: Randomized controlled trial protocol

PLoS ONE ◽  
2021 ◽  
Vol 16 (11) ◽  
pp. e0259827
Author(s):  
Sabrine Nayara Costa ◽  
Luis Henrique Boiko Ferreira ◽  
Paulo Cesar Barauce Bento
Keyword(s):  
Quality Of Life ◽  
Older Adults ◽  
Clinical Trial ◽  
Physical Function ◽  
Exercise Program ◽  
Secondary Outcome ◽  
Randomized Controlled ◽  
Supervised Exercise ◽  
Home Based

Background Multicomponent physical exercise programs are a viable strategy for treating physical decline resulting from the aging process in older populations and can be applied in supervised and home-based modalities. However, the magnitude of the intervention effects in terms of physical function development may vary according to the modalities application due to different supervision degrees. Objective This study aims to compare the effects of supervision in a multicomponent exercise program in different application modalities (supervised vs. home vs. supervised+home) in neuromuscular adaptations, muscle strength, gait, physical function, and quality of life, analyzing the differences between intensity, volume, and density of home and supervised sessions in community older adults. Methods This protocol is a randomized controlled clinical trial with a sample of 66 older adults divided into three groups: supervised exercise (SUP = 22), home-based exercise (HB = 22), and supervised plus home-based exercise (SUP+HB = 22). The multicomponent exercise program will last 12 weeks, three times per week, for 60 min per session and include warm-up, balance, muscle-strengthening, gait, and flexibility exercises. The study’s primary outcomes will be neuromuscular function, composed of the assessment of muscle isokinetic strength, muscle architecture, and neuromuscular electrical activation. The secondary outcome will be physical function, usual and maximum gait speed with and without dual-task, and quality of life. All outcomes will be assessed at baseline and post-intervention (week 12). Conclusion This study will be the first clinical trial to examine the effects of different supervision levels on home-based exercises compared to supervised protocols. The results of this study will be essentials for planning coherent and viable home-based programs for older adults. Trial registration Brazilian Registry of Clinical Trials. Number RBR- 7MZ2KR. https://apps.who.int/trialsearch/Trial2.aspx?TrialID=RBR-7mz2kr.

374 Cognitive Behavioral Therapy with Exercise in Adults with Insomnia and Short Sleep: Daytime Function Outcomes from a Pilot Study

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A149-A149
Author(s):  
Andrew Kubala ◽  
Mara Egeler ◽  
Daniel Buysse ◽  
Martica Hall ◽  
Emma Barinas-Mitchell ◽  
...  
Keyword(s):  
Sleep Duration ◽  
Behavioral Therapy ◽  
Exercise Program ◽  
Short Sleep Duration ◽  
Post Intervention ◽  
Short Sleep ◽  
Supervised Exercise ◽  
Daytime Function ◽  
Supervised Exercise Program ◽  
Insomnia Severity

Abstract Introduction Cognitive behavioral therapy for insomnia (CBT-I) is efficacious, but there is mixed evidence as to whether improvement is blunted in adults with insomnia and short sleep duration. Exercise training can reduce physiologic hyperarousal and may increase homeostatic sleep drive, which could potentiate CBT-I treatment effects. This pilot study explored changes in self-reported outcomes from a CBT-I intervention augmented by exercise training in a sample of adults with insomnia and objective short sleep duration. Methods Eight adults (50% female, 62.5% white) with insomnia disorder and short sleep duration (mean actigraphic TST &lt;6.5 hr) completed a 12-week single-arm trial. Participants self-administered the online “Sleep Healthy Using the Internet” (SHUT-I) CBT-I program with additional staff guidance while completing a supervised exercise program (EX; 150 min/wk of moderate-intensity aerobic exercise and 2 days/wk of strength training). Participants completed assessments of self-reported sleep and daytime function pre- and post-intervention, including the Insomnia Severity Index (ISI), Flinders Fatigue Scale (FFS), Ford Insomnia Response to Stress Test (FIRST), Perceived Stress Scale (PSS), and Epworth Sleepiness Scale (ESS). Differences between timepoints were analyzed using paired t-tests and Cohen’s d effect size calculations. Results Insomnia severity significantly decreased after the intervention (ISI: p&lt;0.001, d=2.99), with 75% reporting post-intervention ISI ≤ 7. Likewise, fatigue significantly decreased after the intervention (FFS: p=0.032, d=0.95). Symptoms of stress-related sleep reactivity and stress were also reduced (FIRST: p=0.012, d=1.19; PSS: p=0.014, d=1.14). Though nonsignificant, large reductions in sleepiness were additionally observed (ESS: p=0.058, d=0.80). Conclusion In this pilot trial among patients with insomnia and short sleep duration, online CBT-I plus a supervised exercise program resulted in a significant reduction in insomnia severity. The intervention also produced large and meaningful reductions in fatigue and stress, which are common daytime impairments in patients with insomnia. Future research should attempt to disentangle the independent contributions of CBT-I and exercise on outcomes in this population. Support (if any) NIH: K23HL118318

scholarly journals Effect of Baduanjin exercise intervention on cognitive function and quality of life in women with breast cancer receiving chemotherapy: study protocol of a randomized controlled trial

Trials ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Xiao-Lin Wei ◽  
Ru-Zhen Yuan ◽  
Yong-Mei Jin ◽  
Shu Li ◽  
Ming-Yue Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Clinical Trial ◽  
Cognitive Function ◽  
Exercise Intervention ◽  
Early Stage ◽  
Early Stage Breast Cancer ◽  
Pharmacological Intervention ◽  
Control Group

Abstract Background More than 50% cognitive impairment was reported by cancer patients before and after medical treatment. However, there are no effective interventions to manage the cognitive problem in women with breast cancer. This pilot study was designed to evaluate the protective effect of Baduanjin exercise on cognitive function and cancer-related symptoms in women with early-stage breast cancer undergoing chemotherapy. Method A single-blinded, randomized control trial was designed. The trial will recruit 70 patients with early-stage breast cancer scheduled to receive chemotherapy from Shanghai in China. All participants will be randomly assigned to (1:1) the supervised Baduanjin group (5 times/week, 30 min each time) or the wait-list control group for 3 months. The effect of Baduanjin exercise intervention will be evaluated by outcome measures including subjective and objective cognitive function, symptoms (fatigue, depression, and anxiety), and health-related quality of life at pre-intervention (T0), 8 weeks (T1), and 12 weeks (T2). The PCI score in the FACT-Cog as the primary cognitive outcome will be reported descriptively, while effect sizes and 95% confidence intervals (CIs) will be calculated. The collected data will be analyzed by using an intention-to-treat principle and linear mixed-effects modeling. Discussion This is the first randomized clinical trial to investigate whether Baduanjin exercise will have a positive role in improving cognitive function in women with breast cancer receiving chemotherapy. If possible, Baduanjin exercise will be a potential non-pharmacological intervention to manage cognitive dysfunction and promote survivorship care among breast cancer survivors. Trial registration Chinese Clinical Trial Registry (ChiCTR) ChiCTR2000033152. Registered on 22 May 2020

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