scholarly journals Lack of Effect of Calcium Intake on the 25-Hydroxyvitamin D Response to Oral Vitamin D3

2005 ◽  
Vol 90 (2) ◽  
pp. 707-711 ◽  
Author(s):  
Rula Goussous ◽  
Lingyi Song ◽  
Gerard E. Dallal ◽  
Bess Dawson-Hughes
Keyword(s):  
Vitamin D3 ◽  
Calcium Intake ◽  
Older Men ◽  
Control Group ◽  
Significant Group ◽  
Men And Women ◽  
Hydroxyvitamin D ◽  
Time Interaction ◽  
25 Hydroxyvitamin D ◽  
Older Men And Women

This study was conducted to examine the effect of calcium intake on the rise in serum 25-hydroxyvitamin D [25(OH)D] levels in response to supplemental vitamin D3. Fifty-two healthy older men and women were randomly assigned to take calcium (500 mg twice daily with meals) or placebo tablets for 90 d between October 1 and the end of March. All participants were placed on 800 IU/d (20 μg/d) vitamin D3. Serum 25(OH)D measurements were made at baseline and on d 30, 60, and 90. The mean baseline 25(OH)D values were 19.2 ± 6.4 ng/ml (47.9 ± 15.9 nmol/liter) in the calcium group and 19.6 ± 6.7 ng/ml (49.1 ± 16.7 nmol/liter) in the control group (P = 0.808). The difference in pattern of change in 25(OH)D was not statistically significant (group by time interaction, P = 0.651); the calcium group increased 6.5 ± 5.9 ng/ml (16.2 ± 14.8 nmol/liter; P < 0.001), and the control group increased 6.6 ± 7.0 ng/ml (16.6 ± 17.4 nmol/liter; P < 0.001). The 95% confidence interval for difference in mean increase, calcium vs. control, was −3.8 ± 3.5 ng/ml (−9.6, 8.7) nmol/liter. In older men and women, the level of calcium intake, within the range of 500-1500 mg/d, does not have an important effect on the rise in serum 25(OH)D that occurs in response to 800 IU (20 μg)/d vitamin D3.

scholarly journals Serum 25-Hydroxyvitamin D and the Onset of Late-Life Depressive Mood in Older Men and Women: The Pro.V.A. Study

2014 ◽  
Vol 69 (12) ◽  
pp. 1554-1561 ◽  
Author(s):  
E. D. Toffanello ◽  
G. Sergi ◽  
N. Veronese ◽  
E. Perissinotto ◽  
S. Zambon ◽  
...  
Keyword(s):  
Late Life ◽  
Older Men ◽  
Depressive Mood ◽  
Men And Women ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Older Men And Women

Serum 25-hydroxyvitamin d and the occurrence of late-life depressive mood in older men and women: The Pro.V.A Study

2013 ◽  
Vol 4 ◽  
pp. S49
Author(s):  
S. Sarti ◽  
E.D. Toffanello ◽  
G. Sergi ◽  
N. Veronese ◽  
E. Perissinotto ◽  
...  
Keyword(s):  
Late Life ◽  
Older Men ◽  
Depressive Mood ◽  
Men And Women ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Older Men And Women

25-Hydroxyvitamin D is not Associated with Carotid Intima-Media Thickness in Older Men and Women

2009 ◽  
Vol 84 (5) ◽  
pp. 423-424 ◽  
Author(s):  
Stefan Pilz ◽  
Ronald M. A. Henry ◽  
Marieke B. Snijder ◽  
Rob M. van Dam ◽  
Giel Nijpels ◽  
...  
Keyword(s):  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Older Men ◽  
Men And Women ◽  
Hydroxyvitamin D ◽  
Media Thickness ◽  
25 Hydroxyvitamin D ◽  
Older Men And Women

Effects of a 6-mo endurance-training program on venous compliance and maximal lower body negative pressure in older men and women

