Melatonin administration prevents cardiac and diaphragmatic mitochondrial oxidative damage in senescence-accelerated mice

Cardiac and diaphragmatic mitochondria from male SAMP8 (senescent) and SAMR1 (resistant) mice of 5 or 10 months of age were studied. Levels of lipid peroxidation (LPO), glutathione (GSH), GSH disulfide (GSSG), and GSH peroxidase and GSH reductase (GRd) activities were measured. In addition, the effect of chronic treatment with the antioxidant melatonin from 1 to 10 months of age was evaluated. Cardiac and diaphragmatic mitochondria show an age-dependent increase in LPO levels and a reduction in GSH:GSSG ratios. Chronic treatment with melatonin counteracted the age-dependent LPO increase and GSH:GSSG ratio reduction in these mitochondria. Melatonin also increased GRd activity, an effect that may account for the maintenance of the mitochondrial GSH pool. Total mitochondrial content of GSH increased after melatonin treatment. In general, the effects of age and melatonin treatment were similar in senescence-resistant mice (SAMR1) and SAMP8 cardiac and diaphragmatic mitochondria, suggesting that these mice strains display similar mitochondrial oxidative damage at the age of 10 months. The results also support the efficacy of long-term melatonin treatment in preventing the age-dependent mitochondrial oxidative stress.

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Cellular Dysfunction in Diabetes as Maladaptive Response to Mitochondrial Oxidative Stress

Experimental Diabetes Research ◽

10.1155/2012/696215 ◽

2012 ◽

Vol 2012 ◽

pp. 1-14 ◽

Cited By ~ 58

Author(s):

Alba Naudi ◽

Mariona Jove ◽

Victoria Ayala ◽

Anna Cassanye ◽

Jose Serrano ◽

...

Keyword(s):

Oxidative Stress ◽

Pathological State ◽

Physiological Mechanisms ◽

Mitochondrial Oxidative Stress ◽

Transport Chain ◽

Maladaptive Response ◽

Mitochondrial Oxidative Damage ◽

Cellular Dysfunction ◽

Intracellular Glucose

Oxidative stress has been implicated in diabetes long-term complications. In this paper, we summarize the growing evidence suggesting that hyperglycemia-induced overproduction of superoxide by mitochondrial electron transport chain triggers a maladaptive response by affecting several metabolic and signaling pathways involved in the pathophysiology of cellular dysfunction and diabetic complications. In particular, it is our goal to describe physiological mechanisms underlying the mitochondrial free radical production and regulation to explain the oxidative stress derived from a high intracellular glucose concentration and the resulting maladaptive response that leads to a cellular dysfunction and pathological state. Finally, we outline potential therapies for diabetes focused to the prevention of mitochondrial oxidative damage.

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Age-dependent increases in the oxidative damage of DNA, RNA, and their metabolites in normal and senescence-accelerated mice analyzed by LC–MS/MS: Urinary 8-oxoguanosine as a novel biomarker of aging

Free Radical Biology and Medicine ◽

10.1016/j.freeradbiomed.2012.02.016 ◽

2012 ◽

Vol 52 (9) ◽

pp. 1700-1707 ◽

Cited By ~ 54

Author(s):

Wei Gan ◽

Ben Nie ◽

Fei Shi ◽

Xin-Min Xu ◽

Jian-Chang Qian ◽

...

Keyword(s):

Oxidative Damage ◽

Age Dependent ◽

Senescence Accelerated Mice ◽

Biomarker Of Aging

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Chronic melatonin treatment reduces the age-dependent inflammatory process in senescence-accelerated mice

Journal of Pineal Research ◽

10.1111/j.1600-079x.2006.00416.x ◽

2007 ◽

Vol 42 (3) ◽

pp. 272-279 ◽

Cited By ~ 82

Author(s):

María I. Rodríguez ◽

Germaine Escames ◽

Luis C. López ◽

Ana López ◽

José A. García ◽

...

Keyword(s):

Inflammatory Process ◽

Melatonin Treatment ◽

Age Dependent ◽

Senescence Accelerated Mice

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Chronic melatonin treatment prevents age-dependent cardiac mitochondrial dysfunction in senescence-accelerated mice

Free Radical Research ◽

10.1080/10715760600936359 ◽

2007 ◽

Vol 41 (1) ◽

pp. 15-24 ◽

Cited By ~ 69

Author(s):

María I. Rodríguez ◽

Miguel Carretero ◽

Germaine Escames ◽

Luis C. López ◽

María D. Maldonado ◽

...

