Luminescent Nanoparticle-Based Probes for Bioassays

ZnGa2O4:Cr3+ hemocompatibility was systematically investigated from the aspects of hemolysis, erythrocyte morphology, coagulation and complement system activation, and greatly improved by surface PEGylation.

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Lanthanide-doped upconverting luminescent nanoparticle platforms for optical imaging-guided drug delivery and therapy

Advanced Drug Delivery Reviews ◽

10.1016/j.addr.2012.05.007 ◽

2013 ◽

Vol 65 (5) ◽

pp. 744-755 ◽

Cited By ~ 221

Author(s):

Jie Shen ◽

Liang Zhao ◽

Gang Han

Keyword(s):

Drug Delivery ◽

Optical Imaging ◽

Luminescent Nanoparticle

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Luminescent nanoparticle trapping with far-field optical fiber-tip tweezers

Nanoscale ◽

10.1039/c5nr07727c ◽

2016 ◽

Vol 8 (9) ◽

pp. 5334-5342 ◽

Cited By ~ 14

Author(s):

Jean-Baptiste Decombe ◽

Francisco J. Valdivia-Valero ◽

Géraldine Dantelle ◽

Godefroy Leménager ◽

Thierry Gacoin ◽

...

Keyword(s):

Optical Fiber ◽

Far Field ◽

Luminescent Nanoparticle

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A Novel Complex: A Quantum Dot Conjugated to an Active T7RNA Polymerase

Journal of Nanomaterials ◽

10.1155/2013/468105 ◽

2013 ◽

Vol 2013 ◽

pp. 1-9 ◽

Cited By ~ 4

Author(s):

Mette Eriksen ◽

Peter Horvath ◽

Michael A. Sørensen ◽

Szabolcs Semsey ◽

Lene B. Oddershede ◽

...

Keyword(s):

Quantum Dot ◽

Rna Polymerase ◽

Single Molecule ◽

Rna Polymerases ◽

Fluorescent Signal ◽

Single Molecule Level ◽

Single Molecule Studies ◽

Novel Complex ◽

Luminescent Nanoparticle

To perform single-molecule studies of the T7RNA polymerase, it is crucial to visualize an individual T7RNA polymerase, for example, through a fluorescent signal. We present a novel complex combining two different molecular functions, an active T7RNA polymerase and a highly luminescent nanoparticle, a quantum dot. The complex has the advantage of both constituents: the complex can traffic along DNA and simultaneously be visualized, both at the ensemble and at the single-molecule level. The labeling was mediated through anin vivobiotinylation of a His-tagged T7RNA polymerase and subsequent binding of a streptavidin-coated quantum dot. Our technique allows for easy purification of the quantum dot labeled T7RNA polymerases from the reactants. Also, the conjugation does not alter the functionality of the polymerase; it retains the ability to bind and transcribe.

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Synthesis of luminescent nanoparticle embedded polymer nanocomposites for scintillation applications

MRS Proceedings ◽

10.1557/opl.2011.123 ◽

2011 ◽

Vol 1312 ◽

Cited By ~ 5

Author(s):

Thomas Rogers ◽

Chenlu Han ◽

Brent Wagner ◽

Jason Nadler ◽

Zhitao Kang

Keyword(s):

Polymer Matrix ◽

Gamma Ray ◽

Cost Effective ◽

Chemical Precipitation ◽

Precipitation Method ◽

Colloidal Solutions ◽

Index Matching ◽

Luminescent Nanoparticle ◽

Matrix Nanocomposite ◽

Selection Of

ABSTRACTDetecting gamma-ray emission from radionuclides hidden within containers is a significant concern to national security and can be accomplished with scintillating materials such as NaI:Tl, LaBr3:Ce crystals. However, the use of these high quality crystals limits the functionality of the detectors due to their high cost and scalability issues. Therefore the development of more durable, more easily manufactured, and more cost effective scintillating materials is desired. The incorporation of nanophosphors or Quantum Dots (QDs) into a polymer matrix to produce a transparent nanocomposite could potentially provide an alternative method to fabricate scintillating detectors. Embedded in a suitable polymer matrix, nanocomposite detectors may be easily made suitably large for portal monitors. Also, preparation of suitable particle sizes and/or compositions permits selection of a photon wavelength that optimally matches the photodetector response curve to increase the number of photons collected per pulse. In this paper a series of LaF3:Ce nanophosphors with varying doping concentrations (1–30mol%Ce) were synthesized using a chemical precipitation method. Photoluminescence and photoluminescence excitation characterizations indicated that the highest luminescent intensity was obtained from the 20%Ce doped sample with a peak emission at 325 nm. The refractive indices of the nanoparticles were identified by index matching measurements. Then an index matched epoxy was selected for incorporation of these nanoparticles to prepare transparent nanocomposite scintillators. In addition, colloidal solutions of CdTe QDs with various emitting colors were synthesized and incorporated into a Polymethyl-methacrylate (PMMA) matrix to make transparent nanocomposites. An initial evaluation of the scintillation behavior of these nanocomposites was evaluated by exposure to gamma rays.

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