Risk prevention measures were put forward about vehicle burning in operating periods for three-tower and four-span suspension bridge, combining with the characteristics of bridge vehicle burning accident. The article set up a traffic reporting system of the tankers for a bridge, and determined the report system of tankers across the bridge. Tankers should passed in the middle of the lane near the median under the guidance of bridge manager. Significant indicators were set on both ends of the bridge, so that vehicles could shunt rapidly in extreme fire conditions. Department of public security, fire control, transportation, bridges management center should get together to establish accident emergency rescue leading group, and formulated the security system of fire resistance and rescue organization for YingWuzhou Yangtze river bridge. Video monitoring alarm system and fire control facilities were set up in side pier, side tower, middle of the main span and the middle tower, which provided reliable and prevention measures for bridge operation.