Survival Analysis: Gastric Cancer and Methadone Treatment of Heroin Addicts

2001 ◽  
pp. 216-238
Keyword(s):  
Gastric Cancer ◽  
Survival Analysis ◽  
Methadone Treatment ◽  
Heroin Addicts

Aggressive responding of male heroin addicts under methadone treatment: psychometric and neuroendocrine correlates

2001 ◽  
Vol 65 (1) ◽  
pp. 85-95 ◽  
Author(s):  
Gilberto Gerra ◽  
Amir Zaimovic ◽  
Maria Augusta Raggi ◽  
Francesca Giusti ◽  
Roberto Delsignore ◽  
...  
Keyword(s):  
Methadone Treatment ◽  
Heroin Addicts

scholarly journals Political Culture and Treatment Strategies in the Nordic Countries

1996 ◽  
Vol 13 (5-6) ◽  
pp. 240-252
Author(s):  
Jan E. Grindheim
Keyword(s):  
Cultural Theory ◽  
Nordic Country ◽  
Methadone Treatment ◽  
Group Analysis ◽  
Treatment Strategies ◽  
Nordic Countries ◽  
Individual Treatment ◽  
Heroin Addicts ◽  
Set Up ◽  
Strong Control

Taking as a point of departure Mary Douglas' grid-group analysis, elaborated on by Aaron Wildavsky in his cultural theory, the article explores the variations in the development of methadone treatment programmes in the Nordic countries from the mid-1960's to the mid-1990's. In Sweden, the first Nordic country to start an organized treatment of heroin addicts with methadone in 1966, the strategy has been characterized by many rules and strong control. In Denmark, methadone treatment was introduced in the late 1960's, and it has been characterized by few rules and weak control. In Norway, methadone treatment was banned in 1979, after some years of occasional experiments. But the spread of HIV among intravenous heroin addicts altered the attitudes and a small and highly regulated program was set up in the beginnings of the 1990's. In Finland, the attitude has been reserved, primarily due to the small population of heroin addicts. The organized treatment in the 1970's was limited, and still is, as it was set up again in 1995. In spite of the differences, however, there are two main patterns of harmonization that should be noticed. Firstly, as a result of HIV, regulated programmes have been developed in all four countries in the 1990's. Secondly, the prevailing abstinence-oriented philosophy has been questioned and supplemented by harm-reducing measures. Today, there is a stronger tendency to treat drug addicts as clients in the Nordic welfare state, entitled to individual treatment in the countries' general health and welfare systems.

scholarly journals Indications of Lymph Node Metastasis and Survival Analysis in T1N+M0 Gastric Cancer: a Population-Based Study

2020 ◽  
Author(s):  
Peng Jin ◽  
Yang Li ◽  
Shuai Ma ◽  
Wenzhe Kang ◽  
Hao Liu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Gastric Cancer ◽  
Survival Analysis ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Tumor Size ◽  
Multivariate Analyses ◽  
Invasion Depth ◽  
Node Metastasis ◽  
Definition Of

Abstract Background Since the definition of early gastric cancer (EGC) was first proposed in 1971, the treatment of gastric cancer with or without lymph node metastasis (LNM) has changed a lot. The present study aims to identify risk factors for LNM and prognosis, and to further evaluate the indications for adjuvant chemotherapy (AC) in T1N + M0 gastric cancer. Methods A total of 1291 patients with T1N + M0 gastric cancer were retrieved from the Surveillance, Epidemiology, and End Results (SEER) database. Univariate and multivariate analyses were performed to identify risk factors for LNM. The effect of LNM on overall survival (OS) and cancer-specific survival (CSS) was compared with patients grouped into T1N0-1 and T1N2-3, as the indications for AC. Results The rate of LNM was 19.52%. Multivariate analyses showed age, tumor size, invasion depth, and type of differentiation and retrieved LNs were associated with LNM (p < 0.05). Cox multivariate analyses indicated age, sex, tumor size, N stage were independent predictors of OS and CSS (p < 0.05), while race was indicator for OS (HR 0.866; 95%CI 0.750–0.999, p = 0.049), but not for CSS (HR 0.878; 95% CI 0.723–1.065, p = 0.187). In addition, survival analysis showed the proportion of patients in N+/N0 was better distributed than N0-1/N2-3b. There were statistically significant differences in OS and CSS between patients with and without chemotherapy in pT1N1M0 patients (p༜0.05). Conclusions Both tumor size and invasion depth are associated with LNM and prognosis. LNM is an important predictor of prognosis. pT1N + M0 may be appropriate candidates for AC. Currently, the treatment and prognosis of T1N0M0/T1N + M0 are completely different. An updated definition of EGC, taking into tumor size, invasion depth and LNM, may be more appropriate in an era of precision medicine.

