scholarly journals Insulin-Induced Phosphorylation and Activation of Phosphodiesterase 3B in Rat Adipocytes: Possible Role for Protein Kinase B But Not Mitogen-Activated Protein Kinase or p70 S6 Kinase*

Endocrinology ◽  
1998 ◽  
Vol 139 (1) ◽  
pp. 219-227 ◽  
Author(s):  
Jonny Wijkander ◽  
Tova Rahn Landström ◽  
Vincent Manganiello ◽  
Per Belfrage ◽  
Eva Degerman
Keyword(s):  
Protein Kinase ◽  
Protein Kinase B ◽  
Mitogen Activated Protein Kinase ◽  
S6 Kinase ◽  
P70 S6 Kinase ◽  
Rat Adipocytes ◽  
Mitogen Activated Protein ◽  
Phosphodiesterase 3B

scholarly journals Ganglioside GM1 Activates the Mitogen-Activated Protein Kinase Erk2 and p70 S6 Kinase in U-1242 MG Human Glioma Cells

2002 ◽  
Vol 69 (1) ◽  
pp. 116-125 ◽  
Author(s):  
James R. Van Brocklyn ◽  
J. R. Vandenheede ◽  
Richard Fertel ◽  
Allan J. Yates ◽  
Arfaan A. Rampersaud
Keyword(s):  
Protein Kinase ◽  
Glioma Cells ◽  
Mitogen Activated Protein Kinase ◽  
Human Glioma ◽  
Human Glioma Cells ◽  
Ganglioside Gm1 ◽  
S6 Kinase ◽  
P70 S6 Kinase ◽  
Mitogen Activated Protein

Recombinant globular adiponectin inhibits lipid deposition by p38 MAPK/ATF-2 and TOR/p70 S6 kinase pathways in chicken adipocytes

2014 ◽  
Vol 92 (1) ◽  
pp. 53-60 ◽  
Author(s):  
Yan Jun ◽  
Tan Xiao ◽  
Yan Guoyong ◽  
Feng Min ◽  
Yang Haili ◽  
...  
Keyword(s):  
P38 Mapk ◽  
Fatty Acid Synthase ◽  
Marker Gene ◽  
Mitogen Activated Protein Kinase ◽  
Marker Genes ◽  
Lipid Deposition ◽  
S6 Kinase ◽  
P70 S6 Kinase ◽  
Mitogen Activated Protein ◽  
Globular Adiponectin

Adiponectin plays a fundamental role in lipid and carbohydrate metabolism. However, its role in adipocyte differentiation remains controversial. To investigate the effect of gAd on lipid deposition in chicken adipocytes and its related signaling pathways, 200 μg/mL recombinant globular adiponectin, isoproterenol, SB253580, leucine, and rapamycin were used to treat chicken adipocytes. Results demonstrated that gAd increased the expression of endogenous adiponectin and AdipoR1 (P < 0.01); gAd inhibited triglyceride (TG) accumulation in chicken adipocyte and increased the release of free fatty acids (FFA) in medium; gAd decreased the expression of adipogenic marker genes CCAAT/enhancer binding protein alpha (C/EBPα) and fatty acid synthase (FAS), while activating the expression of lipolytic marker gene adipose triglyceride lipase (ATGL) (P < 0.01). Meanwhile, gAd activated the phosphorylation levels of p38 mitogen-activated protein kinase (p38 MAPK) and activating transcription factor 2 (ATF-2), and suppressed the phosphorylation levels of rapamycin (TOR) and p70 S6 Kinase (P < 0.01). In conclusion, the results demonstrate that gAd has an ability to inhibit lipids deposition in chicken adipocyte, which depends on the p38 MAPK/ATF–2 and TOR/p70 S6 Kinase pathways.

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