scholarly journals Leptin and Bone Mineral Density: A Cross-Sectional Study in Obese and Nonobese Men

2003 ◽  
Vol 88 (12) ◽  
pp. 5795-5800 ◽  
Author(s):  
Cathrine M. Morberg ◽  
Inge Tetens ◽  
Eva Black ◽  
Soeren Toubro ◽  
Thorkild I. A. Soerensen ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Body Mass Index ◽  
Lean Body Mass ◽  
Body Mass ◽  
Bone Mineral ◽  
Fat Mass ◽  
Control Group ◽  
Mineral Density ◽  
Cross Sectional ◽  
Serum Leptin

Abstract Leptin has been suggested to decrease bone mineral density (BMD). This observational analysis explored the relationship between serum leptin and BMD in 327 nonobese men (controls) (body mass index 26.1 ± 3.7 kg/m2, age 49.9 ± 6.0 yr) and 285 juvenile obese men (body mass index 35.9 ± 5.9 kg/m2, age 47.5 ± 5.1 yr). Whole-body dual-energy x-ray absorptiometry scan measured BMD, fat mass, and lean mass. Fasting serum leptin (nanograms per milliliter) was strongly associated with fat mass (kilograms) in both controls (r = 0.876; P < 0.01) and juvenile obese (r = 0.838; P < 0.001). An inverse relation between BMD adjusted for body weight and serum leptin emerged in both the control group (r = −0.186; P < 0.01) and the juvenile obese group (r = −0.135; P < 0.05). In a multiple linear regression, fat mass, lean body mass, and occupational physical activity were positively associated with BMD in the control group, whereas in the juvenile obese, only lean body mass was positively associated with BMD and smoking negatively associated with BMD. Our study supports that leptin is inversely associated with BMD and may play a direct role in the bone metabolism in nonobese and obese Danish males, but it also stresses the fact that the strong covariation between the examined variables is a shortcoming of the cross-sectional design.

Female boxers have high bone mineral density despite low body fat mass, high energy expenditure, and a high incidence of oligomenorrhea

2008 ◽  
Vol 33 (5) ◽  
pp. 863-869 ◽  
Author(s):  
Barbara Trutschnigg ◽  
Chin Chong ◽  
Lucia Habermayerova ◽  
Antony D. Karelis ◽  
Joanna Komorowski
Keyword(s):  
Bone Mineral Density ◽  
Energy Expenditure ◽  
Lean Body Mass ◽  
Body Mass ◽  
Body Fat ◽  
Bone Mineral ◽  
Fat Mass ◽  
Body Fat Mass ◽  
Mineral Density ◽  
Menstrual Status

Low body fat mass and menstrual irregularities have been associated with low bone mineral density (BMD). The aim of this study was to compare the relation between BMD, lean body mass, fat mass, physical activity energy expenditure (PAEE), and menstrual status in female boxers and in physically active females with low (C1) or average (C2) fat mass. Boxers (n = 11) and controls (C1, n = 16; C2, n = 17), aged 18–38 years, were assessed for BMD and body composition with dual-energy X-ray absorptiometry. Menstrual status and PAEE were determined from questionnaires. There was no difference in anthropometric measurements between boxers and C1 subjects, except that boxers had higher arm lean mass. However, both boxers and C1 subjects had a lower percentage of fat (p < 0.001) than C2 subjects (boxers, 14.6% ± 2.0; C1, 15.5% ± 4.2; C2, 25.8% ± 3.4%), and boxers had a higher (p = 0.002) lean body mass index (lean body mass/height2, where lean body mass is measured in kilograms and height is measured in metres) than C2 subjects. The PAEE of boxers was higher (p < 0.007) than that of controls (boxers, 5748 ± 2284 ; C1, 2966 ± 2258 ; C2, 2714 ± 1722 kcal·week–1). Oligomenorrhea was more common in boxers than in C1 and C2 subjects (boxers, 54.6%; C1, 18.8%; C2, 35.3%). Arm, leg, and spine BMD were higher (p < 0.008) in boxers than in C1 subjects, and arm BMD was higher in boxers than in C2 subjects. BMD Z scores were also higher (p < 0.05) in boxers (boxers, 1.1± 0.8, C1, 0.1 ± 0.7; C2: 0.3 ± 1.1). High BMD in boxers, despite low fat mass, high PAEE, and an increased incidence of oligomenorrhea suggest that boxing has a positive effect on BMD.

scholarly journals Bone Mineral Density and Body Mass Index in Postmenopausal Women

2021 ◽  
Vol 49 (3) ◽  
pp. 22-28
Author(s):  
Kamrun Nahar ◽  
Mohammed Mehedi Al Zahid Bhuiyan ◽  
Md Azzad Mia ◽  
Arshad Hossain ◽  
Humayra Tasnim
Keyword(s):  
Bone Mineral Density ◽  
Body Mass Index ◽  
Lumbar Spine ◽  
Postmenopausal Women ◽  
Body Mass ◽  
Bone Mineral ◽  
Age Group ◽  
Mineral Density ◽  
Cross Sectional ◽  
Left Femur

Osteoporosis is a typical medical issue that overwhelmingly influences postmenopausal women. A bone density test is the only test that can diagnose osteoporosis before a broken bone occurs. The aims of this study was to find out the relationship between bone mineral density (BMD) and body mass index (BMI) in postmenopausal females. This cross sectional descriptive study was carried out in the Institute of Nuclear Medicine and Allied Sciences (INMAS), Sylhet. Study subjects comprised of 117 postmenopausal women between ages 45 to 85 years, with a mean age of 60.8 ± 9.2 years, who underwent BMD scan from January 2018 to June 2019. Duration of the study was 5 months ( march 2019 to august 2019). BMD was measured by the MedilinkMedix DR system. Findings of BMD of right femur showed osteopenia and osteoporosis (low BMD) in most of the women with under weight (81.0%) about one third  (32.3%) of normal body weight and few (16.7%) of them over weight. Contrarily in left femur, low BMD was found in 08 (80.0%), 25 (40.3%) and 6 (16.7%) among underweight, normal, overweight patients respectively.   According to BMI compare to the lumbar spine, low BMD was found in 48 (77.4%), 10 (100 %), 20 (55.6%), 03 (33.3%) among normal, underweight, overweight, and obese patients respectively. Relationship among BMD and BMI was found statistically significant in the both femurs (p < 0.001) and lumbar spine (p = 0.02). Low BMD was more severe in the 65-74 years’ age group in both femurs 65.4% and 65-85 years’ age group in lumbar spine 84.6% compare to other groups. The findings of this study reveal that low BMI and aging are associated with bone loss. Routine BMD checking in postmenopausal women might be important to initiate an early clinical intervention for osteoporosis. Bangladesh Med J. 2020 Sept; 49(3) : 22-28

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