scholarly journals Predictive Value of MiR-219-1, MiR-938, MiR-34b/c, and MiR-218 Polymorphisms for Gastric Cancer Susceptibility and Prognosis

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Yanhua Wu ◽  
Zhifang Jia ◽  
Donghui Cao ◽  
Chuan Wang ◽  
Xing Wu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Survival Analysis ◽  
Distant Metastasis ◽  
Case Control Study ◽  
Cancer Susceptibility ◽  
Case Control ◽  
Cancer Prognosis ◽  
Radical Operation ◽  
Risk Of Death ◽  
Control Study

Gastric cancer (GC) is one of the most prominent global cancer-related health threats. Genes play a key role in the precise mechanisms of gastric cancer. SNPs in mi-RNAs could affect mRNA expression and then affect the risk and prognosis of GC. Firstly, we have decided to perform a case-control study which included 897 GC patients and 992 controls to evaluate the association of miR-219-1 rs213210, miR-938 rs2505901, miR-34b/c rs4938723, and miR-218 rs11134527 polymorphisms with gastric cancer susceptibility. Secondly, among the 897 GC patients above, 755 cases underwent a radical operation, without distant metastasis and with negative surgical margins included in the survival analysis to evaluate the association of the four SNPs above with gastric cancer prognosis. The C/T or C/C genotypes of rs213210 were related to a lower GC risk (OR = 0.76, 95% CI: 0.62–0.93,P=0.009) compared to the T/T genotype. Rs11134527 in miR-218 was associated with GC survival, and the G/A and G/G genotypes of rs11134527 resulted in a decreased risk of death when compared with the A/A genotype (HR = 0.75, 95% CI: 0.61–0.95,P=0.016). This study found that miR-219-1 rs213210 polymorphism was associated with GC susceptibility and rs11134527 in miR-218 was positively correlated with GC prognosis.

Methadone Treatment of Heroin Addicts

JAMA ◽  
1972 ◽  
Vol 219 (7) ◽  
pp. 910
Author(s):  
Robert A. Maslansky
Keyword(s):  
Methadone Treatment ◽  
Heroin Addicts

scholarly journals Survival analysis in gastric cancer: a multi-center study among Iranian patients

BMC Surgery ◽  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Atefeh Talebi ◽  
Afsaneh Mohammadnejad ◽  
Abolfazl Akbari ◽  
Mohamad Amin Pourhoseingholi ◽  
Hassan Doosti ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Survival Analysis ◽  
Multi Center Study ◽  
Iranian Patients ◽  
Center Study

Clinical Efficacy of Acupuncture as an Adjunct to Methadone Treatment Services for Heroin Addicts: A Randomized Controlled Trial

2014 ◽  
Vol 42 (03) ◽  
pp. 569-586 ◽  
Author(s):  
Yuan-Yu Chan ◽  
Wan-Yu Lo ◽  
Tsai-Chung Li ◽  
Lih-Jong Shen ◽  
Szu-Nian Yang ◽  
...  
Keyword(s):  
Methadone Maintenance ◽  
Short Form ◽  
Controlled Trial ◽  
Scientific Evidence ◽  
Methadone Treatment ◽  
Sham Acupuncture ◽  
Opiate Dependence ◽  
Heroin Addiction ◽  
Daily Consumption ◽  
Heroin Addicts

Scant scientific evidence supports the efficacy of acupuncture in the treatment of opiate dependence. The purpose of this study was to examine the effectiveness of acupuncture for heroin addicts on methadone maintenance by measuring the daily consumption of methadone, variations in the 36-item Short Form Health Survey-36 (SF-36) and Pittsburgh Sleep Quality Index (PSQI) scores, and heroin craving. Sixty heroin addicts were randomly assigned to true acupuncture (electroacupuncture at the Hegu [LI4] and Zusanli [ST36] acupoints, as well as acupuncture at the Ear Shenmen) or sham acupuncture (minimal acupuncture at the Hegu and Zusanli acupoints without electrical stimulation and superficial acupuncture at the Ear Shenmen), twice weekly for 4 weeks. From week 2 onwards, the daily dose of methadone was reduced by a significantly greater amount with true acupuncture compared with sham acupuncture. True acupuncture was also associated with a greater improvement in sleep latency at follow-up. All adverse events were mild in severity. Acupuncture appears to be a useful adjunct to methadone maintenance therapy (MMT) in heroin addiction.

Sign in / Sign up

Export Citation Format

Share Document