Influence of Continuous Gonadotropin-Releasing Hormone (GnRH) Agonist Treatment on Luteinizing Hormone and Testosterone Secretion, the Response to GnRH, and the Testicular Response to Human Chorionic Gonadotropin in Male Rhesus Monkeys*

1984 ◽  
Vol 58 (2) ◽  
pp. 262-267 ◽  
Author(s):  
DAVID R. MANN ◽  
KENNETH G. GOULD ◽  
DELWOOD C. COLLINS
Keyword(s):  
Luteinizing Hormone ◽  
Chorionic Gonadotropin ◽  
Gnrh Agonist ◽  
Human Chorionic Gonadotropin ◽  
Rhesus Monkeys ◽  
Gonadotropin Releasing Hormone ◽  
Releasing Hormone ◽  
Testosterone Secretion ◽  
Male Rhesus

Initiation and control of ovulation in the mouse luteal phases. Effects of gonadotropins and gonadotropin releasing hormone

1986 ◽  
Vol 113 (4) ◽  
pp. 576-581
Author(s):  
A. A. Gidley-Baird ◽  
B. M. White ◽  
J. Hau ◽  
O. M. Poulsen
Keyword(s):  
Luteinizing Hormone ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Gonadotropin Releasing Hormone ◽  
Follicular Growth ◽  
Releasing Hormone ◽  
No Release ◽  
Vehicle Injection ◽  
And Control ◽  
Murine Pregnancy

Abstract. The aim of the present study was to examine the induction of ovulation during pregnancy, pseudopregnancy, and suckling-delayed pregnancy in mice using exogenous gonadotropins. The present results demonstrate that there are mature follicles in the ovary which can be induced to ovulate with administration of either exogenous human chorionic gonadotropin (hCG) or luteinizing hormone (LH) during pregnancy (Days 1–12) and pseudopregnancy (Days 4–8) in the mouse. hCG was relatively ineffective in initiating ovulation during suckling-delayed pregnancy, and hCG could not induce ovulation on Days 3–6 in any animals, suggesting that follicular growth is not continuous during suckling-delayed pregnancy in the mouse. Ovulation occurred in pregnant and pseudopregnant mice following injection of gonadotropin releasing hormone (GnRH) in a gelatin delay vehicle. Injection of GnRH in saline did not initiate ovulation in pregnant or pseudopregnant mice. A large release of LH was shown to occur following injection of GnRH in gelatin, but no release occurred after the same dose of GnRH in saline. In conclusion, the experiments demonstrate the existence of mature follicles during murine pregnancy and pseudopregnancy, and the lack of inductable follicles during suckling-delayed pregnancy.

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