Exposure of managed red river hogs (Potamochoerus porcus) to urine from males stimulates estrous cycling and modulates fecal sex steroid metabolites in males and females

2020 ◽  
Vol 285 ◽  
pp. 113262 ◽  
Author(s):  
Camille Goblet ◽  
Bryce Lewis ◽  
Victoria Jacobsen ◽  
Monica Jarboe ◽  
Dameriss Silva ◽  
...  
Keyword(s):  
Red River ◽  
Sex Steroid ◽  
Males And Females ◽  
Estrous Cycling

scholarly journals Kiss1 −/− Mice Exhibit More Variable Hypogonadism than Gpr54−/− Mice

Endocrinology ◽  
2007 ◽  
Vol 148 (10) ◽  
pp. 4927-4936 ◽  
Author(s):  
Risto Lapatto ◽  
J. Carl Pallais ◽  
Dongsheng Zhang ◽  
Yee-Ming Chan ◽  
Amy Mahan ◽  
...  
Keyword(s):  
Sexual Maturation ◽  
Knockout Mice ◽  
Genetic Background ◽  
Phenotypic Variability ◽  
Hypogonadotropic Hypogonadism ◽  
Vaginal Opening ◽  
Wild Type ◽  
Males And Females ◽  
G Protein Coupled ◽  
Estrous Cycling

The G protein-coupled receptor Gpr54 and its ligand metastin (derived from the Kiss1 gene product kisspeptin) are key gatekeepers of sexual maturation. Gpr54 knockout mice demonstrate hypogonadotropic hypogonadism, but until recently, the phenotype of Kiss1 knockout mice was unknown. This report describes the reproductive phenotypes of mice carrying targeted deletions of Kiss1 or Gpr54 on the same genetic background. Both Kiss1 and Gpr54 knockout mice are viable but infertile and have abnormal sexual maturation; the majority of males lack preputial separation, and females have delayed vaginal opening and absence of estrous cycling. Kiss1 and Gpr54 knockout males have significantly smaller testes compared with controls. Gpr54 knockout females have smaller ovaries and uteri than wild-type females. However, Kiss1 knockout females demonstrate two distinct phenotypes: half have markedly reduced gonadal weights similar to those of Gpr54 knockout mice, whereas half exhibit persistent vaginal cornification and have gonadal weights comparable with those of wild-type females. FSH levels in both Kiss1 and Gpr54 knockout males and females are significantly lower than in controls. When injected with mouse metastin 43–52, a Gpr54 agonist, Gpr54 knockout mice fail to increase gonadotropins, whereas Kiss1 knockout mice respond with increased gonadotropin levels. In summary, both Kiss1 and Gpr54 knockout mice have abnormal sexual maturation consistent with hypogonadotropic hypogonadism, although Kiss1 knockout mice appear to be less severely affected than their receptor counterparts. Kiss1 knockout females demonstrate a bimodal phenotypic variability, with some animals having higher gonadal weight, larger vaginal opening, and persistent vaginal cornification.

scholarly journals Changes in plasma steroid hormones and gonadal histology associated with sexual maturation in wild southern hake (Merluccius australis)

2017 ◽  
Vol 43 (4) ◽  
pp. 632-640
Author(s):  
Manuel Alvarado ◽  
Edison Serrano ◽  
Juan Carlos Sánchez ◽  
Luis Valladares
Keyword(s):  
Steroid Hormones ◽  
Steroid Hormone ◽  
Sex Steroid Hormones ◽  
Sex Steroid ◽  
Sex Steroid Hormone ◽  
Asynchronous Development ◽  
Gonadal Histology ◽  
Males And Females ◽  
First Time

A detailed study of gametes development and characterization of plasma sex steroid hormones during the maturation cycle was performed for the first time in the southern hake (Merluccius australis). Fish were caught in the inland waters of the Reloncaví Sound, Interior Sea of Chiloé, Chile. Samples of gonads and blood were collected for histology and sex steroid hormone (17 β-estradiol, 11-ketotestosterone and 17,20 βdihydroxy-4-pregnen-3-one) analysis, respectively. Sex steroid hormone quantification was performed using enzyme-immunoassay (ELISA). Results showed that M. australis males and females have asynchronous development of testicles and ovaries, in all stages of maturation. Most spawning fish were found during the spring months. Regarding the sex steroid hormones, serological fluctuations of 17 β-estradiol and 11- ketotestosterone were found during gonadal maturation of M. australis. These hormones are the main hormones responsible for vitelogenesis and spermatogenesis processes, respectively. Conversely, 17,20 β-dihydroxy-4- pregnen-3-one did not show any serological fluctuation in females and males. Further studies involving gonadotropins, 17,20 β,21-trihydroxy-4-pregnen-3-one and vitellogenin quantification are required in order to obtain a more complete description of the reproductive physiology of wild and farmed M. australis.  

scholarly journals In utero low-protein-diet-programmed type 2 diabetes in adult offspring is mediated by sex hormones in rats†

