scholarly journals Effects of Early Thyroxine Treatment on Development and Growth at Age 10.7 Years: Follow-Up of a Randomized Placebo-Controlled Trial in Children With Down's Syndrome

2014 ◽  
Vol 99 (12) ◽  
pp. E2722-E2729 ◽  
Author(s):  
Jan Pieter Marchal ◽  
Heleen Maurice-Stam ◽  
Nadine A. Ikelaar ◽  
Femke C. C. Klouwer ◽  
Kim W. J. Verhorstert ◽  
...  
Keyword(s):  
Controlled Trial ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Thyroxine Treatment

Comparison of Two Scales for Assessing Motor Development in Infants with down's Syndrome

1983 ◽  
Vol 3 (4) ◽  
pp. 213-221 ◽  
Author(s):  
Joan Snyder Lydic ◽  
Margaret A. Short ◽  
David L. Nelson
Keyword(s):  
Motor Development ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Motor Ability ◽  
Before And After ◽  
Partial Correlations ◽  
Depth Study ◽  
Movement Assessment ◽  
Stability Results

The Peabody Developmental Scales (PDS) and the Movement Assessment of Infants (MAI) were examined for their abilities to detect subtle changes in motor development of infants with Down's syndrome Both assessments were administered to 10 infants before and after a 6-week period A t-test suggested that the MAI was sensitive to developmental changes in the subjects tested from initial test to follow-up. Similar testing using the PDS did not reveal significant differences in the scores, suggesting that the MAI was the more sensitive of the two instruments. When partial correlations were calculated for possible artifactual effects due to age, the MAI still demonstrated greater stability. Results indicate that, for infants with Down's syndrome, the MAI may be preferable to the PDS for detecting changes in motor ability over short periods. However, these results should be considered tentative until a more in-depth study is conducted using a larger number of subjects from a variety of clinical populations.

scholarly journals Diet quality and well-being in children and adolescents: the UP&DOWN longitudinal study

2018 ◽  
Vol 121 (2) ◽  
pp. 221-231 ◽  
Author(s):  
Laura Esteban-Gonzalo ◽  
Anne I. Turner ◽  
Susan J. Torres ◽  
Irene Esteban-Cornejo ◽  
José Castro-Piñero ◽  
...  
Keyword(s):  
Secondary School ◽  
Negative Affect ◽  
Primary School ◽  
Positive Affect ◽  
Children And Adolescents ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Well Being ◽  
School Girls

AbstractThe present study examined the association between high-quality diet (using the Mediterranean diet (MD) as an example) and well-being cross-sectionally and prospectively in Spanish children and adolescents. Participants included 533 children and 987 adolescents at baseline and 527 children and 798 adolescents at 2-year follow-up, included in the UP&DOWN study (follow-up in schoolchildren and adolescents with and without Down’s syndrome). The present study excluded participants with Down’s syndrome. Adherence to an MD was assessed using the KIDMED index. Well-being was measured using the Positive and Negative Affect Schedule and the KIDSCREEN-10 questionnaire. Associations between MD adherence and well-being were assessed using multi-level, mixed-effects linear regression. At baseline, MD adherence was positively related to health-related quality of life in secondary school girls and boys (β=0·41,se0·10,P<0·001;β=0·46,se0·10,P<0·001, respectively) and to positive affect in secondary school girls and boys (β=0·16,se0·05,P=0·006;β=0·20,se0·05,P<0·001, respectively) and in primary school boys (β=0·20,se0·08,P=0·019). At 2-year follow-up, MD adherence was negatively related to negative affect in secondary school adolescent girls and boys (β=–0·15,se0·07,P=0·047;β=–0·16,se0·06,P=0·019, respectively), and MD adherence was associated with higher positive affect scores in secondary school girls (β=0·30,se0·06,P<0·001) and in primary school boys (β=0·20,se0·09,P=0·023). However, MD adherence at baseline did not predict well-being indicators at 2-year follow-up. In conclusion, higher MD adherence was found to behave as a protective factor for positive well-being in cross-sectional analysis.

