Endoscopic screening for upper gastrointestinal malignancy

2019 ◽  
pp. 53-66
Author(s):  
H. Barr
Keyword(s):  
Endoscopic Screening ◽  
Gastrointestinal Malignancy ◽  
Upper Gastrointestinal

scholarly journals Risk Prediction of Barrett’s Esophagus in a Taiwanese Health Examination Center Based on Regression Models

2021 ◽  
Vol 18 (10) ◽  
pp. 5332
Author(s):  
Po-Hsiang Lin ◽  
Jer-Guang Hsieh ◽  
Hsien-Chung Yu ◽  
Jyh-Horng Jeng ◽  
Chiao-Lin Hsu ◽  
...  
Keyword(s):  
Barrett’S Esophagus ◽  
Risk Prediction ◽  
Barrett's Esophagus ◽  
Gastrointestinal Endoscopy ◽  
Prediction Models ◽  
Upper Gastrointestinal Endoscopy ◽  
Health Examination ◽  
Endoscopic Screening ◽  
Risk Prediction Models ◽  
Upper Gastrointestinal

Determining the target population for the screening of Barrett’s esophagus (BE), a precancerous condition of esophageal adenocarcinoma, remains a challenge in Asia. The aim of our study was to develop risk prediction models for BE using logistic regression (LR) and artificial neural network (ANN) methods. Their predictive performances were compared. We retrospectively analyzed 9646 adults aged ≥20 years undergoing upper gastrointestinal endoscopy at a health examinations center in Taiwan. Evaluated by using 10-fold cross-validation, both models exhibited good discriminative power, with comparable area under curve (AUC) for the LR and ANN models (Both AUC were 0.702). Our risk prediction models for BE were developed from individuals with or without clinical indications of upper gastrointestinal endoscopy. The models have the potential to serve as a practical tool for identifying high-risk individuals of BE among the general population for endoscopic screening.

Increased platelet aggregation and production of platelet-derived microparticles after surgery for upper gastrointestinal malignancy

2003 ◽  
Vol 115 (2) ◽  
pp. 174-183 ◽  
Author(s):  
Masataka Ikeda ◽  
Shin-ichi Iwamoto ◽  
Hiroshi Imamura ◽  
Hiroshi Furukawa ◽  
Tomio Kawasaki
Keyword(s):  
Platelet Aggregation ◽  
Gastrointestinal Malignancy ◽  
Upper Gastrointestinal

An unusual presentation of synchronous bladder metastases from an oesophageal adenocarcinoma

2021 ◽  
Vol 103 (7) ◽  
pp. e227-e230
Author(s):  
D Wignall ◽  
R Sawant ◽  
A Gkentzis ◽  
L Lee
Keyword(s):  
Multidisciplinary Approach ◽  
Clinical Evidence ◽  
Oesophageal Carcinoma ◽  
Oesophageal Adenocarcinoma ◽  
Gastrointestinal Malignancy ◽  
Direct Invasion ◽  
Bladder Abnormalities ◽  
Upper Gastrointestinal ◽  
Progressive Dysphagia

Adenocarcinoma of the bladder is a rare form of malignancy accounting for fewer than 2% of bladder tumours. It is most commonly a result of direct invasion from prostatic, rectal or gynaecological primaries and less commonly presents from distant haematological or lymphatic metastasis. We report a rare case of oesophageal carcinoma metastasising to the bladder. It involves a 71-year-old man with progressive dysphagia and diagnostic computerised tomography findings of thickening in the oesophagus, bladder and common bile duct. Subsequent endoscopic biopsies of the oesophageal and bladder abnormalities showed immunohistochemical features consistent with upper gastrointestinal malignancy. This report aims to add to current clinical evidence of this route of metastasis and also highlight some of the key markers used by pathologists in interpretation of specimens. It also emphasises the essential role of a multidisciplinary approach for the diagnosis of such rare conditions.

scholarly journals Effectiveness of one-time endoscopic screening programme in prevention of upper gastrointestinal cancer in China: a multicentre population-based cohort study

Gut ◽  
2020 ◽  
pp. gutjnl-2019-320200 ◽  
Author(s):  
Ru Chen ◽  
Yong Liu ◽  
Guohui Song ◽  
Bianyun Li ◽  
Deli Zhao ◽  
...  
Keyword(s):  
Cohort Study ◽  
Cancer Incidence ◽  
Gastrointestinal Cancer ◽  
Screening Programme ◽  
Population Based ◽  
Control Group ◽  
Endoscopic Screening ◽  
Upper Gastrointestinal Cancer ◽  
Incidence And Mortality ◽  
Upper Gastrointestinal

ObjectivesTo estimate the effectiveness of endoscopic screening programme in reducing incidence and mortality of upper gastrointestinal cancer in high risks areas of China.DesignThis multicentre population-based cohort study was conducted in six areas in China from 2005 to 2015. All permanent residents aged 40 to 69 years were identified as target subjects. We refer to those who were invited for screening collectively as the invited group. Of these, we classify those who were invited and undertook endoscopic screening as the screened group and those who were invited but did not accept screening as the non-screened group. Target subjects who were not invited to the screening were assigned to the control group. The effectiveness of the endoscopic screening and screening programme were evaluated by comparing reductions in incidence and mortality from upper gastrointestinal cancer in the screened and invited group with control group.ResultsOur cohort analysis included 637 500 people: 299 483 in the control group and 338 017 in the invited to screening group, 113 340 (33.53%) of whom were screened eventually. Compared with subjects in the control group, upper gastrointestinal cancer incidence and mortality decreased by 23% (relative risk (RR)=0.77, 95% CI 0.74 to 0.81) and 57% (RR=0.43, 95% CI 0.40 to 0.47) in the screened group, respectively, and by 14% (RR=0.86, 95% CI 0.84 to 0.89) and 31% (RR=0.69, 95% CI 0.66 to 0.72) in the invited group, respectively.ConclusionAmong individuals aged 40 to 69 years in high risk areas of upper gastrointestinal cancer, one-time endoscopic screening programme was associated with a significant decrease in upper gastrointestinal cancer incidence and mortality.

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