scholarly journals Effects of Sex Steroid Deprivation/Administration on Hair Growth and Skin Sebum Production in Transsexual Males and Females

2000 ◽  
Vol 85 (8) ◽  
pp. 2913-2921 ◽  
Author(s):  
E. J. Giltay ◽  
L. J. G. Gooren
Keyword(s):  
Hair Growth ◽  
Sex Steroid ◽  
Sebum Production ◽  
Males And Females

EFFECT OF SEX AND AGE AT GONADECTOMY ON THE SEBACEOUS RESPONSE TO PROGESTERONE

1977 ◽  
Vol 73 (1) ◽  
pp. 67-70 ◽  
Author(s):  
SAM SHUSTER ◽  
WENDY M. HINKS ◽  
A. J. THODY
Keyword(s):  
Adult Female ◽  
Adult Male ◽  
Female Rats ◽  
Male Rats ◽  
Adult Males ◽  
Adult Rat ◽  
Sebum Production ◽  
Males And Females ◽  
Sebum Secretion

SUMMARY The effect of progesterone on the rate of sebum secretion was examined in intact and gonadectomized rats. In intact, adult, male rats, progesterone administered for 3 weeks decreased sebum secretion; after castration of adult males, progesterone increased sebum secretion and an even greater response occurred in males castrated at 21 days of age. In intact, adult, female rats progesterone slightly increased sebum production. As in the male, the response was affected by the time of gonadectomy, a greater response occurring after spaying at 21 days compared with 10 weeks of age. Thus, the response to progesterone in the adult rat differs in intact males and females and is affected by changes in the endocrine environment induced by gonadectomy, especially near the time of puberty.

scholarly journals Role of Androgen on Physiological Function of Pilosebaceous Unit

2021 ◽  
Vol 5 (3) ◽  
pp. 573-579
Author(s):  
Inda Astri Aryani ◽  
Cayadi Sidarta Antonius ◽  
Suroso Adi Nugroho ◽  
Nopriyati
Keyword(s):  
Hair Growth ◽  
Androgen Receptors ◽  
Physiological Function ◽  
Steroid Hormone ◽  
Hair Follicles ◽  
Sebaceous Glands ◽  
Pilosebaceous Unit ◽  
Sebum Production ◽  
Dermal Papillae

The pilosebaceous unit is a sebaceous gland with hair follicles. One of the hormones that affects the pilosebaceous unit is androgen, a steroid hormone that plays an important role in the expression of the phenotype of men and women. Androgen consist of testosterone and dihydrotestosterone which are activated by androgen receptors. Androgen in the pilosebaceous unit affect sebum production and hair growth. Androgen receptors in the sebaceous glands are found on sebocytes and in hair follicles in the dermal papillae of hair follicles

Exposure of managed red river hogs (Potamochoerus porcus) to urine from males stimulates estrous cycling and modulates fecal sex steroid metabolites in males and females

2020 ◽  
Vol 285 ◽  
pp. 113262 ◽  
Author(s):  
Camille Goblet ◽  
Bryce Lewis ◽  
Victoria Jacobsen ◽  
Monica Jarboe ◽  
Dameriss Silva ◽  
...  
Keyword(s):  
Red River ◽  
Sex Steroid ◽  
Males And Females ◽  
Estrous Cycling

scholarly journals Changes in plasma steroid hormones and gonadal histology associated with sexual maturation in wild southern hake (Merluccius australis)

2017 ◽  
Vol 43 (4) ◽  
pp. 632-640
Author(s):  
Manuel Alvarado ◽  
Edison Serrano ◽  
Juan Carlos Sánchez ◽  
Luis Valladares
Keyword(s):  
Steroid Hormones ◽  
Steroid Hormone ◽  
Sex Steroid Hormones ◽  
Sex Steroid ◽  
Sex Steroid Hormone ◽  
Asynchronous Development ◽  
Gonadal Histology ◽  
Males And Females ◽  
First Time

A detailed study of gametes development and characterization of plasma sex steroid hormones during the maturation cycle was performed for the first time in the southern hake (Merluccius australis). Fish were caught in the inland waters of the Reloncaví Sound, Interior Sea of Chiloé, Chile. Samples of gonads and blood were collected for histology and sex steroid hormone (17 β-estradiol, 11-ketotestosterone and 17,20 βdihydroxy-4-pregnen-3-one) analysis, respectively. Sex steroid hormone quantification was performed using enzyme-immunoassay (ELISA). Results showed that M. australis males and females have asynchronous development of testicles and ovaries, in all stages of maturation. Most spawning fish were found during the spring months. Regarding the sex steroid hormones, serological fluctuations of 17 β-estradiol and 11- ketotestosterone were found during gonadal maturation of M. australis. These hormones are the main hormones responsible for vitelogenesis and spermatogenesis processes, respectively. Conversely, 17,20 β-dihydroxy-4- pregnen-3-one did not show any serological fluctuation in females and males. Further studies involving gonadotropins, 17,20 β,21-trihydroxy-4-pregnen-3-one and vitellogenin quantification are required in order to obtain a more complete description of the reproductive physiology of wild and farmed M. australis.  

