Image Informatics for Clinical and Preclinical Biomedical Analysis

Near-infrared (NIR) spectroscopy technique offers many potential advantages as tool for biomedical analysis since it enables the subtle biochemical signatures related to pathology to be detected and extracted. In conjunction with advanced chemometrics, NIR spectroscopy opens the possibility of their use in cancer diagnosis. The study focuses on the application of near-infrared (NIR) spectroscopy and classification models for discriminating colorectal cancer. A total of 107 surgical specimens and a corresponding NIR diffuse reflection spectral dataset were prepared. Three preprocessing methods were attempted and least-squares support vector machine (LS-SVM) was used to build a classification model. The hybrid preprocessing of first derivative and principal component analysis (PCA) resulted in the best LS-SVM model with the sensitivity and specificity of 0.96 and 0.96 for the training and 0.94 and 0.96 for test sets, respectively. The similarity performance on both subsets indicated that overfitting did not occur, assuring the robustness and reliability of the developed LS-SVM model. The area of receiver operating characteristic (ROC) curve was 0.99, demonstrating once again the high prediction power of the model. The result confirms the applicability of the combination of NIR spectroscopy, LS-SVM, PCA, and first derivative preprocessing for cancer diagnosis.

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Special issue on biomedical image informatics

Biomedical Engineering Letters ◽

10.1007/s13534-014-0168-5 ◽

2014 ◽

Vol 4 (4) ◽

pp. 317-318

Author(s):

Joon-Kyung Seong ◽

Myoung-Hee Kim

Keyword(s):

Special Issue ◽

Biomedical Image ◽

Image Informatics

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Recent developments in potentiometric biosensors for biomedical analysis

Analytica Chimica Acta ◽

10.1016/j.aca.2007.08.003 ◽

2007 ◽

Vol 599 (1) ◽

pp. 7-15 ◽

Cited By ~ 74

Author(s):

Robert Koncki

Keyword(s):

Biomedical Analysis ◽

Recent Developments

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Extase scopique, sédimentation langagičre et inscription corporelle. Les images dans la civilisation contemporaine

PARADIGMI ◽

10.3280/para2009-003006 ◽

2009 ◽

pp. 71-83

Author(s):

Jean-Jacques Wunenburger

Keyword(s):

Key Words ◽

The Body ◽

Pathological Conditions ◽

Image Informatics

- Linguistic Sedimentation, and Bodily Inscription At present, we are exposed to an excessive offer of images, which raises a problem of assimilation. Subjects are increasingly passive, in ways that can border on pathological conditions. Yet, it is not so much a question of condemning this situation as of finding a way of re-symbolizing images, saving them from mere contemplation and inserting them in a process of contextualisation. Such a process requires an understanding of the role of the body and of the incorporation of images along the lines of Bachelard's intuition of the "resisting" nature of images. This raises the possibility of an education to images suited to the present age.Key words: Alienation, Education, Embodiment, Image, Informatics, Symbolisation.Parole chiave: Alienazione, Educazione, Immagine, Incorporazione, Informatica, Simbolizzazione.

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