2005 ◽  
Vol 99 (3) ◽  
pp. 1070-1077 ◽  
Author(s):  
Juliane P. Hernandez ◽  
Warren D. Franke
Keyword(s):  
Training Program ◽  
Endurance Training ◽  
Lower Body Negative Pressure ◽  
Older Men ◽  
Exercise Group ◽  
Control Group ◽  
Lower Body ◽  
Venous Compliance ◽  
Men And Women ◽  
Older Men And Women

Aging and chronic exercise training influence leg venous compliance. Venous compliance affects responses to an orthostatic stress. The extent to which exercise training in a previously sedentary older population will affect venous compliance and tolerance to the simulated orthostatic stress of maximal lower body negative pressure (LBNP) is unknown. The purpose of this investigation is to determine the influence of a 6-mo endurance-training program on calf venous compliance and responses and tolerance to maximal LBNP in older men and women. Twenty participants (exercise group: n = 10, 5 men, 5 women; control group: n = 10, 6 men, 4 women; all >60 yr) underwent graded LBNP to presyncope or 4 min at −100 mmHg before and after a 6-mo endurance-training program. Utilizing venous occlusion plethysmography, calf venous compliance was determined in both groups using the first derivative of the pressure-volume relation during cuff pressure reduction before training, at 3 mo, and at the end of the training program. The exercise group improved their fitness with the 6-mo endurance-training program, whereas the control group did not change (14 ± 3 vs. <1 ± 2%; P < 0.05). LBNP tolerance did not differ between groups or across trials ( P = 0.47). Venous compliance was not different between groups or trials, either initially or after 3 mo of endurance training, but tended to be greater in the exercise group after 6 mo of training ( P = 0.08). These data suggest that a 6-mo endurance-training program may improve venous compliance without affecting tolerance to maximal LBNP in older participants.

Intra-trial mean 25(OH)D and PTH levels and risk of falling in older men and women in the Boston STOP IT trial

2022 ◽  
Author(s):  
Bess Dawson-Hughes ◽  
Jifan Wang ◽  
Kathryn Barger ◽  
Heike A Bischoff-Ferrari ◽  
Christopher T Sempos ◽  
...  
Keyword(s):  
Fall Risk ◽  
Minimal Risk ◽  
Risk Of Falling ◽  
Men And Women ◽  
Healthy Older Adults ◽  
Hydroxyvitamin D ◽  
Increase Risk ◽  
25 Hydroxyvitamin D ◽  
Independent Association ◽  
Older Men And Women

Abstract Context Supplementation with vitamin D has the potential to both reduce and increase risk of falling, and parathyroid hormone (PTH) may contribute to fall risk. Objective To assess the associations of intra-trial mean circulating levels of 25-hydroxyvitamin D [25(OH)D] and PTH on incident falls in healthy older adults. Design Observational within a clinical trial. Setting The Bone Metabolism Laboratory at the USDA Nutrition Center at Tufts University. Participants 410 men and women age 65 years and older who participated in the 3-year Boston STOP IT trial to determine the effect of supplementation with 700 IU of vitamin D3 plus calcium on incident falls (secondary endpoint). Intra-trial exposures of 25(OH)D and PTH were calculated as the mean of biannual measures up to and including the first fall. Main outcome measures: incidence of first fall Results Intra-trial mean 25(OH)D was significantly associated with risk of falling in a U-shaped pattern; the range associated with minimal risk of falling was approximately 20-40 ng/ml. PTH was not significantly associated with risk of falling. Conclusions The findings highlight the importance of maintaining the circulating 25(OH)D level between 20 and 40 ng/ml, the range that is also recommended for bone health. At PTH levels within the normal range, there was no detectible independent association of PTH with fall risk.

scholarly journals Effect of daily 2000 IU versus 800 IU vitamin D on blood pressure among adults age 60 years and older: a randomized clinical trial

