Radiosurgery for Ocular Disorders

2021 ◽  
pp. 277-286
Author(s):  
Roman Lišcˇák ◽  
Gabriela Šimonová
Keyword(s):  
Ocular Disorders

scholarly journals Advantages and Disadvantages of Using Magnetic Nanoparticles for the Treatment of Complicated Ocular Disorders

Pharmaceutics ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1157
Author(s):  
Elena K. Schneider-Futschik ◽  
Felisa Reyes-Ortega
Keyword(s):  
Magnetic Field ◽  
Magnetic Nanoparticles ◽  
Therapeutic Efficacy ◽  
Genetic Diseases ◽  
Systemic Exposure ◽  
Drug Carriers ◽  
Three Dimensions ◽  
Target Point ◽  
Advantages And Disadvantages ◽  
Ocular Disorders

Nanomaterials provide enormous opportunities to overcome the limitations of conventional ocular delivery systems, such as low therapeutic efficacy, side effects due to the systemic exposure, or invasive surgery. Apart from the more common ocular disorders, there are some genetic diseases, such as cystic fibrosis, that develop ocular disorders as secondary effects as long as the disease progresses. These patients are more difficult to be pharmacologically treated using conventional drug routes (topically, systemic), since specific pharmacological formulations can be incompatible, display increased toxicity, or their therapeutic efficacy decreases with the administration of different kind of chemical molecules. Magnetic nanoparticles can be used as potent drug carriers and magnetic hyperthermia agents due to their response to an external magnetic field. Drugs can be concentrated in the target point, limiting the damage to other tissues. The other advantage of these magnetic nanoparticles is that they can act as magnetic resonance imaging agents, allowing the detection of the exact location of the disease. However, there are some drawbacks related to their use in drug delivery, such as the limitation to maintain efficacy in the target organ once the magnetic field is removed from outside. Another disadvantage is the difficulty in maintaining the therapeutic action in three dimensions inside the human body. This review summarizes all the application possibilities related to magnetic nanoparticles in ocular diseases.

scholarly journals Review for Disease of the Year: Epidemiology of HLA-B27 Associated Ocular Disorders

2016 ◽  
Vol 24 (4) ◽  
pp. 470-475 ◽  
Author(s):  
Laura J. Kopplin ◽  
George Mount ◽  
Eric B. Suhler
Keyword(s):  
Hla B27 ◽  
Ocular Disorders

scholarly journals Zebrafish Dscaml1 is Essential for Retinal Patterning and Function of Oculomotor Subcircuits

2019 ◽  
Author(s):  
Manxiu Ma ◽  
Alexandro D. Ramirez ◽  
Tong Wang ◽  
Rachel L. Roberts ◽  
Katherine E. Harmon ◽  
...  
Keyword(s):  
Animal Model ◽  
Light Adaptation ◽  
Neural Circuit ◽  
Oculomotor System ◽  
Gaze Stabilization ◽  
Ocular Disorders ◽  
Motor Apraxia ◽  
Premotor Pathways ◽  
And Function ◽  
Circuit Function

AbstractDown Syndrome Cell Adhesion Molecules (dscam and dscaml1) are essential regulators of neural circuit assembly, but their roles in vertebrate neural circuit function are still mostly unexplored. We investigated the role of dscaml1 in the zebrafish oculomotor system, where behavior, circuit function, and neuronal activity can be precisely quantified. Loss of zebrafish dscaml1 resulted in deficits in retinal patterning and light adaptation, consistent with its known roles in mammals. Oculomotor analyses showed that mutants have abnormal gaze stabilization, impaired fixation, disconjugation, and faster fatigue. Notably, the saccade and fatigue phenotypes in dscaml1 mutants are reminiscent of human ocular motor apraxia, for which no animal model exists. Two-photon calcium imaging showed that loss of dscaml1 leads to impairment in the saccadic premotor pathway but not the pretectum-vestibular premotor pathway, indicating a subcircuit requirement for dscaml1. Together, we show that dscaml1 has both broad and specific roles in oculomotor circuit function, providing a new animal model to investigate the development of premotor pathways and their associated human ocular disorders.

scholarly journals A Spectrum of Ophthalmic Diseases in a Tertiary Care Hospital in Peshawar, KPK; a 10-Year Retrospective Study

2019 ◽  
Vol 35 (1) ◽  
Author(s):  
Muhammad Rafiq Afridi Khalid Saifullah Baig Omer Nasim, Salman Khan
Keyword(s):  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Data Bank ◽  
Cross Sectional Study ◽  
Medical Institute ◽  
Care Hospital ◽  
Sectional Study ◽  
Cross Sectional ◽  
Ocular Disorders ◽  
Systemic Condition

Correspondence to: Omer Nasim Ophthalmology Unit Rehman Medical Institute (RMI), Peshawar Email: [email protected] Purpose: To assess the frequency of different eye morbidities in the patients presenting at a tertiary care Hospital in Peshawar. Study Design: Cross sectional study. Place and Duration of Study: Ophthalmology unit of Rehman Medical Institute (RMI), Peshawar from February 2004 to month of March 2014. Material & Methods: This research involved accessing the data bank kept by the Hospital. All ocular morbidities seen during the study period was included in the study while those who presented with the diseases of the eye due to some other systemic condition were excluded. Patients were categorized according to their gender and year of admission. The age categories were divided into 5 groups, 0-20, 21-40, 41-60, 61-80, 81-100 years’ category. The data collected was analyzed using MS Excel 2013. Results: A total of 1869 patients were examined out of which 49.92% were male and 50.07% were female. The ocular examination revealed that out of the 1869 patients, 57.30% of the patients suffered from Cataract, 4.86% patients suffered from Pterygium, 4.76% suffered from Strabismus, 1.65% patients suffered from Glaucoma and the remaining 31.43% suffered from various spectrum of diseases. Female preponderance was more than males in the sense of general morbidity of ocular disorders.

scholarly journals Neurosyphilis Presenting as Asymptomatic Optic Perineuritis

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Sarah E. Parker ◽  
John H. Pula
Keyword(s):  
White Cell Count ◽  
Brain Mri ◽  
Transmitted Disease ◽  
The United States ◽  
Opening Pressure ◽  
Disc Edema ◽  
Sexually Transmitted ◽  
Nerve Sheath ◽  
Clinical Presentations ◽  
Ocular Disorders

Introduction. Syphilis is a sexually transmitted disease that is known as “the great imitator” due to its wide variety of clinical presentations, including ocular disorders. There has been an increase in the rate of syphilis in the United States, especially in persons with HIV. We report a case of optic perineuritis in an asymptomatic male secondary to central nervous system (CNS) syphilis.Case Report. A 41-year-old man was found to have bilateral disc edema on a routine exam. Brain MRI was unremarkable, and lumbar puncture revealed a normal opening pressure, with an elevated cerebrospinal fluid white cell count. Orbit MRI showed optic nerve sheath expansion and enhancement, consistent with optic perineuritis. He tested positive for syphilis based on serum RPR and FTA-ABS.Conclusion. Ophthalmologic findings, including disc edema, may be the presenting features of CNS syphilis. Even in asymptomatic persons, perineuritis should be considered early, as diagnosis and treatment are imperative given the progressive nature of the disease.

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