Common Diseases Found in Inbred Strains of Laboratory Mice

SummaryMice are the most widely used experimental mammals, and many inbred strains are available. However, except for the relatively recent strains derived from known wild populations, the relationships between wild and laboratory mice are not well understood. Based on the Y-chromosomal restriction fragmentlength polymorphism, seventeen inbred strains were classified into two groups: strains with the Mus musculus musculus type Y chromosome and those with the M. m. domesticus type Y chromosome. We extended the survey to an additional twenty-two inbred strains. The M. m. musculus type Y chromosome was found in AEJ/GnLe, AAU/SsJ, BDP/J, BXSB/MpJ, DA/HuSn, HTG/GoSfSn, I/LnJ, LP/J, NZW/LacJ, RIIIS/J, SB/Le, SEA/GnJ, SF/CamEi, SK/CamEi, SM/J, WB/ReJ, WC/ReJ and YBR/Ei, while the M. m. domesticus type Y chromosome was present in BUB/BnJ, MA/MyJ, PL/J and ST/bJ.

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Peer Review #3 of "Temporal dynamics of the developing lung transcriptome in three common inbred strains of laboratory mice reveals multiple stages of postnatal alveolar development (v0.1)"

10.7287/peerj.2318v0.1/reviews/3 ◽

2016 ◽

Author(s):

A Holik

Keyword(s):

Peer Review ◽

Temporal Dynamics ◽

Inbred Strains ◽

Laboratory Mice ◽

Alveolar Development ◽

Multiple Stages

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Temporal dynamics of the developing lung transcriptome in three common inbred strains of laboratory mice reveals multiple stages of postnatal alveolar development

PeerJ ◽

10.7717/peerj.2318 ◽

2016 ◽

Vol 4 ◽

pp. e2318 ◽

Cited By ~ 29

Author(s):

Kyle J. Beauchemin ◽

Julie M. Wells ◽

Alvin T. Kho ◽

Vivek M. Philip ◽

Daniela Kamir ◽

...

Keyword(s):

Gene Expression ◽

Lung Development ◽

Transcriptional Activity ◽

Expression Patterns ◽

Inbred Strains ◽

Expression Data ◽

Laboratory Mice ◽

Alveolar Development ◽

Matrix Organization ◽

Strain Dependent

To characterize temporal patterns of transcriptional activity during normal lung development, we generated genome wide gene expression data for 26 pre- and post-natal time points in three common inbred strains of laboratory mice (C57BL/6J, A/J, and C3H/HeJ). Using Principal Component Analysis and least squares regression modeling, we identified both strain-independent and strain-dependent patterns of gene expression. The 4,683 genes contributing to the strain-independent expression patterns were used to define a murine Developing Lung Characteristic Subtranscriptome (mDLCS). Regression modeling of the Principal Components supported the four canonical stages of mammalian embryonic lung development (embryonic, pseudoglandular, canalicular, saccular) defined previously by morphology and histology. For postnatal alveolar development, the regression model was consistent with four stages of alveolarization characterized by episodic transcriptional activity of genes related to pulmonary vascularization. Genes expressed in a strain-dependent manner were enriched for annotations related to neurogenesis, extracellular matrix organization, and Wnt signaling. Finally, a comparison of mouse and human transcriptomics from pre-natal stages of lung development revealed conservation of pathways associated with cell cycle, axon guidance, immune function, and metabolism as well as organism-specific expression of genes associated with extracellular matrix organization and protein modification. The mouse lung development transcriptome data generated for this study serves as a unique reference set to identify genes and pathways essential for normal mammalian lung development and for investigations into the developmental origins of respiratory disease and cancer. The gene expression data are available from the Gene Expression Omnibus (GEO) archive (GSE74243). Temporal expression patterns of mouse genes can be investigated using a study specific web resource (http://lungdevelopment.jax.org).

