Association of Intact Parathyroid Hormone Levels with Subsequent Hip BMD Loss: The Osteoporotic Fractures in Men (MrOS) Study

Introduction: There is little information on the association between intact PTH (iPTH) and longitudinal changes in bone mineral density (BMD) in older men. This association was evaluated in relation to conditions related to higher iPTH [e.g. decreased renal function, low serum 25-hydroxyvitamin D (25[OH]D)]. Methods: Eligible men were part of a random sample of 1593 community-dwelling individuals aged 65 yr or older participating in the Osteoporotic Fractures in Men study with baseline iPTH data. Of these, 1227 had at least two BMD measurements at the total hip and femoral neck over a mean follow-up of 4.5 yr. Annualized BMD change across iPTH quartiles was estimated using mixed-effects regression models, adjusting for age, serum calcium, serum 25(OH)D, estimated glomerular filtration rate, and other factors. Splines were used to identify more optimal iPTH thresholds associated with less BMD loss. Results: Among the cohort of 1138 eligible men, men in the highest quartile of iPTH (≥38 pg/ml) lost 0.46% per year at the total hip compared with men in the lowest iPTH quartile who lost 0.22% per year (P = 0.0004). Results were similar at the femoral neck. The association between iPTH and BMD loss was not modified by baseline estimated glomerular filtration rate or 25(OH)D status. Spline results suggested that iPTH levels below 30 pg/ml were more physiologically optimal than higher iPTH values in reducing BMD loss, although an exact threshold for optimal iPTH was not identified. Conclusion: Older men with higher iPTH levels had approximately a 2-fold greater rate of BMD loss compared with men with lower iPTH levels, irrespective of estimated glomerular filtration rate and 25(OH)D.

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Effects of Estimated Glomerular Filtration Rate on 30-Day Mortality and Postoperative Complications After Total Hip Arthroplasty: A Risk Stratification Instrument

The Journal of Arthroplasty ◽

10.1016/j.arth.2019.10.001 ◽

2020 ◽

Vol 35 (3) ◽

pp. 786-793

Author(s):

Jared A. Warren ◽

Jaiben George ◽

Hiba K. Anis ◽

Olivia K. Krebs ◽

Robert M. Molloy ◽

...

Keyword(s):

Glomerular Filtration Rate ◽

Postoperative Complications ◽

Total Hip Arthroplasty ◽

Risk Stratification ◽

Glomerular Filtration ◽

Hip Arthroplasty ◽

Filtration Rate ◽

Estimated Glomerular Filtration Rate ◽

Total Hip

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Association of Kidney Function Tests with a Cardio-Ankle Vascular Index in Community-Dwelling Individuals with a Normal or Mildly Decreased Estimated Glomerular Filtration Rate

Medicina ◽

10.3390/medicina55100657 ◽

2019 ◽

Vol 55 (10) ◽

pp. 657 ◽

Cited By ~ 1

Author(s):

Javad Alizargar ◽

Chyi-Huey Bai ◽

Nan-Chen Hsieh ◽

Shu-Fang Vivienne Wu ◽

Shih-Yen Weng ◽

...

Keyword(s):

Risk Factors ◽

Risk Factor ◽

Glomerular Filtration Rate ◽

Arterial Stiffness ◽

Glomerular Filtration ◽

Filtration Rate ◽

Estimated Glomerular Filtration Rate ◽

Community Dwelling ◽

Atherosclerosis Risk ◽

Atherosclerosis Risk Factors

Background and objectives: Chronic kidney disease (CKD) is an independent risk factor for cardiovascular disease (CVD). Previous studies reported controversial results about the independence of CKD as a risk factor for atherosclerosis. In this study, we tried to determine whether the estimated glomerular filtration rate (eGFR) and other renal function tests are independent factors associated with arterial stiffness in community-dwelling individuals with a normal (≥90) or slightly decreased eGFR (60-90). Materials and Methods: Data of 164 community individuals were analyzed, and demographic information, related disease history, atherosclerosis risk factors, certain laboratory tests, the estimated eGFR, and urine albumin creatinine ratio (UACR) were recorded for each individual. Results: The age, systolic blood pressure (SBP), hypertension (HTN), and cardio-ankle vascular index (CAVI) significantly differed between individuals with a normal and those with a slightly decreased eGFR. Blood urea nitrogen (BUN), glycated hemoglobin (HBA1c), and the eGFR significantly differed between the high- and low-CAVI groups and were also significantly correlated with the CAVI. The relationship between the eGFR and CAVI was shown to be independent of other atherosclerosis risk factors in a multiple linear regression model. Conclusions: We concluded that evaluations of the eGFR, HTN, body-mass index, and SBP can be used in a model for arterial stiffness risk assessments for community-dwelling individuals with a normal or slightly decreased eGFR.

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