Prevalence of Variants in Candidate Genes for Type 2 Diabetes Mellitus in The Netherlands: The Rotterdam Study and the Hoorn Study

1999 ◽  
Vol 84 (3) ◽  
pp. 1002-1006 ◽  
Author(s):  
L. M. 't Hart
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
The Netherlands ◽  
Candidate Genes ◽  
Rotterdam Study

scholarly journals PDB81 - DAPAGLIFLOZIN IS COST-EFFECTIVE COMPARED TO DPP-4 INHIBITORS IN THE TREATMENT OF TYPE 2 DIABETES MELLITUS IN THE NETHERLANDS

2018 ◽  
Vol 21 ◽  
pp. S132
Author(s):  
S.P. Van Olst ◽  
S. Nekeman ◽  
N. van der Linden ◽  
C.A. Uyl-de Groot
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
The Netherlands ◽  
Cost Effective

Degree of glucose control is related to fracture risk in women with type 2 diabetes mellitus: The Rotterdam study

Bone ◽  
2012 ◽  
Vol 50 ◽  
pp. S29
Author(s):  
L. Oei⁎ ◽  
M.C. Zillikens ◽  
A. Dehghan ◽  
M.C. Castano-Betancourt ◽  
K. Estrada ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Fracture Risk ◽  
Glucose Control ◽  
Rotterdam Study

scholarly journals Costs of clinical events in type 2 diabetes mellitus patients in the Netherlands: A systematic review

PLoS ONE ◽  
2019 ◽  
Vol 14 (9) ◽  
pp. e0221856 ◽  
Author(s):  
Alexander V. van Schoonhoven ◽  
Judith J. Gout-Zwart ◽  
Marijke J. S. de Vries ◽  
Antoinette D. I. van Asselt ◽  
Evgeni Dvortsin ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Systematic Review ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
The Netherlands ◽  
Clinical Events

scholarly journals The association between serum uric acid and the incidence of prediabetes and type 2 diabetes mellitus: The Rotterdam Study

PLoS ONE ◽  
2017 ◽  
Vol 12 (6) ◽  
pp. e0179482 ◽  
Author(s):  
Niels van der Schaft ◽  
Adela Brahimaj ◽  
Ke-xin Wen ◽  
Oscar H. Franco ◽  
Abbas Dehghan
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Rotterdam Study

scholarly journals Identification of MEDAG as a Hub Candidate Gene in the Onset and Progression of Type 2 Diabetes Mellitus by Comprehensive Bioinformatics Analysis

2021 ◽  
Vol 2021 ◽  
pp. 1-13
Author(s):  
Jing Yang ◽  
Ping Yu
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Correlation Analysis ◽  
Candidate Gene ◽  
Candidate Genes ◽  
Gene Set Enrichment Analysis ◽  
Coexpression Network ◽  
Pancreas Islet

Objectives. We conducted the present study to identify novel hub candidate genes in the pathogenesis of type 2 diabetes mellitus (T2DM) and provide potential biomarkers or therapeutic targets for dealing with the disease. Methods. We conducted weighted gene coexpression network analysis on a series of the expression profiles of the pancreas islet of T2DM patients obtained from the Gene Expression Omnibus database to construct a weighted coexpression network. After dividing genes into separated coexpression modules, we identified a T2DM-related module using Pearson’s correlation analysis. Then, hub genes were identified from the T2DM-related module using the Maximal Clique Centrality method and validated by correlation analysis with clinical traits, differentially expressed gene analysis, validation in other datasets, and single-gene gene set enrichment analysis (GSEA). Results. Genes were divided into 16 coexpression modules, and one module was identified as a T2DM-related module. Four hub candidate genes were identified, and MEDAG was a novel hub candidate gene. The expression level of MEDAG was positively correlated with hemoglobin A1c (HbA1c) and was evidently overexpressed in the pancreas islet tissue of T2DM patients compared with normal control. Analyses on two other datasets supported the results. GSEA verified that MEDAG plays essential roles in T2DM. Conclusions. MEDAG is a novel hub candidate of T2DM, and its irregular expression in the pancreas islet plays vital roles in the pathogenesis of T2DM. MEDAG is a potential target of intervention in the future for the treatment of T2DM.

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