Prostaglandins: Modulators of Renal Function and Pressor Resistance in Chronic Liver Disease*

1979 ◽  
Vol 48 (6) ◽  
pp. 895-900 ◽  
Author(s):  
ROBERT D. ZIPSER ◽  
JOHN C. HOEFS ◽  
PAUL F. SPECKART ◽  
PRISCILLA K. ZIA ◽  
RICHARD HORTON
Keyword(s):  
Renal Function ◽  
Liver Disease ◽  
Chronic Liver Disease ◽  
Chronic Liver

Diuretics in critical illness

2016 ◽  
Author(s):  
Marlies Ostermann ◽  
Ruth Y. Y. Wan
Keyword(s):  
Heart Failure ◽  
Chronic Kidney Disease ◽  
Congestive Heart Failure ◽  
Renal Function ◽  
Liver Disease ◽  
Kidney Disease ◽  
Chronic Liver Disease ◽  
Fluid Overload ◽  
Chronic Liver ◽  
Risk Of Death

Fluid overload and chronic hypertension are the most common indications for diuretics. The diuretic response varies between different types and depends on underlying renal function. In patients with congestive heart failure, diuretics appear to reduce the risk of death and worsening heart failure compared with placebo, but their use in acute decompensated heart failure is questionable. Diuretics are also widely used in chronic kidney disease to prevent or control fluid overload, and treat hypertension. In acute kidney injury, there is no evidence that they improve renal function, speed up recovery, or change mortality. In patients with chronic liver disease and large volume ascites, paracentesis is more effective and associated with fewer adverse events than diuretic therapy, but maintenance treatment with diuretics is indicated to prevent recurrence of ascites. Mannitol has a role in liver patients with cerebral oedema and normal renal function. The use of diuretics in rhabdomyolysis is controversial and restricted to patients who are not fluid deplete. In conditions associated with resistant oedema (chronic kidney disease, congestive heart failure, chronic liver disease), combinations of diuretics with different modes of action may be necessary. Diuresis is easier to achieve with a continuous furosemide infusion compared with intermittent boluses, but there is no evidence of better outcomes. The role of combination therapy with albumin in patients with fluid overload and severe hypoalbuminaemia is uncertain with conflicting data.

scholarly journals Tu1584 – Strong Effect of Lusutrombopag in Patients with Chronic Liver Disease and Its Relationship to Renal Function

2019 ◽  
Vol 156 (6) ◽  
pp. S-1368
Author(s):  
Hirohito Takeuchi ◽  
Yoshihiro Furuichi ◽  
Masakazu Abe ◽  
Yoshitaka Kasai ◽  
Katsutoshi Sugimoto ◽  
...  
Keyword(s):  
Renal Function ◽  
Liver Disease ◽  
Chronic Liver Disease ◽  
Chronic Liver

scholarly journals Frequency and Characteristics of Overestimated Renal Function in Japanese Patients with Chronic Liver Disease and Its Relation to Sarcopenia

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2415
Author(s):  
Sonoe Yoshida ◽  
Goki Suda ◽  
Masatsugu Ohara ◽  
Qingjie Fu ◽  
Zijian Yang ◽  
...  
Keyword(s):  
Renal Function ◽  
Liver Disease ◽  
Chronic Liver Disease ◽  
Muscle Mass ◽  
High Frequency ◽  
Psoas Muscle ◽  
Japanese Patients ◽  
Multivariate Regression Analysis ◽  
Chronic Liver ◽  
Function Loss

Renal dysfunction and sarcopenia are important prognostic factors in patients with chronic liver disease (CLD). Muscle atrophy can cause the overestimation of renal function based on serum creatinine. However, the frequency of overestimated renal function in Japanese patients with CLD and its relationship with sarcopenia are unclear. In present study, we evaluated the frequency of overestimated renal function, defined as a >20% higher eGFR using creatinine than using cystatin C, in 307 patients with CLD as well as its relationship with indicators of sarcopenia. In total, 24.8% of patients had overestimated renal function. In a multivariate regression analysis, liver cirrhosis (p = 0.004) and psoas muscle mass index (p = 0.049) were significantly associated with overestimated renal function. Loss of skeletal muscle mass was significantly more frequent in both male and female patients with overestimated renal function than without. In males, the loss of muscle strength and rate of sarcopenia, defined as loss of muscle mass and strength, were significantly higher in patients with than without overestimated renal function. The high frequency of overestimated renal function in Japanese patients suggests that indicators of renal function should be carefully considered; furthermore, monitoring and interventions for both renal function and sarcopenia are needed in patients with CLD.

scholarly journals The Prevalence of Chronic Liver Disease: Implications for Renal Impairment

