Micro milling is gaining ground as the preferred process for the manufacture of micro/meso-scale components in conventional workpiece materials, in particular for miniature moulds and tooling inserts (~ 60HRC), for the plastics injection moulding industry. Following a brief literature review on microscale milling and associated machine tool/tooling developments, experimental results are presented in relation to spindle thermal growth for a compensated/cooled spindle operating at up to 60,000 rpm, designed to accommodate the machining of meso-scale/micro-scale components. The work involved investigation of spindle warm up and cool down rates for speeds ranging from 30,000 - 60,000 rpm and subsequently the evaluation of spindle growth using both non-contact and contact measuring systems. Growth levels of up to 16µm were detected despite active spindle cooling and the incorporation of a standard compensation algorithm within the control system. Modification to spindle acceleration and deceleration rates reduced error levels by up to 50%.