scholarly journals Skeletal Muscle Mass in Acromegaly Assessed by Magnetic Resonance Imaging and Dual-Photon X-Ray Absorptiometry

2009 ◽  
Vol 94 (8) ◽  
pp. 2880-2886 ◽  
Author(s):  
Pamela U. Freda ◽  
Wei Shen ◽  
Carlos M. Reyes-Vidal ◽  
Eliza B. Geer ◽  
Fernando Arias-Mendoza ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Skeletal Muscle ◽  
Whole Body ◽  
Resonance Imaging ◽  
Lean Tissue ◽  
Tissue Mass ◽  
Lean Tissue Mass ◽  
X Ray ◽  
Igf I ◽  
Active Acromegaly

Context: GH and IGF-I are nitrogen retaining and anabolic, but the impact of long-term exposure to supraphysiological GH and IGF-I, either from endogenous overproduction in acromegaly or exogenous sources, on skeletal muscle (SM) mass is not clear. Objectives: The objectives of the study were to assess SM mass by whole-body magnetic resonance imaging (MRI) in acromegaly and test the hypothesis that dual-energy x-ray absorptiometry (DXA) lean tissue mass-derived estimates of SM accurately estimate true SM mass. Design, Setting, and Patients: The design was a cross-sectional study in 27 acromegaly patients compared with predicted models developed in 315 nonacromegaly subjects and to matched controls. Outcome Measures: Mass of SM from whole-body MRI and lean tissue from DXA were measured. Results: SM mass did not differ from predicted or control values in active acromegaly: 31.75 ± 8.6 kg (acromegaly) vs. 33.06 ± 8.9 kg (predicted); SM was 95.6 ± 12.8% of predicted (range 66.7–122%) (P = 0.088). Lean tissue mass (DXA) was higher in acromegaly than controls: 65.91 ± 15.2 vs. 58.73 ± 13.5 kg (P < 0.0001). The difference between lean tissue mass (DXA) and SM in acromegaly patients was higher than that in controls (P < 0.0001) consistent with an enlarged non-SM lean compartment in acromegaly. SM mass predicted by DXA correlated highly with SM mass by MRI (r = 0.97, P < 0.0001). SM (MRI) to SM (DXA predicted) ratio was 1.018 (range 0.896–1.159), indicating high agreement of these measures of SM. Conclusions: SM mass in active acromegaly patients did not differ from predicted values. SM mass estimated from DXA agreed highly with SM by MRI, supporting the validity of the DXA model in assessing SM in acromegaly and other disorders of GH/IGF-I secretion.

scholarly journals Relationship between Dual-Energy X-Ray Absorptiometry-Derived Appendicular Lean Tissue Mass and Total Body Skeletal Muscle Mass Estimated by Ultrasound

2013 ◽  
Vol 04 (06) ◽  
pp. 283-286 ◽  
Author(s):  
Takashi Abe ◽  
Nicole C. Dabbs ◽  
Vinayak K. Nahar ◽  
M. Allison Ford ◽  
Martha A. Bass ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Mass ◽  
Skeletal Muscle Mass ◽  
Dual Energy ◽  
Lean Tissue ◽  
Tissue Mass ◽  
Lean Tissue Mass ◽  
X Ray ◽  
Total Body

Whole-Body Magnetic Resonance Imaging in Skeletal Muscle Disease

2010 ◽  
Vol 14 (01) ◽  
pp. 047-056 ◽  
Author(s):  
Martin Shelly ◽  
Ferdia Bolster ◽  
Paul Foran ◽  
Ian Crosbie ◽  
Eoin Kavanagh ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Skeletal Muscle ◽  
Magnetic Resonance ◽  
Muscle Disease ◽  
Whole Body ◽  
Resonance Imaging ◽  
Body Magnetic Resonance Imaging

scholarly journals Effects of octreotide on sleep apnoea and tongue volume (magnetic resonance imaging) in patients with acromegaly

2004 ◽  
pp. 309-315 ◽  
Author(s):  
BL Herrmann ◽  
TE Wessendorf ◽  
W Ajaj ◽  
S Kahlke ◽  
H Teschler ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Obstructive Sleep Apnoea ◽  
Signal Intensity ◽  
Sleep Apnoea ◽  
Resonance Imaging ◽  
Obstructive Sleep ◽  
Igf I ◽  
Active Acromegaly ◽  
Tongue Volume

