Specific organ metastases and survival of advanced non-small cell lung cancer (NSCLC) patients with EGFR mutation.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e21527-e21527
Author(s):  
Tiantian Shi ◽  
Long Wang ◽  
Zhisong Fan ◽  
Li Feng ◽  
Jing Han ◽  
...  
Keyword(s):  
Lymph Node ◽  
Liver Metastases ◽  
Bone Metastases ◽  
Lymph Node Metastases ◽  
Egfr Mutation ◽  
Poor Response ◽  
The Poor ◽  
Node Metastases ◽  
Tki Treatment ◽  
Nsclc Patients

e21527 Background: The retrospective study was performed to evaluate the clinicopathological characteristics and survival associated with distant metastasis from advanced NSCLC with EGFR mutation. Methods: The records of metastasis NSCLC patients with EGFR mutation at the time of diagnosis between 2012 and 2018 were reviewed. The Kaplan-Meier method was used to assess survival curves and the log-rank test was used in the univariate analysis. The multivariate survival analysis were performed using the Cox proportional hazards model to investigate the effects of clinicopathological factors on survival. All the statistical analyses were performed using SPSS 23.0 statistical software and a statistically significant difference was determined as P < 0.05. Results: A total of 258 NSCLC patients with EGFR mutation were enrolled in this study, including 146 cases of female (56.6%), 241 cases of adenocarcinoma (93.4%) and 212 cases of non-smokers (82.2%). Among these patients, 65(25.2%), 111(43.0%), 22(8.5%), 107 (41.5%), 11(4.3%), 87 (33.7%), 65 (25.2%) had brain, bone, liver, lung, adrenal gland, pleural metastasis and extrathoracic lymph node metastases, respectively. The median OS of total patients was 32.9 months (95% CI: 29.8-36.0). In the univariate analysis, patients with metastases to the bone (p = 0.001), liver (p = 0.012), extrathoracic lymph node(p = 0.006), and pleural(p = 0.008) exhibited a poorer survival compared to those without metastases to these regions. Abdominal metastases (p = 0.005) and extremity metastases (p = 0.002) were statistically independent prognostic factors. Association between metastatic region and the response to TKI treatment, liver metastases (p = 0.033), extrathoracic lymph node metastases (p = 0.000) and bone metastases (p = 0.009) were correlated with the poor response of TKI treatment, and the abdominal metastasis ( p= 0.029) and extremity metastases ( p= 0.016) were correlated with the poor response of TKI treatment. Conclusions: Bone metastases, liver metastases, extrathoracic lymph node metastases and pleural metastases were independent prognostic factors of NSCLC patients with EGFR mutation. Liver metastases, extrathoracic lymph node metastases, and bone metastases were correlated with the poor response of TKI treatment.

scholarly journals A Case of Carcinoid Tumor of the Vater's papilla, Accompanied by Liver Metastases and Lymph Node Metastases.

2000 ◽  
Vol 33 (3) ◽  
pp. 342-346 ◽  
Author(s):  
Shigeo Hasegawa ◽  
Akira Suzuki ◽  
Yousuke Sakai ◽  
Satoshi Ootsuka ◽  
Kumiko Suzuki ◽  
...  
Keyword(s):  
Lymph Node ◽  
Liver Metastases ◽  
Carcinoid Tumor ◽  
Lymph Node Metastases ◽  
Node Metastases ◽  
Vater’S Papilla ◽  
Vater's Papilla

Comparison of 11C-choline-PET/CT and whole body-MRI for staging of prostate cancer

2007 ◽  
Vol 46 (05) ◽  
pp. 161-168 ◽  
Author(s):  
A. C. Pfannenberg ◽  
A. Rieger ◽  
P. Aschoff ◽  
M. Müller ◽  
F. Paulsen ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Lymph Node ◽  
Bone Metastases ◽  
Lymph Node Metastases ◽  
Specific Antigen ◽  
Whole Body ◽  
Curative Therapy ◽  
Pet Ct ◽  
Node Metastases ◽  
Consensus Reading

