Presence of Luteinizing Hormone/Human Chorionic Gonadotropin Receptors in Male Breast Tissues

Receptors for LH/human chorionic gonadotropin (hCG) have been found in a variety of nongonadal tissues including the female breast. Using in situ hybridization and immunohistochemistry, we demonstrated the presence of LH/hCG receptor mRNA and protein in normal male breast tissue obtained at autopsy (n = 4) and archival samples of benign gynecomastia (n = 14) and male breast carcinoma (n = 5). Although the function of these receptors remains to be determined, the findings suggest the possibility that LH and hCG may play a role in the pathogenesis of male breast disorders.

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Granulomatous Mastitis: A Rare Cause of Male Breast Lump

Case Reports in Oncology ◽

10.1159/000448990 ◽

2016 ◽

Vol 9 (2) ◽

pp. 516-519 ◽

Cited By ~ 12

Author(s):

Abdel Rahman A. Al Manasra ◽

Mohammad F. Al-Hurani

Keyword(s):

Breast Tissue ◽

Nipple Discharge ◽

Surgical Excision ◽

Male Breast ◽

Granulomatous Mastitis ◽

Idiopathic Granulomatous Mastitis ◽

Radiologic Findings ◽

Female Breast ◽

The Right ◽

Histopathologic Findings

Background: Mastitis is a common benign disorder of the female breast. It is frequently associated with tenderness, swelling and nipple discharge. We are describing an extremely rare case of an idiopathic granulomatous mastitis in the male breast. Only 1 previous case was reported. Case Report: A 29-year-old male patient presented with a hard, painless lump in the right breast of 2 weeks duration. The patient underwent surgical excision with margin. The histopathologic findings were consistent with granulomatous mastitis. The case was reported as idiopathic granulomatous mastitis after exclusion of all known causes of the disease. Conclusion: Granulomatous mastitis is rare in females and extremely rare in male breast tissue. Since this disease mimics breast cancer in its clinical picture and radiologic findings are usually not conclusive, surgical excision is recommended in all cases.

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Human chorionic gonadotropin improves endometrial receptivity by increasing the expression of homeobox A10

MHR Basic science of reproductive medicine ◽

10.1093/molehr/gaaa026 ◽

2020 ◽

Vol 26 (6) ◽

pp. 413-424

Author(s):

Mengchen Zhu ◽

Shanling Yi ◽

Xiaomin Huang ◽

Junan Meng ◽

Haixiang Sun ◽

...

Keyword(s):

Chorionic Gonadotropin ◽

Human Chorionic Gonadotropin ◽

Embryo Implantation ◽

Endometrial Receptivity ◽

Endometrial Stromal Cells ◽

Healthy Control ◽

Hcg Receptor ◽

Methyltransferase 1

Abstract Homeobox A10 (HOXA10) is a characterized marker of endometrial receptivity. The mechanism by which hCG intrauterine infusion promotes embryo implantation is still unclear. This study seeks to investigate whether hCG improves endometrial receptivity by increasing expression of HOXA10. HOXA10 expression with human chorionic gonadotropin stimulation was analyzed in vitro and in vivo. Our results demonstrate that HOXA10 was decreased in the endometria of recurrent implantation failure patients compared to that in the healthy control fertile group, also we observed that hCG intrauterine infusion increased endometrial HOXA10 expression. HOXA10, blastocyst-like spheroid expansion area was increased, whereas DNA (cytosine-5-)-methyltransferase 1 was decreased when human endometrial stromal cells (hESCs) were treated with 0.2 IU/ml of hCG for 48 h. HOXA10 promoter methylation was also reduced after hCG treatment. Collagen XV (ColXV) can repress the expression of DNA (cytosine-5-)-methyltransferase 1, and hCG treatment increased the expression of ColXV. However, when the hESCs were treated with LH/hCG receptor small interfering RNA to knock down LH/hCG receptor, hCG treatment failed to repress DNA (cytosine-5-)-methyltransferase 1 expression or to increase ColXV expression. Our findings suggest that hCG may promote embryo implantation by increasing the expression of HOXA10.

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Expression and Localization of Secreted Frizzled-Related Protein-4 in the Rodent Ovary: Evidence for Selective Up-Regulation in Luteinized Granulosa Cells

Endocrinology ◽

10.1210/en.2003-0048 ◽

2003 ◽

Vol 144 (10) ◽

pp. 4597-4606 ◽

Cited By ~ 55

Author(s):

Minnie Hsieh ◽

Sabine M. Mulders ◽

Robert R. Friis ◽

Arun Dharmarajan ◽

JoAnne S. Richards

Keyword(s):

Chorionic Gonadotropin ◽

Granulosa Cells ◽

Human Chorionic Gonadotropin ◽

Follicular Development ◽

Corpora Lutea ◽

Related Protein ◽

Rich Domain ◽

And Function ◽

Periovulatory Follicles

Secreted frizzled-related protein-4 (sFRP-4) belongs to a family of soluble proteins that have a Frizzled-like cysteine-rich domain and function as modulators of Wnt-Frizzled (Fz) signals. As several Wnts and Fz are expressed at defined stages of follicular development in rodent ovaries, these studies were undertaken to evaluate the hormone-regulated expression and localization of sFRP-4. In the mouse ovary, the expression of sFRP-4 mRNA was up-regulated in granulosa cells of large antral follicles after human chorionic gonadotropin administration and was also elevated in corpora lutea, as determined by RT-PCR and in situ hybridization analyses. In hypophysectomized rat ovaries, sFRP-4 expression was similarly induced by human chorionic gonadotropin and further up-regulated by PRL. PRL also stimulated the secretion of sFRP-4 protein from luteinized rat granulosa cells in culture. Therefore, regulation of sFRP-4 by LH and PRL may be important for modulating Fz-1, which is known to be expressed in periovulatory follicles, and Wnt-4/Fz-4, which are expressed in corpora lutea.

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