Tablet Formulation of a Polymeric Solid Dispersion Containing Amorphous Alkalinized Telmisartan

2018 ◽  
Vol 19 (7) ◽  
pp. 2990-2999 ◽  
Author(s):  
Jun Soo Chae ◽  
Bo Ram Chae ◽  
Dong Jun Shin ◽  
Yoon Tae Goo ◽  
Eun Seok Lee ◽  
...  
Keyword(s):  
Solid Dispersion ◽  
Tablet Formulation ◽  
Polymeric Solid

scholarly journals Solid dispersion in the development of a nimodipine delayed-release tablet formulation

2014 ◽  
Vol 9 (1) ◽  
pp. 35-41 ◽  
Author(s):  
Yang Zhao ◽  
Tiegang Xin ◽  
Tiantian Ye ◽  
Xinggang Yang ◽  
Weisan Pan
Keyword(s):  
Solid Dispersion ◽  
Tablet Formulation ◽  
Delayed Release ◽  
Release Tablet

DESIGN AND OPTIMIZATION OF ORAL BIOADHESIVE NANOCURCUMIN DELIVERY USING NOVEL HYDROPHILIC CARRIER FOR CANCER TREATMENT: AN ALTERNATIVE TO PARENTERAL CHEMOTHERAPY

INDIAN DRUGS ◽  
2016 ◽  
Vol 53 (08) ◽  
pp. 24-36
Author(s):  
P. N Kendre ◽  
◽  
P. D. Chaudhari
Keyword(s):  
Solid Dispersion ◽  
Tablet Formulation ◽  
Fickian Diffusion ◽  
Release Mechanism ◽  
Design And Optimization ◽  
Drug Release Mechanism ◽  
Zero Order Kinetics ◽  
Time Period ◽  
Two Factors ◽  
Central Composite Designs

Present study involves the design and optimization of oral bioadhesive delivery system of curcumin. Solid dispersion of curcumin was developed using novel hydrophilic carrier, Gelucire® 50/13, by melt granulation technique. Based on HPMC K 100 LV(X1) and carbopol 934P (X2), bio-adhesive tablets containing curcumin solid dispersion was developed by direct compression, using central composite designs for two factors at three levels. Tablet formulation was optimized for t50%, Rel24h and bioadhesive strength. The drug release mechanism was found to be by fickian diffusion, approaching zero-order kinetics. Average plasma uptake of curcumin was found to be 0.289μg/mL as compared to plain curcumin tablet formulation. The results were found highly significant (p<0.05). The swelling matrices behavior over the time period studied showed that the gelling layer thickness increases continuously. From this study, it may be concluded that the oral controlled bioadhesive curcumin delivery may be an alternative to parenteral chemotherapy.

scholarly journals Formulation and Evaluation of Gliclazide Solid Dispersions Incorporated Tablets for Controlled Drug Release

2020 ◽  
pp. 621-629
Author(s):  
Ramisetty Sunitha ◽  
Kothakota Venugopal ◽  
Suggala Venkata Satyanarayana
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Solid Dispersion ◽  
Release Kinetics ◽  
Maximum Yield ◽  
Amorphous State ◽  
Tablet Formulation ◽  
Drug Dissolution ◽  
Fickian Diffusion ◽  
Drug Content

The current study deals with formulation and evaluation of gliclazide solid dispersion with HP β Cyclodextrin to enhance solubility and incorporate into tablet formulation for controlled release of gliclazide. Gliclazide solid dispersion (SD) prepared using varying ratios of HP β Cyclodextrin and evaluated. The optimized SD formulation incorporated into tablet by using hydroxypropyl cellulose, HPMC K 100M. The drug dissolution from tablet formulation analyzed and characterize. The formulation SD3 comprising of drug and polymer in 1:3 ratio displayed 43-fold increase in solubility when compared to pure drug. The formulation SD13 displayed maximum yield of 98.96% and maximum drug content of 99% chosen optimal for tablet formulation. FTIR studies revealed that there is no incompatibility between drug and polymers found. XRD studies revealed that the optimized solid dispersion formulation was found to be in amorphous state. Around 15 formulations of controlled release tablet blends evaluated for micrometric properties show that all the formulations posses’ good flow properties. Formulation F15 with maximum drug content of 99.99% and drug release of 99.96 % over 16h was chosen optimal and characterized. The release kinetics suggest that drug release followed zero order and release from tablets was anomalous non- fickian diffusion super case II transport. The results show that combination of solid dispersion and application of hydrophilic and hydrophobic polymers in matrix formation can facilitate better dissolution and absorption profile with greater patient compliance.

scholarly journals FORMULATION AND EVALUATION OF IBUPROFEN CONTROLLED RELEASE MATRIX TABLETS USING ITS SOLID DISPERSION

2019 ◽  
pp. 71-76 ◽  
Author(s):  
SREEJAN MANNA ◽  
JYOSHNA KOLLABATHULA
Keyword(s):  
Controlled Release ◽  
Solid Dispersion ◽  
Aqueous Solubility ◽  
Tablet Formulation ◽  
Matrix Tablets ◽  
Peg 6000 ◽  
Sem Image ◽  
Hydrophobic Polymers ◽  
Ft Ir ◽  
Ir Study

Objective: The aim of the present work was to prepare solid dispersion of ibuprofen with PEG 6000 to increase the aqueous solubility of the drug and to develop the solid dispersed ibuprofen into tablet formulation with the combination of a hydrophilic and hydrophobic polymer to attain controlled release of ibuprofen. Methods: Solid dispersion of ibuprofen was prepared by melting-solvent method by varying the ratio of drug and PEG 6000. The solid dispersed ibuprofen was subjected to tablet formulation by using a hydrophilic swellable polymer-carbopol and hydrophobic non-swellable polymer-ethyl cellulose. The release of the drug from the polymer matrix was studied as the polymer ratio changes. Results: Compatibility between drug and polymers was established from FT-IR study. The saturated solubility was found to increase in the solid dispersed formulation. The swelling index was found within the range of 90±5.43 to 137±6.41. SEM image of swollen tablet confirmed the presence of irregular and porous surface. The cumulative drug release was found to vary within the range of 68.76±3.04 to 95.33±2.34 % after 8 h of dissolution. Conclusion: The combination of solid dispersion and application of hydrophilic and hydrophobic polymers in matrix formation can facilitate better dissolution and absorption profile with greater patient compliance.

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