SummaryAim of this study was to compare the diagnostic accuracy of positron emission tomography and computed tomography with 11C-Choline (Cho-PET/CT) and whole body magnetic resonance imaging (WB-MRI) for diagnostic work-up of prostate cancer. Patients, methods: We evaluated retrospectively 42 patients with untreated prostate cancer (n = 17), or increasing levels of prostate-specific antigen (PSA) after curative therapy (n = 25) who had been investigated by both Cho-PET/CT and WB-MRI. MRI, CT, and PET images were separately analyzed by experienced radiologists or nuclear medicine experts, followed by consensus reading. Validation was established by histology, follow-up, or consensus reading. Results: 88/103 detected lesions were considered as malignant: 44 bone metastases, 22 local tumor, 15 lymph node metastases, 3 lung, and 3 brain metastases. One further lesion was located in the adrenal gland, which was a second tumor. Overall sensitivity, specificity and accuracy for Cho-PET/CT were 96.6%, 76.5%, and 93.3%, resp., and for WB-MRI 78.4%, 94.1%, and 81.0%, resp. 3 vertebral metastases had initially been missed by Cho-PET/CT and were found retrospectively. MRI identified 2 bone metastases and 1 lymph node metastasis after being informed about the results of Cho-PET/CT. Conclusions: Cho-PET/CT and WB-MRI both presented high accuracy in the detection of bone and lymph node metastases. The strength of MRI is excellent image quality providing detailed anatomical information whereas the advantage of Cho-PET/CT is high image contrast of pathological foci.

Safety and efficacy of reduced dose and margins to involved lymph node metastases in locally advanced NSCLC patients

2020 ◽  
Vol 143 ◽  
pp. 66-72 ◽  
Author(s):  
Judi N.A. van Diessen ◽  
Margriet Kwint ◽  
Jan-Jakob Sonke ◽  
Iris Walraven ◽  
Barbara Stam ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastases ◽  
Advanced Nsclc ◽  
Locally Advanced ◽  
Safety And Efficacy ◽  
Reduced Dose ◽  
Locally Advanced Nsclc ◽  
Node Metastases ◽  
Nsclc Patients

The expression of CYP2W1 in colorectal primary tumors, corresponding lymph node metastases and liver metastases

2014 ◽  
Vol 53 (7) ◽  
pp. 885-891 ◽  
Author(s):  
Kristina Stenstedt ◽  
Marja Hallstrom ◽  
Frida Lédel ◽  
Peter Ragnhammar ◽  
Magnus Ingelman-Sundberg ◽  
...  
Keyword(s):  
Lymph Node ◽  
Liver Metastases ◽  
Lymph Node Metastases ◽  
Primary Tumors ◽  
Node Metastases

scholarly journals Tumor volume is more reliable to predict nodal metastasis in non-small cell lung cancer of 3 cm or less in diameter

2020 ◽  
Author(s):  
Bei Jia ◽  
Biao Chen ◽  
Hao Long ◽  
Tiehua Rong ◽  
Xiaodong Su
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastases ◽  
Pearson Correlation ◽  
Lymph Node Involvement ◽  
Nodal Metastasis ◽  
Positive Lymph Node ◽  
Node Metastases ◽  
Involvement Rate ◽  
Nsclc Patients ◽  
The Relationship

Abstract Background In this study, we sought to evaluate the correlation between TV, GTD, and lymph node metastases in NSCLC patients with tumors ≤ 3.0 cm. Methods We retrospectively analyzed the relationship between the clinicopathologic variables and lymph node involvement in 285 NSCLC patients with tumors ≤ 3.0 cm who accepted curative surgical resection. The TVs were semi-automatically measured by a software and optimal cutoff points obtained using X-tile software. The relationship between GTD and TV were described using non-linear regression. The correlation between GTD, TV, and N stages were analyzed using the Pearson correlation coefficient. The One-Way ANOVA was used to compare the GTD and TV of different lymph node stage groups. Results The relationship between GTD and TV accorded with the exponential growth model:y = 0.113e1.455x (y = TV, x = GTD). TV for patients with node metastases (4.782.83 cm3) was significantly greater for those without metastases (3.572.62 cm3) (P<0.001). However, there were no obvious GTD differences in cases with or without lymph node metastases (P = 0.054). We divided all cases into three TV groups using the two cutoff values (0.9 cm3 and 3.9 cm3) and there was an obvious difference in the lymphatic involvement rate between the groups (P<0.001). The tendency to metastasize was greater with higher TV especially when the TV was >0.9–14.2 cm3 (P = 0.010). Conclusions For NSCLC tumors ≤ 3.0 cm, TV is a more sensitive marker than GTD in predicting the positive lymph node metastases. The likelihood for metastasis increases with an increasing TV especially when GTD is > 2.0–3.0 cm.

scholarly journals EpCAM expression in lymph node and bone metastases of prostate carcinoma: A pilot study.

