scholarly journals Positron Emission Tomography Reveals Correlations between Brain Metabolism and Mood Changes in Hyperthyroidism

2006 ◽  
Vol 91 (12) ◽  
pp. 4786-4791 ◽  
Author(s):  
M. F. Schreckenberger ◽  
U. T. Egle ◽  
S. Drecker ◽  
H. G. Buchholz ◽  
M. M. Weber ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Brain Metabolism ◽  
Emission Tomography ◽  
Mood Changes ◽  
Positron Emission

Positron emission tomography (PET) study on the neuronal correlates of hyperthyroidism- associated mood changes

2005 ◽  
Vol 113 (S 1) ◽  
Author(s):  
GJ Kahaly ◽  
UT Egle ◽  
P Bartenstein ◽  
M Dittmar ◽  
S Drecker ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Emission Tomography ◽  
Mood Changes ◽  
Positron Emission

Neural correlates of hot and cold executive functions in polysubstance addiction: Association between neuropsychological performance and resting brain metabolism as measured by positron emission tomography

2012 ◽  
Vol 203 (2-3) ◽  
pp. 214-221 ◽  
Author(s):  
Laura Moreno-López ◽  
Emmanuel Andreas Stamatakis ◽  
María José Fernández-Serrano ◽  
Manuel Gómez-Río ◽  
Antonio Rodríguez-Fernández ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Executive Functions ◽  
Brain Metabolism ◽  
Neural Correlates ◽  
Emission Tomography ◽  
Neuropsychological Performance ◽  
Positron Emission

29 POSITRON EMISSION TOMOGRAPHY IMAGING OF BRAIN METABOLISM AND DOPAMINERGIC NEURON DESTRUCTION IN PARKINSON'S DISEASE MODEL PIG

2017 ◽  
Vol 29 (1) ◽  
pp. 122
Author(s):  
H. J. Oh ◽  
J. Moon ◽  
G. A. Kim ◽  
S. Lee ◽  
S. H. Paek ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Dopaminergic Neuron ◽  
Brain Metabolism ◽  
Brain Research ◽  
Brain Regions ◽  
Emission Tomography ◽  
Positron Emission ◽  
Significant Difference ◽  
And Control ◽  
The Brain

Due to similarities between human and porcine, pigs have been proposed as an excellent experimental animal for human medical research. Especially in paediatric brain research, piglets share similarities with human infants in the extent of peak brain growth at the time of birth and the growth pattern of brain. Thus, these findings have supported the wider use of pigs rather than rodents in neuroscience research. Previously, we reported the production of porcine model of Parkinson's disease (PD) by nuclear transfer using donor cell that had been stably infected with lentivirus containing the human α-synuclein gene. The purpose of this study was to determine the alternation of brain metabolism and dopaminergic neuron destruction using noninvasive method in a 2-yr-old PD model and a control pig. The positron emission tomography (PET) scan was done using Biograph TruePoint40 with a TrueV (Siemens, Munich, Germany). The [18F]N-(3-fluoropropyl)-2β-carbomethoxy-3β-(4-iodophenyl) nortropane (FP-CIT) was administrated via the ear vein. Static images of the brain for 15 min were acquired from 2 h after injection. The 18F-fluorodeoxy-D-glucose PET (18F-FDG PET) images of the brain were obtained for 15 min at 45 min post-injection. Computed tomography (CT) scan and magnetic resonance imaging (MRI) were performed at the same location of the brain. In both MRI and CT images, there was no difference in brain regions between PD model and control pigs. However, administration of [18F]FP-CIT was markedly decreased in the bilateral putamen of the PD model pig compared with the control pigs. Moreover, [18F]FP-CIT administration was asymmetrical in the PD model pig but it was symmetrical in control pigs. Regional brain metabolism was also assessed and there was no significant difference in cortical metabolism of PD model and control pigs. We demonstrated that PET imaging could provide a foundation for translational Parkinson neuroimaging in transgenic pigs. In the present study, a 2-yr-old PD model pig showed dopaminergic neuron destruction in brain regions. Therefore, PD model pig expressing human α-synuclein gene would be an efficient model for human PD patients. This study was supported by Korea IPET (#311011–05–5-SB010), Research Institute for Veterinary Science, TS Corporation and the BK21 plus program.