A five year follow-up study of dementia in persons with Down's syndrome: early symptoms and patterns of deterioration

2000 ◽  
Vol 17 (1) ◽  
pp. 5-11 ◽  
Author(s):  
Mary P Cosgrave ◽  
Janette Tyrrell ◽  
Mary McCarron ◽  
Michael Gill ◽  
Brian A Lawlor
Keyword(s):  
Clinical Features ◽  
Rating Scales ◽  
Age At Onset ◽  
Down's Syndrome ◽  
Memory Loss ◽  
Down’S Syndrome ◽  
Personal Hygiene ◽  
Follow Up Study ◽  
Diagnosis Of Dementia

AbstractObjectives: To investigate the development of dementia over a five year follow up period in a population of females with Down's syndrome; to examine age at onset and duration of dementia in the population; to document the clinical features of dementia and to highlight scores on functional and cognitive rating scales at diagnosis of dementia and at the onset of complete dependency.Method: A five year follow-up study of 80 female subjects on prevalence of dementia, early clinical features of dementia and patterns of scoring on rating scales at diagnosis and end-stage dementia was completed. Results: Over the five year study period the number of subjects diagnosed with dementia rose from seven (8.75%) to 35 (43.75%). Age related prevalence figures showed that dementia was more common with increasing age. The earliest recognisable symptoms of dementia were memory loss, spatial disorientation and loss of independence especially in the area of personal hygiene. These findings were confirmed by the rating scales used in the study.Conclusions: The earliest recognisable clinical features of dementia include memory loss and increased dependency. The results of this study should facilitate earlier diagnosis of dementia in DS.

Down's Syndrome and Eating Disorders

1988 ◽  
Vol 152 (6) ◽  
pp. 847-848 ◽  
Author(s):  
G. M. Holt ◽  
N. Bouras ◽  
J. P. Watson
Keyword(s):  
Eating Disorders ◽  
Anorexia Nervosa ◽  
Clinical Symptoms ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Patient Treatment

We describe the case of a 33-year-old man with Down's syndrome and severe eating disorders. The clinical symptoms, and their difference from those of anorexia nervosa, are discussed. The patient responded well to a strict behavioural programme after long, in-patient treatment and was still well at a 2-year follow-up examination.

Immunodeficiency and plasma zinc levels in children with Down's syndrome: A long-term follow-up of oral zinc supplementation

1991 ◽  
Vol 58 (2) ◽  
pp. 207-216 ◽  
Author(s):  
A. Stabile ◽  
M.A. Pesaresi ◽  
A.M. Stabile ◽  
M. Pastore ◽  
S.Miceli Sopo ◽  
...  
Keyword(s):  
Zinc Supplementation ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Plasma Zinc ◽  
Long Term Follow Up ◽  
Zinc Levels

scholarly journals Children with Down's Syndrome in Lancaster, Kendal and South Lakes

2004 ◽  
Vol 4 (9) ◽  
pp. 256-257
Author(s):  
Sue Brown ◽  
Ram Gobburu
Keyword(s):  
At Risk ◽  
Interest Group ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Clinic Visit ◽  
Medical Review ◽  
Community Clinics ◽  
Medical Interest

Children with Down's syndrome are mainly well, with their main needs being educational and social, but they are at risk of certain conditions and do warrant regular medical review. In light of recommendations from the Down's syndrome  Medical Interest Group on medical follow-up of children with Down's syndrome, a form was designed for use in community clinics to act as an aide memoire (see appendix). Versions of this form are now being used in Lancaster, Kendal and South Lakes. To aid audit, it is updated at the annual clinic visit and is photocopied to the office at Langlands, where the data are entered onto a spreadsheet database in Excel.  

Fifteen-minute consultation: The review of a child with trisomy 21 (Down’s syndrome)

2021 ◽  
pp. edpract-2020-319814 ◽  
Author(s):  
Rebecca Amy Dalrymple ◽  
Laura Helen Somerville ◽  
Sherin Hamza ◽  
Nashwa Matta
Keyword(s):  
Intellectual Disability ◽  
Chromosomal Abnormality ◽  
Trisomy 21 ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Many Body ◽  
Life Threatening ◽  
Many Body Systems

Down’s syndrome (DS) is the most common chromosomal abnormality seen in live born children and it is the most common genetic cause of intellectual disability. It is associated with abnormalities in many body systems, some of which can cause life threatening complications. This article aims to cover the important aspects to cover when seeing children with DS for their routine follow-up in the neurodevelopmental or general paediatric clinic.

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