2014 ◽  
Vol 32 (4_suppl) ◽  
pp. 165-165
Author(s):  
Hilde Hoving ◽  
Karen Campos ◽  
Igle De Jong
Keyword(s):  
Lymph Node ◽  
Lymph Nodes ◽  
Bone Metastases ◽  
Sensitivity And Specificity ◽  
Prostate Carcinoma ◽  
Lymph Node Metastases ◽  
Hormonal Treatment ◽  
Clinicopathological Parameters ◽  
Epcam Expression ◽  
Node Metastases

165 Background: Correct staging of prostate carcinoma has huge treatment implications since metastasized prostate carcinoma cannot be treated curatively. Nowadays, skeletal scintigraphy is the mainstay for the assessment for bone metastases despite its poor sensitivity. Lymph node metastases can be diagnosed accurately with Computed Tomography. However, the gold standard is a pelvic lymph node dissection. A non-invasive diagnostic modality, that can assess both lymph node and bone metastases simultaneously, is preferred. In this retrospective pilot study expression of epithelial cell adhesion molecule (EpCAM) was investigated in lymph node metastases, normal lymph nodes, and bone metastases of prostate carcinoma. Furthermore, EpCAM expression was correlated to clinicopathological parameters. Methods: Lymph node metastases (n = 22) and matched normal lymph nodes (n = 22) were available in 17 patients who underwent a pelvic lymph node dissection because of suspicion of nodal involvement on CT. Bone metastases (n = 24) were available in 24 patients who underwent surgery to confirm the disease or to treat skeletal related events. Immunohistochemistry was performed to determine EpCAM expression. Two researchers, blinded to clinical data, scored the immunoreactivity according to Allred. Sensitivity and specificity of EpCAM immunoreactivity in lymph node and bone metastases was calculated. Fisher’s Exact Test was used to correlate EpCAM expression to the clinicopathological parameters Gleason score, prior radiotherapy and prior hormonal treatment. Results: Sensitivity and specificity of EpCAM expression was 100% in lymph nodes. In bone metastases sensitivity was 92%. No correlation between EpCAM expression and clinicopathological parameters was found. Conclusions: Molecular imaging of EpCAM is promising for prostate carcinoma staging, due to the high sensitivity and specificity in lymph node metastases and the high sensitivity in bone metastases. Even in poorly differentiated metastases and after hormonal treatment and radiotherapy, EpCAM was expressed.

scholarly journals Long-Term Recurrence-Free Survival After Metachronous Surgery of the Stomach and Liver for Gastric Adenocarcinoma and Multiple, Synchronous Liver Metastases: A Case Report and Review of Literature

2013 ◽  
Vol 98 (3) ◽  
pp. 241-246 ◽  
Author(s):  
Yoshito Kiyasu
Keyword(s):  
Lymph Node ◽  
Liver Metastases ◽  
Gastric Adenocarcinoma ◽  
Lymph Node Metastases ◽  
Regional Lymph Node ◽  
Term Survival ◽  
Severe Diarrhea ◽  
Regional Lymph Node Dissection ◽  
Node Metastases

Abstract This report describes a 58-year-old woman with gastric adenocarcinoma and liver metastases, who survives for more than 18 years after diagnosis. At diagnosis and first surgery, a moderately differentiated gastric adenocarcinoma with subserosal invasion was detected, along with 2 regional lymph node metastases and 2 liver metastases. She underwent gastrectomy and regional lymph node dissection but did not undergo liver operation then. After gastrectomy, she received adjuvant chemotherapy for 1 month but discontinued it due to severe diarrhea. Another metastasis in another area of the liver was detected, for which she underwent excision of the right lobe of the liver (subsegments 5, 6, and 7) about 30 months later. No signs of recurrence have been detected for 18 years (as of March 2012). This patient represents a rare case of long-term survival of gastric adenocarcinoma without recurrence after surgical treatment, despite multiple, synchronous, liver and regional lymph node metastases.

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