Expression of inhibin/activin system messenger ribonucleic acids and proteins in ovarian follicles from women with polycystic ovarian syndrome

1994 ◽  
Vol 79 (5) ◽  
pp. 1434-1439 ◽  
Author(s):  
V. J. Roberts
Keyword(s):  
Polycystic Ovarian Syndrome ◽  
Ovarian Follicles ◽  
Ribonucleic Acids ◽  
Ovarian Syndrome

Expression of inhibin α,βA and βB messenger ribonucleic acids in the normal human ovary and in polycystic ovarian syndrome

1994 ◽  
Vol 143 (1) ◽  
pp. 127-137 ◽  
Author(s):  
T-A Jaatinen ◽  
T-L Penttilä ◽  
A Kaipia ◽  
T Ekfors ◽  
M Parvinen ◽  
...  
Keyword(s):  
Granulosa Cells ◽  
Cellular Localization ◽  
Polycystic Ovarian Syndrome ◽  
Human Ovary ◽  
Α Subunit ◽  
Ribonucleic Acids ◽  
Theca Cells ◽  
Subunit Mrna ◽  
Normal Human ◽  
Ovarian Syndrome

Abstract We studied the cellular distribution of inhibin α, βA and βB mRNAs in the normal human ovary and in polycystic ovarian syndrome (PCOS) by in situ hybridization. Our results show that human granulosa cells express inhibin α, βA and βB subunit mRNAs, and theca cells express inhibin α and βA subunit mRNAs. The co-localization of α and βA mRNAs in theca cells supports the hypothesis that inhibin also has an autocrine function in these cells. We did not detect any inhibin subunit mRNA in the granulosa cells of atretic follicles, while theca cells also expressed α subunit mRNA in those follicles. The present findings suggest that the expression of inhibin subunits is regulated differently in human follicular granulosa and theca cells. It has been speculated that inhibin may be involved in the development of PCOS. Our results show that the cellular localization of inhibin subunit mRNAs is not disturbed in PCOS ovaries. Journal of Endocrinology (1994) 143, 127–137

scholarly journals Effects of Ferula assa-foetida on clinical, hormonal and ultrasound parameters in young girls with polycystic ovary syndrome: a randomized, placebo controlled, triple-blinded

2020 ◽  
Author(s):  
Fatemeh Ghavi ◽  
somayeh abdolahian ◽  
Fatemeh Shakeri ◽  
Mahboubeh Taebi
Keyword(s):  
Clinical Trial ◽  
Polycystic Ovarian Syndrome ◽  
Endometrial Thickness ◽  
Intervention Group ◽  
Ovarian Follicles ◽  
Control Group ◽  
Controlled Clinical Trial ◽  
P Value ◽  
Young Girls ◽  
Ovarian Syndrome

Abstract Background: Polycystic ovarian syndrome is the most common endocrine disorder in reproductive aged women. As a result of side effect of pharmaceutical medications women are interested in using alternative medicines to treat. To determine the comparative effects of Ferula assa-foetida on androgenic hormone levels and ovarian features in patient with polycystic ovarian syndrome (PCOS). Methods: In this triple-blinded controlled clinical trial, 34 student participants were randomly divided in two groups. Intervention group received 100 mg of oleo-gum resin of Ferula assa- foetida, control group received oral paraffin (Placebo) twice daily for 3 months. The efficacy of this herbal medicines was measured after the 3-month intervention. Hormonal assay for evaluating Testosterone, DEHAS, Prolactin, TSH, FSH, LH levels and also trans abdominal ultrasound for evaluating ovarian volumes, number of follicles of both ovaries, and endometrial thickness. Were measured before and after the study. Results: In this study, significant changes in DEHAS and TSH level were observed (p value<0.03). The greatest reduction in the number of ovarian follicles was reported in the Ferula group (p value <0.00). Conclusion: Use of Ferula assa-foetida can be effected in decrease of DHEAS, TSH levels, and ovarian follicles number in young girls with PCOS.Trial registration: the Iranian Randomized Clinical Trial (IRCT2016040427207N1).url: https://www.irct.ir/trial/22343

scholarly journals Comparison of uterine and ovarian stromal blood flow in patients with polycystic ovarian syndrome

2019 ◽  
Vol 8 (1) ◽  
pp. 50-56
Author(s):  
Ladan Younesi ◽  
Zeinab Safarpour Lima ◽  
Azadeh Akbari Sene ◽  
Zahra Hosseini Jebelli ◽  
Ghazaleh Amjad
Keyword(s):  
Polycystic Ovarian Syndrome ◽  
Color Doppler ◽  
Transvaginal Ultrasound ◽  
Resistance Index ◽  
Ovarian Follicles ◽  
Doppler Spectrum ◽  
Transvaginal Sonography ◽  
Endocrine Disorders ◽  
Gray Scale ◽  
Ovarian Syndrome

Polycystic ovarian syndrome (PCOS) is one of the most common endocrine disorders. The aim of this study was to find the correlation between color Doppler ultrasound and serum tests as auxiliary diagnostic criteria in areas where there is no possibility of some tests. A total of 108 patients were enrolled. They were divided into three groups including patients with PCOS, patients with PCOA ultrasound, patients with ovaries and normal hormone tests. Transvaginal sonography was performed from three groups and the results were evaluated in gray scale. The volume of the ovary, the number of follicles and the placement of follicles were recorded using using Doppler spectrum of uterine artery and ovarian stroma. Their arterial resistance index was also calculated. In the next step, serum samples were evaluated to determine the level of LH, FSH, free testosterone, DHEAS and 17-OHP hormones in the early follicular phase. Gray scale ultrasonographic findings (volume and number of ovarian follicles) as well as LH values were higher in patients with PCOS than those in the other two groups. These results proved the reliability of using these factors in the prediction of PCOS. In this study, Doppler indexes did not correlate with the size of the ovaries, the number of ovarian follicles and the measured hormone levels. The findings of transvaginal ultrasound and investigating the relationship with clinical and laboratory outcomes, a more suitable pattern could be chosen for more accurate patient selection and, leading to timely treatment and reducing the complications of the disease.