OBJECTIVES: Sleep apnoea has been consistently reported to occur in acromegaly. Both obstructive apnoeas, in which apnoeas are due to intermittent obstruction of the upper airways, as well as central apnoeas are known to occur. Because the relationship between disease activity and severity of sleep apnoea is currently unclear, we have performed a prospective study to address this issue. DESIGN AND METHODS: In 14 newly diagnosed patients with active acromegaly (eight females and six males; mean age 57+/-4 years; IGF-I 583+/-48 microg/l; GH 13.5+/-7.0 microg/l (means+/-s.e.m.)), tongue volume and signal intensity of the tongue were examined by magnetic resonance imaging and sleep apnoea was characterised by polysomnography before and after 6 months of treatment with octreotide acetate (Sandostatin LAR 10-30 mg every 4 weeks i.m.). RESULTS: The initial tongue volume was significantly higher in patients with acromegaly (151+/-9 ml; females 133+/-10 ml; males 172+/-10 ml) in comparison with the body mass index (BMI)- and age-matched healthy control group (97+/-5 ml, P<0.001; females 75+/-1 ml, P<0.001; males 120+/-3 ml, P<0.003). After treatment with octreotide, IGF-I was normalised within the age-adjusted normal range in 50% of the patients. In these patients, tongue volume significantly decreased (120+/-14 ml, P<0.05) in comparison with the persistent uncontrolled group of acromegalics (137+/-10 ml, P=not significant). Overall, tongue volume (128+/-8 ml, P<0.05) and the signal intensity ratio of the tongue decreased significantly after treatment with octreotide acetate (120+/-3 vs 105+/-3, P=0.003). The BMI-adjusted tongue volume correlated with IGF-I levels (r=0.60, P<0.002) and the disease duration (r=0.71, P=0.006). At baseline, 50% had obstructive sleep apnoea with a mean respiratory disturbance index (RDI) of >20/h (range 5.1-91.5) and no patient had central sleep apnoea. After 6 months of octreotide treatment, there was a 28+/-10% decrease in RDI. However, RDI did not correlate with IGF-I or GH levels, but correlated positively with BMI (r=0.58, P=0.001) and age (r=0.46, P=0.02). CONCLUSIONS: Obstructive sleep apnoea but not central sleep apnoea frequently occurs in patients with active acromegaly. Successful treatment with octreotide can decrease tongue volume, which may have benefits for coexisting sleep-disordered breathing.

High-resolution magnetic resonance imaging tracks changes in organ and tissue mass in obese and aging rats

2002 ◽  
Vol 282 (3) ◽  
pp. R890-R899 ◽  
Author(s):  
Haiying Tang ◽  
Joseph R. Vasselli ◽  
Ed X. Wu ◽  
Carol N. Boozer ◽  
Dympna Gallagher
Keyword(s):  
Magnetic Resonance Imaging ◽  
Adipose Tissue ◽  
Magnetic Resonance ◽  
High Resolution ◽  
Soft Tissues ◽  
Whole Body ◽  
Resonance Imaging ◽  
Sprague Dawley ◽  
Tissue Mass

Magnetic resonance imaging (MRI) has the ability to discriminate between various soft tissues in vivo. Whole body, specific organ, total adipose tissue (TAT), intra-abdominal adipose tissue (IAAT), and skeletal muscle (SM) weights determined by MRI were compared with weights determined by dissection and chemical analysis in two studies with male Sprague-Dawley rats. A 4.2-T MRI machine acquired high-resolution, in vivo, longitudinal whole body images of rats as they developed obesity or aged. Weights of the whole body and specific tissues were determined using computer image analysis software, including semiautomatic segmentation algorithms for volume calculations. High correlations were found for body weight ( r = 0.98), TAT ( r = 0.99), and IAAT ( r = 0.98) between MRI and dissection and chemical analyses. MRI estimated the weight of the brain, kidneys, and spleen with high accuracy ( r > 0.9), but overestimated IAAT, SM, and liver volumes. No differences were detected in organ weights using MRI and dissection measurements. Longitudinal MRI measurements made during the development of obesity and aging accurately represented changes in organ and tissue mass.

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