scholarly journals Combination therapy with oral minoxidil and dutasteride in the treatment of male patterned baldness: A case report

2022 ◽  
Vol 2 ◽  
pp. 4
Author(s):  
Shashank Bansod
Keyword(s):  
Case Report ◽  
Side Effects ◽  
Combination Therapy ◽  
Hair Growth ◽  
Reductase Inhibitor ◽  
Medical Condition ◽  
Psychological Impact ◽  
Short Period ◽  
Oral Form ◽  
Males And Females

Androgenetic alopecia is a medical condition with a deep social and psychological impact on the affected individuals and is characterized by progressive hair thinning, leading to hair loss over the scalp in both males and females. Minoxidil in oral form is primarily an antihypertensive drug, whose mechanism of action is not completely known. Dutasteride is a 5-alpha reductase inhibitor, acting on both alpha-1 and alpha-2 receptors. The author combined these two agents for the treatment of male patterned baldness and found that this combination imparts a visible increase in hair thickness, density, and new hair growth in the patient, within a short period causing minimal side effects.

QUANTITATIVE STUDIES OF HAIR GROWTH IN THE ALBINO RAT

1958 ◽  
Vol 16 (4) ◽  
pp. 360-368 ◽  
Author(s):  
ELIZABETH JOHNSON
Keyword(s):  
Hair Growth ◽  
Ovarian Hormones ◽  
The Body ◽  
Female Rats ◽  
Inhibitory Effects ◽  
Albino Rat ◽  
Adrenal Hormones ◽  
Quantitative Studies ◽  
Males And Females ◽  
Second Wave

SUMMARY 1. Adrenalectomy 2 weeks before the start of the second wave of hair growth advanced the beginning of the wave in female rats, and speeded its passage over the body in both males and females. The rate of loss of club hairs was slightly accelerated, but there was no effect on the definitive length of hair produced. 2. Adrenalectomy after the wave of hair growth had begun was less effective. 3. ACTH did not affect the time at which the wave of hair growth began but delayed its passage. ACTH had no effect on the loss of club hairs nor on the definitive length of hair produced. 4. Implantation of oestradiol retarded the start and rate of passage of the wave, and the loss of club hairs in both spayed and spayed adrenalectomized animals. Oestradiol must therefore have some action which is independent of the adrenals. Nevertheless, inhibitory effects of oestradiol on these aspects of hair growth were enhanced by the presence of the adrenals. The action of oestradiol in reducing the rate of hair growth was, on the other hand, unaffected by the presence or absence of the adrenals. 5. Adrenal hormones delay the passage of the growth wave to a greater extent than ovarian hormones, but they have no effect on the rate of hair growth, and, compared with ovarian hormones, affect the loss of club hairs only slightly. It is therefore suggested that these three main phases of hair growth may be controlled by mechanisms which are at least partially independent.

scholarly journals In utero low-protein-diet-programmed type 2 diabetes in adult offspring is mediated by sex hormones in rats†

2020 ◽  
Vol 103 (5) ◽  
pp. 1110-1120
Author(s):  
Chellakkan S Blesson ◽  
Amy K Schutt ◽  
Vidyadharan A Vipin ◽  
Daren T Tanchico ◽  
Pretty R Mathew ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Glucose Metabolism ◽  
Glucose Intolerance ◽  
Sex Steroid ◽  
Euglycemic Hyperinsulinemic Clamp ◽  
Pregnant Rats ◽  
Low Protein ◽  
Males And Females

Abstract Sex steroids regulate insulin sensitivity and glucose metabolism. We had characterized a lean type 2 diabetes (T2D) rat model using gestational low-protein (LP) diet programming. Our objective was to identify if endocrine dysfunction leading to decreased sex hormone levels will precede the development of T2D and if steroid replacement will prevent the onset of the disease. Pregnant rats were fed control or isocaloric LP diet from gestational day 4 until delivery. Normal diet was given to all mothers after delivery and to pups after weaning. LP offspring developed glucose intolerance and insulin resistance at 4 months. We measured sex steroid hormone profiles and expression of key genes involved in steroidogenesis in testis and ovary. Furthermore, one-month old rats were implanted with 90-day slow release T and E2 pellets for males and females, respectively. Glucose tolerance test (GTT) and euglycemic hyperinsulinemic clamp was performed at 4 months. LP-programmed T2D males had low T levels and females had low E2 levels due to dysregulated gene expression during steroidogenesis in gonads. GTT and euglycemic hyperinsulinemic clamp showed that LP males and females were glucose intolerant and insulin resistant; however, steroid supplementation prevented the onset of glucose intolerance and insulin resistance. Rats that developed T2D by LP programming have compromised gonadal steroidogenesis leading to low T and E2 in males and females, respectively. Sex steroid supplementation prevented the onset of glucose intolerance and insulin resistance indicating low sex steroid levels could cause compromised glucose metabolism ultimately leading to T2D.

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