26. Effect of human chorionic gonadotropin (hCG) on the immunological system of normal male rats

1992 ◽  
Vol 16 (1) ◽  
pp. VIII-IX
Keyword(s):  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Male Rats ◽  
Normal Male ◽  
Immunological System

scholarly journals Potential role of human chorionic gonadotropin supplementation in spermatogenesis in rats subjected to forced swimming exercise

Folia Medica ◽  
2021 ◽  
Vol 63 (5) ◽  
pp. 710-719
Author(s):  
Ardeshir Moayeri ◽  
Marzieh Darvishi ◽  
Hatef Ghasemi Hamidabadi ◽  
Sina Mojaverrostami
Keyword(s):  
Chorionic Gonadotropin ◽  
Adult Male ◽  
Human Chorionic Gonadotropin ◽  
Sperm Quality ◽  
Exercise Group ◽  
Forced Swimming ◽  
Male Rats ◽  
Swimming Exercise ◽  
Control Group ◽  
Tunel Staining

Aim: The aim of this study was to evaluate the supportive effect of human chorionic gonadotropin (hCG) on the quality of spermatogenesis, including count, motility, morphology, viability and apoptosis of sperm following forced swimming exercise. Materials and methods: Twenty-four adult male Sprague-Dawley rats were used in this study. All rats were divided into four groups: control group; swimming exercise group (S); hCG administration group and swimming (SG) with hCG administration group (G). The experimental group was trained to force swimming stress for 10 min for 6 days. Then the sperm quality parameters were measured after dissection and epididymis removal. Spermatogenesis and germ cell apoptosis were evaluated by using Miller & Johnsen’s score and TUNEL staining respectively. Results: Results showed the count (control: 113±3.1, S: 74±1.9, G: 111±3, and SG: 103±2.4), motility (control:  93±2, S: 67±2.8,G: 90±2.7, and SG: 78±1), morphology (control: 89±3%, S: 47±2.4%, G: 90±3.1%, and SG: 67±1.1%), and viability of sperm (control: 91±2.9, S: 50±2, G: 91±1.9, and SG: 70±1.3) in swimming exercised-hCG administered group, significantly enhanced by hCG treatment compared to the swimming exercise group (p≤0.01). Also the number of apoptotic germ cells significantly decreased in swimming exercised-hCG administered group compared to the swimming exercised group. Conclusions: These results suggest that administration of hCG can protect the testes against the detrimental effect of forced swimming exercise in adult male rats.

scholarly journals Presence of Luteinizing Hormone/Human Chorionic Gonadotropin Receptors in Male Breast Tissues

2004 ◽  
Vol 89 (8) ◽  
pp. 4119-4123 ◽  
Author(s):  
Harold E. Carlson ◽  
Philip Kane ◽  
Z. M. Lei ◽  
X. Li ◽  
C. V. Rao
Keyword(s):  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Breast Tissue ◽  
Male Breast ◽  
Normal Male ◽  
Receptor Mrna ◽  
Female Breast ◽  
Breast Tissues ◽  
Hcg Receptor

Receptors for LH/human chorionic gonadotropin (hCG) have been found in a variety of nongonadal tissues including the female breast. Using in situ hybridization and immunohistochemistry, we demonstrated the presence of LH/hCG receptor mRNA and protein in normal male breast tissue obtained at autopsy (n = 4) and archival samples of benign gynecomastia (n = 14) and male breast carcinoma (n = 5). Although the function of these receptors remains to be determined, the findings suggest the possibility that LH and hCG may play a role in the pathogenesis of male breast disorders.

scholarly journals Bisphenol A inhibits testicular response to human chorionic gonadotropin in adult male rats

2000 ◽  
Vol 82 ◽  
pp. 58
Author(s):  
Atsushi Tohei ◽  
Satoshi Suda ◽  
Hiroshi Koibuchi ◽  
Kazuhiro Tamura ◽  
Hideo Honda ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Chorionic Gonadotropin ◽  
Adult Male ◽  
Human Chorionic Gonadotropin ◽  
Male Rats

Differential effects of the administration of human chorionic gonadotropin to postnatal rats