Keyword(s):

Mitochondrial Dysfunction ◽

Melatonin Treatment ◽

Age Dependent ◽

Senescence Accelerated Mice

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Melatonin Administration from 2000 to 2020 to Human Newborns with Hypoxic-Ischemic Encephalopathy

American Journal of Perinatology ◽

10.1055/s-0040-1719151 ◽

2020 ◽

Author(s):

Gabriella D'angelo ◽

Laura Cannavò ◽

Russel J. Reiter ◽

Eloisa Gitto

Keyword(s):

Oxidative Stress ◽

Clinical Trials ◽

Perinatal Asphyxia ◽

Hypoxic Ischemic Encephalopathy ◽

Melatonin Treatment ◽

The Past ◽

Melatonin Administration ◽

Key Points ◽

Ischemic Encephalopathy

Hypoxic-ischemic encephalopathy (HIE) is the main cause of long-term neurodevelopmental morbidity in term born infants worldwide. Melatonin is a hormone with antioxidant and anti-inflammatory effects that make it a promising molecule for the treatment of perinatal asphyxia. Probably, the synergistic use of hypothermia associated with melatonin treatment may improve the neurological outcome in infants with HIE. In the past 20 years, the efficacy of melatonin in reducing oxidative stress has been demonstrated in animals; however, clinical trials with sufficient sample size of newborns are lacking to date.Since in 2000 we were among the first to study the neuroprotective properties of melatonin on infants, in this review, we want to summarize the advantages and limitations of the investigations conducted to date. Key Points

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Long-term melatonin treatment for the prevention of ovarian aging

10.26226/morressier.573c1513d462b80296c98833 ◽

2016 ◽

Author(s):

Hiroshi Tamura

Keyword(s):

Melatonin Treatment ◽

Ovarian Aging

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COVID - 19 AND THE PROBLEM OF PERSONALITY

Natural resources of the Earth and environmental protection ◽

10.26787/nydha-2713-203x-2020-1-7-8-9-31-35 ◽

2020 ◽

pp. 31-35

Author(s):

Mazaeva N.A. ◽

Golovina A.G.

Keyword(s):

General Population ◽

Age Groups ◽

Personal Transformation ◽

Personality Changes ◽

Age Dependent

In order to determine possible trends in the dynamics and characterological structure of personality in the General population caused by the COVID-19 pandemic, which is a long-term strong stressful effect and clinically and psychopathologically comparable to chronic personality changes after experiencing a disaster, the conditions predisposing to personal transformation, including clinical and prognostic patterns, are analyzed. The age-dependent nature of these changes is shown, and a number of features identified for different age groups are discussed.

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JNK-mediated blockage of autophagic flux exacerbates the triethylene glycol dimethacrylate-induced mitochondrial oxidative damage and apoptosis in preodontoblast

Chemico-Biological Interactions ◽

10.1016/j.cbi.2021.109432 ◽

2021 ◽

Vol 339 ◽

pp. 109432

Author(s):

Konghuai Wang ◽

Qihao Yu ◽

Danni Wu ◽

Ruona Liu ◽

Xuekun Ren ◽

...

Keyword(s):

Oxidative Damage ◽

Triethylene Glycol ◽

Autophagic Flux ◽

Glycol Dimethacrylate ◽

Triethylene Glycol Dimethacrylate ◽

Mitochondrial Oxidative Damage

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Melatonin influences the early growth stage in Zoysia japonica Steud. by regulating plant oxidation and genes of hormones

Scientific Reports ◽

10.1038/s41598-021-91931-8 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Di Dong ◽

Mengdi Wang ◽

Yinreuizhi Li ◽

Zhuocheng Liu ◽

Shuwen Li ◽

...

Keyword(s):

Antioxidant Capacity ◽

Transcriptome Analysis ◽

Zoysia Japonica ◽

Hormone Activity ◽

Melatonin Treatment ◽

Regulatory Pathways ◽

Melatonin Administration ◽

Seed Growth ◽

Total Antioxidant ◽

Plant Life Cycle

AbstractZoysia japonica is a commonly used turfgrass species around the world. Seed germination is a crucial stage in the plant life cycle and is particularly important for turf establishment and management. Experiments have confirmed that melatonin can be a potential regulator signal in seeds. To determine the effect of exogenous melatonin administration and explore the its potential in regulating seed growth, we studied the concentrations of several hormones and performed a transcriptome analysis of zoysia seeds after the application of melatonin. The total antioxidant capacity determination results showed that melatonin treatment could significantly improve the antioxidant capacity of zoysia seeds. The transcriptome analysis indicated that several of the regulatory pathways were involved in antioxidant activity and hormone activity. The hormones concentrations determination results showed that melatonin treatment contributed to decreased levels of cytokinin, abscisic acid and gibberellin in seeds, but had no significant effect on the secretion of auxin in early stages. Melatonin is able to affect the expression of IAA (indoleacetic acid) response genes. In addition, melatonin influences the other hormones by its synergy with other hormones. Transcriptome research in zoysia is helpful for understanding the regulation of melatonin and mechanisms underlying melatonin-mediated developmental processes in zoysia seeds.

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