2020 ◽  
Vol 112 (3) ◽  
pp. 527-537
Author(s):  
Lauren A Abderhalden ◽  
Sandra Meyer ◽  
Bess Dawson-Hughes ◽  
E John Orav ◽  
Ursina Meyer ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Vitamin D ◽  
Knee Osteoarthritis ◽  
Vitamin D3 ◽  
Vitamin D Supplementation ◽  
Control Group ◽  
High Dose ◽  
Hydroxyvitamin D ◽  
Daily Vitamin ◽  
25 Hydroxyvitamin D

ABSTRACT Background Observational studies report higher blood pressure (BP) among individuals with lower 25-hydroxyvitamin D concentration. Whether dosage of vitamin D supplementation has a differential effect on BP control remains unclear. Objective The study aimed to determine if daily vitamin D supplementation with 2000 IU is more effective than 800 IU for BP control among older adults. Methods This randomized, double-blind, ancillary trial of the Zurich Multiple Endpoint Vitamin D Trial in Knee Osteoarthritis enrolled adults aged ≥60 y who underwent elective surgery due to severe knee osteoarthritis. Participants were randomly assigned to receive high dose (2000 IU) or standard dose (800 IU) daily vitamin D3 for 24 mo. Outcomes included daytime and 24-h mean systolic BP. BP variability and serum 25-hydroxyvitamin D concentration were examined in a post hoc and observational analysis. Results Of the 273 participants randomly assigned, 250 participants completed a follow-up 24-h ambulatory BP monitoring (mean age: 70.4 ± 6.4 y; 47.2% men). The difference in daytime mean systolic BP reduction between the 2000 IU (n = 123) and 800 IU (n = 127) groups was not statistically significant (−2.75 mm Hg vs. −3.94 mm Hg; difference: 1.18 mm Hg; 95% CI: −0.68, 3.05; P = 0.21), consistent with 24-h mean systolic BP. However, systolic BP variability was significantly reduced with 2000 IU (average real variability: −0.37 mm Hg) compared to 800 IU vitamin D3 (0.11 mm Hg; difference: −0.48 mm Hg; 95% CI: −0.94, −0.01; P = 0.045). Independent of group allocation, maximal reductions in mean BP were observed at 28.7 ng/mL of achieved serum 25-hydroxyvitamin D concentrations. Conclusions While daily 2000 IU and 800 IU vitamin D3 reduced mean systolic BP over 2 y to a small and similar extent, 2000 IU reduced mean systolic BP variability significantly more compared with 800 IU. However, without a placebo control group we cannot ascertain whether vitamin D supplementation effectively reduces BP. This trial was registered at www.clinicaltrials.gov as NCT00599807.

scholarly journals Effects of Vitamin D Supplementation on Haematological Values and Muscle Recovery in Elite Male Traditional Rowers

Nutrients ◽  
2018 ◽  
Vol 10 (12) ◽  
pp. 1968 ◽  
Author(s):  
Juan Mielgo-Ayuso ◽  
Julio Calleja-González ◽  
Aritz Urdampilleta ◽  
Patxi León-Guereño ◽  
Alfredo Córdova ◽  
...  
Keyword(s):  
Vitamin D ◽  
Body Mass ◽  
Iron Metabolism ◽  
Vitamin D3 ◽  
Repeated Measures ◽  
Vitamin D Supplementation ◽  
Control Group ◽  
Muscle Recovery ◽  
Hydroxyvitamin D ◽  
Time Interaction

