Paving a New Era in Patient Centric Care through Innovations in Precision Medicine

2019 ◽  
pp. 190-198
Author(s):  
Mark D. Fidock ◽  
Glen Hughes ◽  
Alain J. van Gool ◽  
Claudio Carini
Keyword(s):  
Precision Medicine ◽  
New Era ◽  
Patient Centric

scholarly journals Recent Advances in Single-Cell Profiling and Multispecific Therapeutics: Paving the Way for a New Era of Precision Medicine Targeting Cardiac Fibroblasts

2021 ◽  
Vol 23 (7) ◽  
Author(s):  
Sally Yu Shi ◽  
Xin Luo ◽  
Tracy M. Yamawaki ◽  
Chi-Ming Li ◽  
Brandon Ason ◽  
...  
Keyword(s):  
Heart Failure ◽  
Precision Medicine ◽  
Single Cell ◽  
Cardiac Fibroblasts ◽  
Rapid Development ◽  
Cardiac Fibroblast ◽  
New Era ◽  
Fibroblast Activation ◽  
Cell Gene Expression ◽  
The Way

Abstract Purpose of Review Cardiac fibroblast activation contributes to fibrosis, maladaptive remodeling and heart failure progression. This review summarizes the latest findings on cardiac fibroblast activation dynamics derived from single-cell transcriptomic analyses and discusses how this information may aid the development of new multispecific medicines. Recent Findings Advances in single-cell gene expression technologies have led to the discovery of distinct fibroblast subsets, some of which are more prevalent in diseased tissue and exhibit temporal changes in response to injury. In parallel to the rapid development of single-cell platforms, the advent of multispecific therapeutics is beginning to transform the biopharmaceutical landscape, paving the way for the selective targeting of diseased fibroblast subpopulations. Summary Insights gained from single-cell technologies reveal critical cardiac fibroblast subsets that play a pathogenic role in the progression of heart failure. Combined with the development of multispecific therapeutic agents that have enabled access to previously “undruggable” targets, we are entering a new era of precision medicine.

scholarly journals Precision Medicine: A New Era

2018 ◽  
Vol 22 (6) ◽  
pp. 637-639
Author(s):  
Lisa M. Giles ◽  
David L. Cooper
Keyword(s):  
Precision Medicine ◽  
New Era

scholarly journals Transforming clinical trials in rheumatology: towards patient-centric precision medicine

2020 ◽  
Vol 16 (10) ◽  
pp. 590-599 ◽  
Author(s):  
Costantino Pitzalis ◽  
Ernest H. S. Choy ◽  
Maya H. Buch
Keyword(s):  
Clinical Trials ◽  
Precision Medicine ◽  
Patient Centric

scholarly journals AB0499 FINGERSTICK BLOOD TRANSCRIPTOMICS: A PATIENT-CENTRIC APPROACH TO ENABLE PRECISION MEDICINE?

2019 ◽  
Author(s):  
Matteo Cesaroni ◽  
Jessica Schreiter ◽  
Loqmane Seridi ◽  
Jarrat Jordan ◽  
Marc Chevrier ◽  
...  
Keyword(s):  
Precision Medicine ◽  
Patient Centric ◽  
Blood Transcriptomics

scholarly journals A New Era of Prostate Cancer Precision Medicine

2019 ◽  
Vol 9 ◽  
Author(s):  
Adil Malik ◽  
Srilakshmi Srinivasan ◽  
Jyotsna Batra
Keyword(s):  
Prostate Cancer ◽  
Precision Medicine ◽  
New Era

scholarly journals The Challenges of Data Visualization for Precision Medicine

2019 ◽  
Vol 8 (1) ◽  
pp. 120-124
Author(s):  
Tatiana Silva Bevilacqua ◽  
Raphael Mendoza da Nobrega ◽  
Helen Chen ◽  
Plinio Pelegrini Morita
Keyword(s):  
Machine Learning ◽  
Deep Learning ◽  
Precision Medicine ◽  
Data Visualization ◽  
Essential Role ◽  
Decision Makers ◽  
New Era ◽  
Current Trends ◽  
Treatment Data ◽  
Visualization Of Data

Precision medicine is driving medicine towards a new era where technology and large amounts of data come together to play an essential role in treatment. Data needed to empower and inform decision-makers can be overwhelming to interpret and poses unique challenges related to the visualization of data generated by machine learning and deep learning algorithms. Therefore, the present study aims to provide an in-depth understanding of the challenges, current trends, and opportunities concerning data visualization for precision medicine.

scholarly journals Precision Neurosurgery: A Path Forward

2021 ◽  
Vol 11 (10) ◽  
pp. 1019
Author(s):  
Vianney Gilard ◽  
Stéphane Derrey ◽  
Stéphane Marret ◽  
Soumeya Bekri ◽  
Abdellah Tebani
Keyword(s):  
Precision Medicine ◽  
Data Analytics ◽  
Historical Perspective ◽  
Molecular Profiling ◽  
Data Driven ◽  
Medical Community ◽  
Technological Advances ◽  
Conceptual Shift ◽  
The Impact ◽  
Patient Centric

Since the inception of their profession, neurosurgeons have defined themselves as physicians with a surgical practice. Throughout time, neurosurgery has always taken advantage of technological advances to provide better and safer care for patients. In the ongoing precision medicine surge that drives patient-centric healthcare, neurosurgery strives to effectively embrace the era of data-driven medicine. Neuro-oncology best illustrates this convergence between surgery and precision medicine with the advent of molecular profiling, imaging and data analytics. This convenient convergence paves the way for new preventive, diagnostic, prognostic and targeted therapeutic perspectives. The prominent advances in healthcare and big data forcefully challenge the medical community to deeply rethink current and future medical practice. This work provides a historical perspective on neurosurgery. It also discusses the impact of the conceptual shift of precision medicine on neurosurgery through the lens of neuro-oncology.

scholarly journals Results of the Seventh Scientific Workshop of ECCO: Precision medicine in IBD - disease outcome and response to therapy

2021 ◽  
Author(s):  
Bram Verstockt ◽  
Nurulamin M Noor ◽  
Urko M Marigorta ◽  
Polychronis Pavlidis ◽  
Parakkal Deepak ◽  
...  
Keyword(s):  
Precision Medicine ◽  
Response To Therapy ◽  
Treatment Algorithms ◽  
New Era ◽  
Extreme Phenotypes ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
Omic Data Integration ◽  
Omic Data ◽  
Prognostic And Predictive Markers

Abstract Inflammatory bowel diseases [IBD] are a heterogeneous spectrum with two extreme phenotypes, Crohn’s disease [CD] and ulcerative colitis [UC], which both represent numerous phenotypical variations. Hence, we should no longer approach all IBD patients similarly, but rather aim to rethink clinical classifications and modify treatment algorithms to usher in a new era of precision medicine in IBD. This scientific ECCO workshop aims to provide a state-of-the-art overview on prognostic and predictive markers, shed light on key questions in biomarker development, propose best practices in IBD biomarker development [including trial design], and discuss the potential for multi-omic data integration to help drive further advances to make precision medicine a reality in IBD.

scholarly journals From single gene analysis to single cell profiling: a new era for precision medicine

2020 ◽  
Vol 39 (1) ◽  
Author(s):  
Maria Teresa Di Martino ◽  
Stefania Meschini ◽  
Katia Scotlandi ◽  
Chiara Riganti ◽  
Enrico De Smaele ◽  
...  
Keyword(s):  
Precision Medicine ◽  
Single Cell ◽  
Single Gene ◽  
Gene Analysis ◽  
New Era ◽  
Single Cell Profiling
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