Progesterone as a Bone-Trophic Hormone

1990 ◽  
Vol 11 (2) ◽  
pp. 386-398 ◽  
Author(s):  
J. C. PRIOR
Keyword(s):  
Trophic Hormone

Control of growth in the rat thyroid-an example of specific desensitization to trophic hormone stimulation

1983 ◽  
Vol 39 (4) ◽  
pp. 421-423 ◽  
Author(s):  
D. Wynford-Thomas ◽  
B. M. J. Stringer ◽  
H. R. Harach ◽  
E. D. Williams
Keyword(s):  
Hormone Stimulation ◽  
Rat Thyroid ◽  
Trophic Hormone

β-endorphin is a kidney trophic hormone

Life Sciences ◽  
1979 ◽  
Vol 25 (7) ◽  
pp. 615-620 ◽  
Author(s):  
Mari K. Haddox ◽  
Diane Haddock Russell
Keyword(s):  
Trophic Hormone

OESTRADIOL-17β AND TESTOSTERONE IN RAT TESTIS TISSUE: EFFECT OF GONADO-TROPHINS, LOCALIZATION AND PRODUCTION IN VITRO

1974 ◽  
Vol 60 (3) ◽  
pp. 409-419 ◽  
Author(s):  
F. H. de JONG ◽  
A. H. HEY ◽  
H. J. van der MOLEN
Keyword(s):  
Intravenous Injection ◽  
Testicular Tissue ◽  
Prolonged Treatment ◽  
Seminiferous Tubules ◽  
Interstitial Tissue ◽  
Tissue Concentrations ◽  
Hypophysectomized Rats ◽  
Trophic Hormone ◽  
Testis Tissue

SUMMARY Concentrations of oestradiol-17β and testosterone were estimated in testicular tissue from intact and hypophysectomized rats. Within 30 min after intravenous injection of human chorionic gonadotrophin (HCG) or follicle-stimulating hormone (FSH) to intact animals the tissue concentrations of both steroids were not significantly changed. Prolonged s.c. administration of HCG (5 days) caused an increase in the tissue levels of both steroids, which was further increased when the prolonged treatment was followed by an intravenous injection with this trophic hormone. FSH had no influence on tissue concentrations of oestradiol-17β or testosterone in hypophysectomized rats. Assay of separated seminiferous tubules and interstitial tissue indicated that oestradiol-17β and testosterone were mainly localized in the interstitial tissue. Incubations of these constituents showed that oestradiol-17β was produced in the seminiferous tubules, while testosterone was produced in the interstitial compartment.

Activity of LH receptor, LH-stimulated cyclic AMP and testosterone production in the Leydig cell of heat-acclimatized rats

1984 ◽  
Vol 102 (2) ◽  
pp. 167-173 ◽  
Author(s):  
E. Bedrak ◽  
Z. Chap
Keyword(s):  
Relative Humidity ◽  
Cyclic Amp ◽  
Leydig Cell ◽  
Male Rats ◽  
Heat Acclimatization ◽  
Lh Receptor ◽  
Hot Environment ◽  
C 30 ◽  
Lower Capacity ◽  
Trophic Hormone

ABSTRACT Key reactions associated with the capacity of the isolated Leydig cell to synthesize testosterone were studied in male rats acclimatized to a hot environment (33–35 °C, 25–40% relative humidity) and controls (20–22 °C, 30–50% relative humidity). The results demonstrate that acclimatization to heat coincides with: (1) a lower number of human chorionic gonadotrophin (hCG) receptors (P<0·01) in the Leydig cell, (2) higher affinity of the Leydig cell for hCG (P < 0·05), (3) lower hCG-stimulated cyclic AMP production (P<0·05) by the Leydig cell and (4) lower capacity of the Leydig cell to synthesize testosterone (P<0·01) after hCG challenge. It is suggested that the major cellular alteration responsible for the decreased testosterone secretion by the Leydig cell lies distal to the step involving the binding of the trophic hormone to its receptor and that heat-acclimatization induces changes in the integrity of the various cellular membranes leading to the impeded function of adenylate cyclase and 17β-hydroxysteroid oxidoreductase. J. Endocr. (1984) 102, 167–173

THE EFFECT OF PROPYLTHIOURACIL ON THE WEIGHT AND CONCENTRATIONS OF CHOLESTEROL AND ASCORBIC ACID OF THE ADRENAL GLAND

1952 ◽  
Vol 30 (1) ◽  
pp. 36-41
Author(s):  
William F. Perry
Keyword(s):  
Ascorbic Acid ◽  
Adrenal Gland ◽  
Adrenal Glands ◽  
Weight Basis ◽  
Weight Changes ◽  
Body Weight Changes ◽  
Gland Weight ◽  
And Control ◽  
Pituitary Adrenal Axis ◽  
Trophic Hormone

The effect on the rat adrenal gland of massive doses of propylthiouracil over a three-week period has been studied. Care was taken to have any body weight changes of the treated animals paralleled by similar changes in the control, animals. Under these circumstances it was found that on a gland weight basis no atrophy of the adrenal glands occurred. There were however alterations in the adrenal cholesterol and ascorbic acid concentrations, there being an increase in the former and a decrease in the latter and further these changes were not dependent upon any hypometabolism induced by the thiouracil. The level of the adrenal cholesterol and ascorbic acid concentrations measured three hours after injection of ACTH and of epinephrine indicated that the adrenal cortex was responsive to its trophic hormone and that the pituitary–adrenal axis was intact, the degree of response being similar in both treated and control animals.

TROPHIC HORMONE CONTENT OF THE ANTERIOR LOBE OF THE PITUITARY GLAND IN NORMAL AND CASTRATE MALE DOGS

1960 ◽  
Vol XXXIV (II) ◽  
pp. 169-175 ◽  
Author(s):  
Julian M. Davidson ◽  
Alexander N. Contopoulos ◽  
William F. Ganong
Keyword(s):  
Pituitary Gland ◽  
Anterior Pituitary ◽  
Fold Increase ◽  
Response Characteristic ◽  
Anterior Lobe ◽  
Female Rats ◽  
Immature Female ◽  
Castrate Male ◽  
Effective Doses ◽  
Trophic Hormone

ABSTRACT Pituitary FSH, ICSH, and TSH activities of intact and castrate male dogs were assayed in hypophysectomized immature female rats by determining the minimum amount of anterior pituitary tissue necessary to produce a response characteristic of each of these hormones. In intact dogs only, pituitary ACTH and GH content were also determined. The minimum effective doses obtained for intact dogs in fractions of anterior pituitary were: FSH – 1.5, ICSH – 0.25, TSH – 0.016, ACTH – 0.025, GH – 0.125. Castration had no significant effect on TSH content, but resulted in a sixteen-fold increase in FSH content and a two-fold increase in ICSH content of the pituitary gland.

EFFECT OF LEVODOPA (L-DOPA) ON HUMAN HYPOPHYSEAL TROPHIC HORMONE RELEASE1

1971 ◽  
Vol 33 (4) ◽  
pp. 709-712 ◽  
Author(s):  
R. L. EDDY ◽  
A. L. JONES ◽  
Z. H. CHAKMAKJIAN ◽  
M. C. SILVERTHORNE
Keyword(s):  
Trophic Hormone
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