2015 ◽  
Vol 61 (3) ◽  
pp. 168-171
Author(s):  
Sala Nicoleta ◽  
Bancu Ligia ◽  
Ureche Corina ◽  
Botoman Maria ◽  
Simon Ionela ◽  
...  
Keyword(s):  
Renal Function ◽  
Portal Hypertension ◽  
Liver Disease ◽  
Chronic Liver Disease ◽  
Age Distribution ◽  
Male Gender ◽  
Chronic Liver ◽  
Mean Values ◽  
Advanced Stages ◽  
Gi Bleed

Abstract Introduction. Renal disease plays an important role in the prognosis and evolution of chronic liver disease, in particular in its advanced stages. The aim of our study is to analyze the prevalence of chronic liver disease (hepatitis and cirrhosis of different etiologies) and to assess possible correlations between these and impaired renal function. Material and methods. We conducted a retrospective observational study based on data collected from observation charts of patients admitted to the 2nd Medical Clinic, Emergency County Hospital Tirgu-Mures between January 1st 2012-December 31 2013. In this study we included, based on informed consent, 401 patients with documented liver pathology, with preserved or modified renal function. Results. Age distribution shows that 41.1% of cases occured between 51 and 60 years of age. Sex distribution shows that 65.3% of cases were male. Toxic cirrhosis was found in 40.8% of males and viral C cirrhosis in 15.1% of women. Toxic cirrhosis associated the following complications: ascites (35.7%), encephalopathy (75%), PAH (68.6%), esophageal varices and upper GI bleed (35.7%). Analyzing the risk factors of renal failure we found that increased mean values of creatinine are associated with viral B cirrhosis (p = 0.02), portal vein diameter (OR 1.37), portal hypertension (OR 1.24), male gender (OR 1.84) and the age group 61-70 yo (OR 1.04). Conclusions. The current study demonstrated that renal function in chronic liver disease correlates with viral etiology of liver disease, its advanced stage, presence of portal hypertension, older age and male gender.

scholarly journals Clinical Profile of Ascites Based on Presentation and Laboratory Findings: An institutional experience from Kathmandu, Nepal

2018 ◽  
Vol 2 (1) ◽  
pp. e000101
Author(s):  
Rinku Joshi ◽  
Dhan Bahadur Shrestha ◽  
Rajib Pande ◽  
Sukriti Maharjan
Keyword(s):  
Renal Function ◽  
Liver Disease ◽  
Liver Function ◽  
Chronic Liver Disease ◽  
Fluid Collection ◽  
Chronic Liver ◽  
Clinical Feature ◽  
Total Serum ◽  
Laboratory Findings ◽  
Tertiary Center

Introduction: Ascites is the fluid collection in the potential space of the peritoneal cavity. Alcoholic liver disease and intra-abdominal malignancy are two major etiologies behind it. Also, diagnosis of tuberculous ascites should be thought of due to endemicity. Cirrhotic patients at any time during the course of disease, invariably present with ascites which is one of the marker of decompensation. In our context, etiology behind ascites and its correlation with symptoms and clinical findings not yet studied, so present study is conceptualized. Methods:This is a cross-sectional retrospective descriptive hospital based record review of patients presented with ascites in a tertiary center of Kathmandu. One hundred fourteen patients with ascites under regular follow up of Shree Birendra Hospital (SBH) were reviewed. Data regarding presenting complaints, examination findings, relevant investigations during first visit and final diagnosis were retrieved from our own record keeping and recorded information were then evaluated. Results: Patients having ascites have myriad of symptoms and signs, commonest clinical feature being icterus (74, 64.9%). Most of them were anemic at presentation. Forty-two (36.8%) had high blood urea and 36 (31.5%) with high creatinine suggesting approximately 30-40% cases presented with deranged renal function test. Ninety-three (81.5%) had raised total serum bilirubin. Similarly, PT/INR derangements were in 74 (64.9%) and 57 (50%) suggesting deranged liver function. Serum albumin was less than 3.5 gram/deciliter in 83(72.8%) cases. Among the patients studied, 80 (70.1%) had high Serum-Ascites Abumin Gradient (SAAG) suggesting transudative type of ascites and rest 34 had low SAAG suggesting exudative type of ascites. Overall assessment revealed, majority of patients (71.05%) had Chronic liver disease (CLD) as the cause of ascites. Conclusions: Ascites due to chronic liver disease was the main finding with etiology supported by laboratory findings. Significant numbers of the patients had deranged renal function on top of liver function derangement, so these parameters need to be properly taken care of. Key Words: Ascites, liver cirrhosis, serum ascetic albumin gradient.

Genetic predictors of spontaneous viral elimination or chronic liver disease in hepatitis C infection

2001 ◽  
Vol 120 (5) ◽  
pp. A7-A7
Author(s):  
S ROSS ◽  
S MASCHERETTI ◽  
H HINRICHSEN ◽  
P BUGGISCH ◽  
U FOELSCH ◽  
...  
Keyword(s):  
Liver Disease ◽  
Hepatitis C ◽  
Chronic Liver Disease ◽  
Chronic Liver ◽  
Hepatitis C Infection ◽  
Genetic Predictors
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