A Novel Colon-Specific Osmotic Pump Capsule of Panax notoginseng Saponins (PNS): Formulation, Optimization, and In Vitro-In Vivo Evaluation

2018 ◽  
Vol 19 (5) ◽  
pp. 2322-2329 ◽  
Author(s):  
Dong Jin ◽  
Bin Wang ◽  
Rongfeng Hu ◽  
Dan Su ◽  
Jiayi Chen ◽  
...  
Keyword(s):  
Panax Notoginseng ◽  
Osmotic Pump ◽  
Panax Notoginseng Saponins ◽  
In Vivo Evaluation ◽  
Formulation Optimization

Controlled delivery of carvedilol nanosuspension from osmotic pump capsule: In vitro and in vivo evaluation

2014 ◽  
Vol 475 (1-2) ◽  
pp. 496-503 ◽  
Author(s):  
Dandan Liu ◽  
Shihui Yu ◽  
Zhihong Zhu ◽  
Chunyang Lyu ◽  
Chunping Bai ◽  
...  
Keyword(s):  
Osmotic Pump ◽  
Controlled Delivery ◽  
In Vivo Evaluation

scholarly journals Design and evaluation of a novel floating osmotic pump system

2009 ◽  
Vol 12 (1) ◽  
pp. 129 ◽  
Author(s):  
Zhihong Zhang ◽  
Bo Peng ◽  
Xinggang Yang ◽  
Chao Wang ◽  
Guangmei Sun ◽  
...  
Keyword(s):  
Drug Release ◽  
Oral Administration ◽  
In Vitro Release ◽  
Osmotic Pump ◽  
Matrix Tablets ◽  
In Vivo Evaluation ◽  
Pump System ◽  
Conventional Tablet

PURPOSE. Find a novel delivery system for oral administration of drugs that have absorption window in the upper part of gastrointestinal (GI) track. METHODS. Dipyridamole was chosen as the model drug. A novel system, which combined the osmotic pump controlled release system and the floating system, was designed; matrix tablets (MT) were prepared for compares. The effects of pH, temperature and hydrodynamic conditions on drug release and the floating behavior of floating osmotic pump system (FOP) were investigated. In vivo evaluation was performed by a three-crossover study in six Beagle dogs relative to the conventional tablet (CT). Cumulative percent input in vivo was compared with that of in vitro release profiles. RESULTS. Floating behavior of FOP, drug releases from FOP and MT were sensitive to pH of dissolution media but not sensitive to temperature; the release of dipyridamole from MT was influenced by stirring rate while drug release from FOP was not. AUC of FOP was larger than MT and CT. The linear correlations between fraction absorbed in vivo and fraction dissolved in vitro was established for FOP-a true zero-order release formula, whereas only a nonlinear correlation was obtained for MT. CONCLUTIONS. FOP could be a novel way for the oral administration for drugs like dipyridamole.

scholarly journals Double-layered osmotic pump controlled release tablets of actarit: In vitro and in vivo evaluation

2019 ◽  
Vol 14 (3) ◽  
pp. 340-348 ◽  
Author(s):  
Yuenan Li ◽  
Hao Pan ◽  
Hongliang Duan ◽  
Jianting Chen ◽  
Zhihong Zhu ◽  
...  
Keyword(s):  
Controlled Release ◽  
Osmotic Pump ◽  
In Vivo Evaluation ◽  
Controlled Release Tablets

Panax notoginseng saponins provide neuroprotection by regulating NgR1/RhoA/ROCK2 pathway expression, in vitro and in vivo

2016 ◽  
Vol 190 ◽  
pp. 301-312 ◽  
Author(s):  
Xiaowei Shi ◽  
Wenjing Yu ◽  
Tiantian Yang ◽  
Wei Liu ◽  
Yizhou Zhao ◽  
...  
Keyword(s):  
Panax Notoginseng ◽  
Panax Notoginseng Saponins ◽  
Pathway Expression

Preparation and in vitro/in vivo evaluation of azilsartan osmotic pump tablets based on the preformulation investigation

2019 ◽  
Vol 45 (7) ◽  
pp. 1079-1088 ◽  
Author(s):  
Nini Li ◽  
Ling Fan ◽  
Biao Wu ◽  
Genlai Dai ◽  
Chengjun Jiang ◽  
...  
Keyword(s):  
Osmotic Pump ◽  
In Vivo Evaluation
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