The objective of this chapter is to analyze articles on the adaptation of the elderly to NIV. The methodology is integrative literature review, using the PICO methodology. After analyzing the content covered, the authors found that there are common factors regarding the adaptation of elderly users to NIV. COPD users are the main users of NIV. This technique promotes an improvement in the quality of life. The introduction of NIV in the user's daily life requires behavioral and lifestyle changes involving health professionals, the user, and caregivers. The choice of the type of ventilator and interfaces is important, in issues such as late assessment of the user's condition and the influence of external factors in adapting to NIV, such as the use of drugs. The adaptation of the elderly user to NIV is influenced by socio-demographic, pathological, anatomical, and associated factors.