Effects of Ferula Assa-Foetida on Clinical, Hormonal and Sonography Parameters in Young Girls with Polycystic Ovary Syndrome: Pilot Randomized, Placebo Controlled, Triple-Blinded

2020 ◽  
Author(s):  
Fatemeh Ghavi ◽  
Somayeh Abdolahian ◽  
Fatemeh Shakeri ◽  
Mahboubeh Taebi
Keyword(s):  
Clinical Trial ◽  
Polycystic Ovarian Syndrome ◽  
Intervention Group ◽  
Ovarian Follicles ◽  
Control Group ◽  
P Value ◽  
Abdominal Sonography ◽  
Ovarian Volume ◽  
Young Girls ◽  
Ovarian Syndrome

Abstract Background: Polycystic ovarian syndrome is the most common endocrine disorder in reproductive aged women. As a result of side effect of pharmaceutical medications women are interested in using alternative medicines to treat. To determine the comparative effects of Ferula assa-foetida on androgenic hormone levels and ovarian features in patient with polycystic ovarian syndrome (PCOS). Methods: In this triple-blinded controlled clinical trial, 34 student participants were randomly divided in two groups. Intervention group received 100 mg of oleo-gum resin of Ferula assa- foetida, control group received oral paraffin (Placebo) twice daily for 3 months. The efficacy of this herbal medicines was measured after the 3-month intervention. Hormonal assay for evaluating Testosterone, DEHAS, Prolactin, TSH, FSH, LH levels and also abdominal sonography for evaluating ovarian volumes, number of follicles of both ovaries, and endometrial thickness. were measured before and after the study.Results: In this study, no significant hormonal changes were observed (p value>0.5). Although the greatest reduction in the number of ovarian follicles and ovarian volume was reported in the Ferula assa-foetide group (p value <0.01). Conclusion: Use of Ferula assa-foetida can be effected in decrease of ovarian volume and ovarian follicles number in young girls with PCOS.Trial registration: the Iranian Randomized Clinical Trial (IRCT2016040427207N1).url: https://www.irct.ir/trial/22343

Characteristics of Polycystic Ovarian Syndrome in Sub-fertile Woman Attending to GOPD in ShSMCH

2019 ◽  
Vol 11 (1) ◽  
pp. 17-23
Author(s):  
Jinnat Ara Islam ◽  
Fatema Ashraf ◽  
Eva Rani Nandi
Keyword(s):  
Polycystic Ovarian Syndrome ◽  
Polycystic Ovaries ◽  
Cross Sectional ◽  
Medical College ◽  
Appropriate Treatment ◽  
Pcos Group ◽  
Symptom Complex ◽  
Ovarian Syndrome ◽  
Selection Of ◽  
Fertile Women

Background: Polycystic ovarian syndrome (PCOS) is a condition characterized by menstrual abnormalities (oligo/amenorrhea) and clinical or biochemical features of hyperandrogenism and may manifest at any age. It is a common cause of female subfertility. All the dimensions of PCOS have not been yet completely explored. Methods: It was a cross sectional comparative study carried out at-GOPD of Shaheed Suhrawardy Medical College & Hospital from January, 2016 to December 2016 on 162 subfertile women. Among them 54 were PCOS group and 108 were non PCOS group. PCOS was diagnosed by (Rotterdam criteria 2003) (i) Oligo or anovulation (ii) hyperandrogenism (iii) Polycystic ovaries. Study was done to evaluate and compare the demographic characteristics, clinical, biochemical and ultrasoundgraphic features of sub-fertile women with and without PCOS. Results: A total of 162 sub-fertile women aged 16-36 years. Mean age was 29.5±5.4. There were significant differences between the two groups in terms of (oligo/amenorrhea), hirsutism, WHR and ovarian ultrasound features. There were no significant differences between two groups in correlations between the level of obesity with the incidence of anovulation, hyperandrogenism or with hormonal features. Conclusion: PCOS is one of the important factors causing Infertility. It is an ill-defined symptom complex needed due attention. There is a need to increase awareness regarding. The clinical features of PCOS are heterogenous thus can be investigated accordingly of selection of appropriate treatment modality. J Shaheed Suhrawardy Med Coll, June 2019, Vol.11(1); 17-23

Impaired DHEA sulfation defines androgen excess in women with polycystic ovarian syndrome (PCOS)

2016 ◽  
Author(s):  
Punith Kempegowda ◽  
Michael W O'Reilly ◽  
Zaki Hassan-Smith ◽  
Karl-Heinz Storbeck ◽  
Angela E Taylor ◽  
...  
Keyword(s):  
Polycystic Ovarian Syndrome ◽  
Androgen Excess ◽  
Ovarian Syndrome
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