Introduction: Deficient levels of 25-hydroxyvitamin D (25(OH)D) (<30 ng/mL) may compromise health and athletic performance. Supplementation with oral vitamin D can favor the state of iron metabolism, and testosterone and cortisol as an indicator of muscle recovery of the athlete with a deficiency. The main aim of this study was to evaluate the influence of eight weeks of supplementation with 3000 IU/day of vitamin D on the hematological and iron metabolism profile, as well as on the analytical values of testosterone and cortisol on elite male traditional rowers. The secondary aim was to examine if serum 25(OH)D is a predictor of testosterone and cortisol levels. Material and Methods: Thirty-six elite male rowers (27 ± 6 years) were assigned to one of the two groups randomly: 1) Control group (CG, n = 18, height: 181.05 ± 3.39 cm and body mass: 77.02 ± 7.55 kg), 2) Group treated with 3,000 IU of vitamin D3/day (VD3G, s = 18, height: 179.70 ± 9.07 cm and body mass: 76.19 ± 10.07 kg). The rowers were subjected to blood tests at the beginning of the study (T1) and after eight weeks of treatment (T2), for the analysis of hematological and hormonal values. Repeated-measures ANOVA with group factor (GC and GVD3) were used to examine if the interaction of the different values was the same or different between the groups throughout the study (time × group) after vitamin D3 treatment. To analyze if 25(OH)D was a good predictor of testosterone, cortisol, and testosterone/cortisol ratio a stepwise regression model was performed. Results: Statistically significant and different increases were observed in the group-by-time interaction of 25(OH)D in VD3G in respect to CG during the study (p < 0.001; VD3G (T1: 26.24 ± 8.18 ng/mL vs. T2: 48.12 ± 10.88 ng/mL) vs CG (T1: 30.76 ± 6.95 ng/mL vs. T2: 35.14 ± 7.96 ng/mL). Likewise, significant differences between groups were observed throughout the study in the group-by-time interaction and changes of hemoglobin (GC: −2.89 ± 2.29% vs. VD3G: 0.71 ± 1.91%; p = 0.009), hematocrit (CG: −1.57 ± 2.49% vs. VD3G: 1.16 ± 1.81%; p = 0.019) and transferrin (CG: 0.67 ± 4.88% vs. VD3G: 6.51 ± 4.36%; p = 0.007). However, no differences between groups were observed in the group-by-time interaction of the hormonal parameters (p > 0.05). Regression multivariate analysis showed that cortisol and testosterone levels were associated with 25(OH)D levels (p < 0.05). Conclusion: Oral supplementation with 3000 IU/day of vitamin D3 during eight weeks showed to be sufficient to prevent a decline in hematological levels of hemoglobin and hematocrit, and improve transferrin of 25(OH)D levels. However, although it was not sufficient to enhance muscle recovery observed by testosterone and cortisol responses, it was observed that serum 25(OH)D levels could be a predictor of anabolic and catabolic hormones.

The Case of Thematic Tests Adapted to Older Adults

2011 ◽  
Vol 32 (1) ◽  
pp. 46-71 ◽  
Author(s):  
Benoît Verdon
Keyword(s):  
Older Adults ◽  
Older Persons ◽  
Older Men ◽  
Elderly Persons ◽  
Mental Processes ◽  
Men And Women ◽  
Projective Tests ◽  
New Material ◽  
Older Men And Women ◽  
Latent Content

Since the 1950s, the growing interest of clinicians in using projective tests to study normal or pathological aging processes has led to the creation of several thematic tests for older adults. This development reflects their authors’ belief that the TAT is not suitable to the concerns and anxieties of elderly persons. The new material thus refers explicitly to situations related to age; it aims to enable older persons to express needs they cannot verbalize during consultations. The psychodynamic approach to thematic testing is based on the differentiation between the pictures’ manifest and latent content, eliciting responses linked to mental processes and issues the respondent is unaware of. The cards do not necessarily have to show aging characters to elicit identification: The situations shown in the pictures are linked to loss, rivalry, helplessness, and renunciation, all issues elderly respondents can identify with and that lead them to express their mental fragilities and resources. The article first explains the principles underlying four of these thematic tests, then develops several examples of stories told for card 3BM of the TAT, thus showing the effectiveness of this tool for the understanding and differentiation of loss-related issues facing older men and women.

Sign in / Sign up

Export Citation Format

Share Document