Crystal growth and soil expansion: The role of interfacial pressure and pore structure

AbstractThe citrate-based thermoset elastomer is a promising candidate for bone scaffold material, but the harsh curing condition made it difficult to fabricate porous structure. Recently, poly (1, 8-octanediol-co-Pluronic F127 citrate) (POFC) porous scaffold was creatively fabricated by chitin nanofibrils (ChiNFs) supported emulsion-freeze-casting. Thanks to the supporting role of ChiNFs, the lamellar pore structure formed by directional freeze-drying was maintained during the subsequent thermocuring. Herein, bioactive glass (BG) was introduced into the POFC porous scaffolds to improve bioactivity. It was found the complete replacement of ChiNF particles with BG particles could not form a stable porous structure; however, existing at least 15 wt% ChiNF could ensure the formation of lamellar pore, and the interlamellar distance increased with BG ratios. Thus, the BG granules did not contribute to the formation of pore structure like ChiNFs, however, they surely endowed the scaffolds with enhanced mechanical properties, improved osteogenesis bioactivity, better cytocompatibility as well as quick degradation rate. Reasonably adjusting BG ratios could balance the requirements of porous structure and bioactivity.

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On the Mechanism of Cuprate Crystal Growth: The Role of Mixed Metal Carbonates

Advanced Functional Materials ◽

10.1002/adfm.201501058 ◽

2015 ◽

Vol 25 (29) ◽

pp. 4700-4707 ◽

Cited By ~ 7

Author(s):

David C. Green ◽

Rebecca Boston ◽

Stefan Glatzel ◽

Martin R. Lees ◽

Stuart C. Wimbush ◽

...

Keyword(s):

Crystal Growth ◽

Mixed Metal ◽

Metal Carbonates

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Non-isothermal effectiveness factors and the role of heat transfer in crystal growth from solutions and melts

Chemical Engineering Science ◽

10.1016/0009-2509(91)80128-l ◽

1991 ◽

Vol 46 (1) ◽

pp. 183-192 ◽

Cited By ~ 22

Author(s):

Masakuni Matsuoka ◽

John Garside

Keyword(s):

Heat Transfer ◽

Crystal Growth ◽

Growth From Solutions ◽

Effectiveness Factors

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Crystallization modifiers applied in granite desalination: The role of the stone pore structure

Construction and Building Materials ◽

10.1016/j.conbuildmat.2009.10.031 ◽

2010 ◽

Vol 24 (5) ◽

pp. 766-776 ◽

Cited By ~ 32

Author(s):

T. Rivas ◽

E. Alvarez ◽

M.J. Mosquera ◽

L. Alejano ◽

J. Taboada

Keyword(s):

Pore Structure

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Particle Engineering: Fundamentals of Particle Formation and Crystal Growth

MRS Bulletin ◽

10.1557/mrs2006.207 ◽

2006 ◽

Vol 31 (11) ◽

pp. 881-886 ◽

Cited By ~ 17

Author(s):

Alfred Y. Lee ◽

Allan S. Myerson

Keyword(s):

Crystal Growth ◽

Dosage Form ◽

Decisive Role ◽

Product Performance ◽

Particle Engineering ◽

Particle Properties ◽

Packing Arrangement ◽

Form Development

AbstractThe engineering of particles with customized properties optimized for dosage form manufacture (tablet, capsule, ointment, etc.) has long been a goal of the pharmaceutical industry. Particles can be designed through modification in the size, morphology, and packing arrangement of the solids. The most common approach in achieving this is through crystallization. In this bottom-up process, the two main steps, nucleation and crystal growth, both play a decisive role in shaping the quality of the final crystalline product. In this review, the role of nucleation and crystal growth in controlling particle properties is discussed, and examples are provided that demonstrate the variation in solid-state properties as a function of size, habit (morphology), and internal structure of the particles. In addition, the role of particle properties in product performance and dosage form development of pharmaceuticals is also discussed.

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