Cerebral Brain Metabolism in Adult Dyslexic Subjects Assessed With Positron Emission Tomography During Performance of an Auditory Task

1992 ◽  
Vol 49 (7) ◽  
pp. 734-739 ◽  
Author(s):  
J. O. Hagman ◽  
F. Wood ◽  
M. S. Buchsbaum ◽  
P. Tallal ◽  
L. Flowers ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Brain Metabolism ◽  
Emission Tomography ◽  
Auditory Task ◽  
Positron Emission

scholarly journals A 18F-fluorodeoxyglucose MicroPET Imaging Study to Assess Changes in Brain Glucose Metabolism in a Rat Model of Surgery-induced Latent Pain Sensitization

2011 ◽  
Vol 115 (5) ◽  
pp. 1072-1083 ◽  
Author(s):  
Asunción Romero ◽  
Santiago Rojas ◽  
David Cabañero ◽  
Juan D. Gispert ◽  
José R. Herance ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Rat Model ◽  
Brain Metabolism ◽  
Statistical Parametric Mapping ◽  
Imaging Study ◽  
Emission Tomography ◽  
Posterior Cortex ◽  
Fdg Uptake ◽  
Positron Emission ◽  
Pain Sensitization

Background Neuroplastic changes involved in latent pain sensitization after surgery are poorly defined. We assessed temporal changes in glucose brain metabolism in a postoperative rat model using positron emission tomography. We also investigated brain metabolism after naloxone administration. Methods Rats were given remifentanil anesthetic and underwent a plantar incision, with 1 mg/kg of (-)-naloxone subcutaneously administered on postoperative days 20 and 21. Using the von Frey test, mechanical thresholds were measured pre- and postoperatively at different time points in awake animals during F-fluorodeoxyglucose (F-FDG) uptake. Brain images were also obtained the day before mechanical testing, using a positron emission tomography R4 scanner (Concorde Microsystems, Siemens, Knoxville, TN). Differences in brain activity were assessed utilizing a statistical parametric mapping. Results Surgery induced minor changes in F-FDG uptake in the cerebellum, hippocampus, and posterior cortex, which extended to the thalamus, hypothalamus, and brainstem on days 6 and 7. Changes were still present on day 21. Maximal postoperative hypersensitivity was observed on day 2. The administration of (-)-naloxone on day 21 induced significant hypersensitivity, greatly enhancing the effect on F-FDG uptake. In sham-operated rats, naloxone induced changes limited to the striatum and the cerebellum. Nonnociceptive stimulation with von Frey filaments had no effect on F-FDG uptake. Conclusions Surgery, remifentanil, and their combination induced long-lasting and significant metabolic changes in the pain brain matrix, with a positive correlation with hypersensitivity after naloxone. Changes in brain F-FDG precipitated by naloxone suggest that surgery under remifentanil anesthetic induces the greatest neuroplastic brain adaptations in opioid-related pathways involved in nociceptive processing and long-lasting pain sensitization.

Biological Basis of Emotions: Brain Systems and Brain Development

PEDIATRICS ◽  
1998 ◽  
Vol 102 (Supplement_E1) ◽  
pp. 1225-1229
Author(s):  
Harry T. Chugani
Keyword(s):  
Positron Emission Tomography ◽  
Brain Development ◽  
Emotional Development ◽  
Critical Period ◽  
Brain Metabolism ◽  
Functional Neuroimaging ◽  
Emission Tomography ◽  
Biological Basis ◽  
Positron Emission ◽  
Neuroimaging Techniques

Functional neuroimaging techniques such as positron emission tomography have made it possible to investigate brain metabolism noninvasively during development. Studies have revealed a dynamic period of metabolic maturation and neuronal growth corresponding to the processes of synaptic proliferation and pruning of unused pathways. This physiologic plasticity is believed to be the biological basis for a critical period of learning and emotional development.

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