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Post-stress chemosignals affect cells from immunocompetent organs in laboratory mice of three inbred strains

Ecological genetics ◽

10.17816/ecogen6127-33 ◽

2008 ◽

Vol 6 (1) ◽

pp. 27-33 ◽

Cited By ~ 1

Author(s):

Eugene V Daev ◽

Boris P Surinov ◽

Anna V Dukelskaya

Keyword(s):

Bone Marrow ◽

Bone Marrow Cells ◽

Physiological State ◽

Inbred Strains ◽

Laboratory Mice ◽

Immunocompetent Organs ◽

Dividing Cells ◽

First Time ◽

Mitotic Disturbances ◽

Post Stress

Quantity of antibody producing cells and changes in bone marrow dividing cells of mouse males were studied after the exposure with chemosignals from intact or stressed donor mouse males. Inbred CBA, BALB/c and C57BL/6 strains were used. It is shown that excreted volatiles decrease quantity of antibody producing cells in spleen and at the same time raise the level of mitotic disturbances in bone marrow cells of recipient mice. Pheromone effect depends on genotype and physiological state of the recipients. For the first time we describe here the influence of mouse female pheromone 2,5-dimethylpyrazine on analyzed features. Biological meaning of the discovered effects is discussed.

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DNA determinants of structural and regulatory variation within the murine beta-glucuronidase gene complex

Molecular and Cellular Biology ◽

10.1128/mcb.9.9.4074-4078.1989 ◽

1989 ◽

Vol 9 (9) ◽

pp. 4074-4078

Author(s):

C J Wawrzyniak ◽

P M Gallagher ◽

M A D'Amore ◽

J E Carter ◽

S D Lund ◽

...

Keyword(s):

Heat Stability ◽

Inbred Strains ◽

Regulatory Elements ◽

Gus Gene ◽

Gene Complex ◽

Mrna Sequence ◽

Laboratory Mice ◽

Structural Element ◽

Regulatory Variation ◽

Sequence Variations

The murine beta-glucuronidase (GUS) gene complex, [Gus], encompasses the GUS structural element, Gus-s, and a set of regulatory elements which serve to modulate Gus-s expression. Three common GUS haplotypes representing virtually all inbred strains of laboratory mice have been compared with respect to GUS mRNA sequence. Results of such comparisons revealed sequence variations which target the location of one of the GUS regulatory elements to sequences within Gus-s and which account for known electrophoretic and heat stability differences among GUS allozymes of the three common GUS haplotypes.

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Variation of the lumbar vertebrae of mice at two environmental temperatures

Development ◽

10.1242/dev.21.1.97 ◽

1969 ◽

Vol 21 (1) ◽

pp. 97-103

Author(s):

Kathleen M. H. Munro ◽

S. A. Barnett

Keyword(s):

House Mouse ◽

Mus Musculus ◽

Environmental Temperature ◽

Lumbar Vertebrae ◽

Inbred Strains ◽

Laboratory Mice ◽

Maternal Factors ◽

Breeding Colony ◽

Environmental Temperatures

The house mouse, Mus musculus L., usually has twenty-six presacral vertebrae: these consist of seven cervical, thirteen thoracic and six lumbar vertebrae (Weber, 1950; Deol, 1958; Berry & Searle, 1963; Berry, 1964). The twenty-sixth vertebra is, however, sometimes abnormal, especially among laboratory mice: on one or both sides it may be fused with the sacrum. There are then five typical lumbar vertebrae, instead of six. The proportion of such abnormalities in a population is influenced by genotype, diet and unidentified maternal factors (reviewed by Grüneberg, 1963). Evidence is given below that a low environmental temperature can also increase the incidence of ‘sacralization of L6’. The mice used included three highly inbred strains: A/Tb, A2G/Tb and C57BL/Tb. A permanent breeding colony of each strain was kept at each of two environmental temperatures, namely, 21 °C and −3 °C. In addition, GFF mice were studied at 21 °C only.

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