1994 ◽  
Vol 142 (3) ◽  
pp. 527-534 ◽  
Author(s):  
F Gaytan ◽  
L Pinilla ◽  
J L Romero ◽  
E Aguilar
Keyword(s):  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Leydig Cells ◽  
Reproductive Function ◽  
Male Rats ◽  
Testicular Development ◽  
Long Term Effects ◽  
Adult Type ◽  
Short And Long Term

Abstract Neonatal and prepubertal male rats were treated with human chorionic gonadotropin (hCG, 5 IU/g body weight per day) on days 2–4 or 20–22. Depending on the date of treatment, different groups of rats were sacrificed at 5, 23, 30 and 100 days of age, in order to study the short-and long-term effects of the treatment with hCG on the development of the testes and sex accessory organs. Rats treated with hCG on days 2–4 showed increased number and size of foetal Leydig cells at 5 days of age. However, long-term effects include decreased numbers of adult-type Leydig cells, decreased weight of the testes and sex accessory organs, decreased basal and hCG-stimulated testosterone secretion, and delayed balano-preputial separation. In contrast, animals treated with hCG on days 20–22 showed similar short- and long-term effects, consisting of increased number of adult-type Leydig cells and macrophages, increased weight of the testes and sex accessory organs and advanced balano-preputial separation. In adulthood, both groups showed normal reproductive function. These results seem to indicate that the effects of hCG treatment in prepubertal rats are dependent on the type of Leydig cell stimulated, and suggest that foetal Leydig cells play a regulatory role in the early postnatal testicular development. Journal of Endocrinology (1994) 142, 527–534

scholarly journals Comparative Study of the Steroidogenic Effects of Human Chorionic Gonadotropin and Thieno[2,3-D]pyrimidine-Based Allosteric Agonist of Luteinizing Hormone Receptor in Young Adult, Aging and Diabetic Male Rats

2020 ◽  
Vol 21 (20) ◽  
pp. 7493
Author(s):  
Andrey A. Bakhtyukov ◽  
Kira V. Derkach ◽  
Maxim A. Gureev ◽  
Dmitry V. Dar’in ◽  
Viktor N. Sorokoumov ◽  
...  
Keyword(s):  
Gene Expression ◽  
Young Adult ◽  
Luteinizing Hormone ◽  
Comparative Study ◽  
Adenylyl Cyclase ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Male Rats ◽  
Testicular Steroidogenesis ◽  
Adult Aging

Low-molecular-weight agonists of luteinizing hormone (LH)/human chorionic gonadotropin (hCG) receptor (LHCGR), which interact with LHCGR transmembrane allosteric site and, in comparison with gonadotropins, more selectively activate intracellular effectors, are currently being developed. Meanwhile, their effects on testicular steroidogenesis have not been studied. The purpose of this work is to perform a comparative study of the effects of 5-amino-N-tert-butyl-4-(3-(1-methylpyrazole-4-carboxamido)phenyl)-2-(methylthio)thieno[2,3-d] pyrimidine-6-carboxamide (TP4/2), a LHCGR allosteric agonist developed by us, and hCG on adenylyl cyclase activity in rat testicular membranes, testosterone levels, testicular steroidogenesis and spermatogenesis in young (four-month-old), aging (18-month-old) and diabetic male Wistar rats. Type 1 diabetes was caused by a single streptozotocin (50 mg/kg) injection. TP4/2 (20 mg/kg/day) and hCG (20 IU/rat/day) were administered for 5 days. TP4/2 was less effective in adenylyl cyclase stimulation and ability to activate steroidogenesis when administered once into rats. On the 3rd–5th day, TP4/2 and hCG steroidogenic effects in young adult, aging and diabetic rats were comparable. Unlike hCG, TP4/2 did not inhibit LHCGR gene expression and did not hyperstimulate the testicular steroidogenesis system, moderately increasing steroidogenic proteins gene expression and testosterone production. In aging and diabetic testes, TP4/2 improved spermatogenesis. Thus, during five-day administration, TP4/2 steadily stimulates testicular steroidogenesis, and can be used to prevent androgen deficiency in aging and diabetes.

Sign in / Sign up

Export Citation Format

Share Document