2020 ◽  
Vol 103 (5) ◽  
pp. 1110-1120
Author(s):  
Chellakkan S Blesson ◽  
Amy K Schutt ◽  
Vidyadharan A Vipin ◽  
Daren T Tanchico ◽  
Pretty R Mathew ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Glucose Metabolism ◽  
Glucose Intolerance ◽  
Sex Steroid ◽  
Euglycemic Hyperinsulinemic Clamp ◽  
Pregnant Rats ◽  
Low Protein ◽  
Males And Females

Abstract Sex steroids regulate insulin sensitivity and glucose metabolism. We had characterized a lean type 2 diabetes (T2D) rat model using gestational low-protein (LP) diet programming. Our objective was to identify if endocrine dysfunction leading to decreased sex hormone levels will precede the development of T2D and if steroid replacement will prevent the onset of the disease. Pregnant rats were fed control or isocaloric LP diet from gestational day 4 until delivery. Normal diet was given to all mothers after delivery and to pups after weaning. LP offspring developed glucose intolerance and insulin resistance at 4 months. We measured sex steroid hormone profiles and expression of key genes involved in steroidogenesis in testis and ovary. Furthermore, one-month old rats were implanted with 90-day slow release T and E2 pellets for males and females, respectively. Glucose tolerance test (GTT) and euglycemic hyperinsulinemic clamp was performed at 4 months. LP-programmed T2D males had low T levels and females had low E2 levels due to dysregulated gene expression during steroidogenesis in gonads. GTT and euglycemic hyperinsulinemic clamp showed that LP males and females were glucose intolerant and insulin resistant; however, steroid supplementation prevented the onset of glucose intolerance and insulin resistance. Rats that developed T2D by LP programming have compromised gonadal steroidogenesis leading to low T and E2 in males and females, respectively. Sex steroid supplementation prevented the onset of glucose intolerance and insulin resistance indicating low sex steroid levels could cause compromised glucose metabolism ultimately leading to T2D.

scholarly journals A Review on Sex Steroid Hormone Estrogen Receptors in Mammals and Fish

2020 ◽  
Vol 2020 ◽  
pp. 1-9 ◽  
Author(s):  
Eric Amenyogbe ◽  
Gang Chen ◽  
Zhongliang Wang ◽  
Xiaoying Lu ◽  
Mingde Lin ◽  
...  
Keyword(s):  
Estrogen Receptors ◽  
Steroid Hormones ◽  
Steroid Hormone ◽  
Sex Steroid ◽  
Reproductive Hormone ◽  
Binding Affinities ◽  
Sex Steroid Hormone ◽  
Central Nervous Systems ◽  
Males And Females

Steroid hormones play essential roles in the reproductive biology of vertebrates. Estrogen exercises its effect through estrogen receptors and is not only a female reproductive hormone but acts virtually in all vertebrates, including fish, and is involved in the physiological and pathological states in all males and females. Estrogen has been implicated in mandible conservation and circulatory and central nervous systems as well as the reproductive system. This review intended to understand the structure, function, binding affinities, and activations of estrogens and estrogen receptors and to discuss the understanding of the role of sex steroid hormone estrogen receptors in mammals and fish.

Bronchial stereocilia in the immotile cilia syndrome: A case report

1984 ◽  
Vol 42 ◽  
pp. 52-53
Author(s):  
George Price ◽  
Lizardo Cerezo
Keyword(s):  
Surface Modifications ◽  
Respiratory Epithelium ◽  
Immotile Cilia ◽  
Kartagener's Syndrome ◽  
Membrane Blebs ◽  
Radial Spokes ◽  
Males And Females ◽  
Dynein Arms ◽  
Ultrastructural Finding ◽  
Ultrastructural Findings

Ultrastructural defects of ciliary structure have been known to cause recurrent sino-respiratory infection concurrent with Kartagener's syndrome. (1,2,3) These defects are also known to cause infertility in both males and females. (4) Overall, the defects are defined as the Immotile, or Dyskinetic Cilia Syndrome (DCS). Several ultrastructural findings have been described, including decreased number of cilia, multidirection orientation, fused and compound cilia, membrane blebs, excess matrix in the axoneme, missing outer tubular doublets, translocated doublets, defective radial spokes and dynein arms. A rare but noteworthy ultrastructural finding in DCS is the predominance of microvilli-like structures on the luminal surface of the respiratory epithelium. (5,6) These permanent surface modifications of the apical respiratory epithelium no longer resemble cilia but reflect the ultrastructure of stereocilia, similar to that found in the epidydimal epithelium. Like microvilli, stereocilia are devoid of microtubular ultrastructure in comparison with true cilia.

Female sex steroid induced gallbladder epithelium changes and gallstone deposits in female hamsters: TEM and SEM aspects

1993 ◽  
Vol 51 ◽  
pp. 354-355
Author(s):  
S. Karkare ◽  
J. Gilloteaux ◽  
T. R. Kelly
Keyword(s):  
Hormone Receptors ◽  
Corn Oil ◽  
Estrogen Therapy ◽  
Gallstone Formation ◽  
The United States ◽  
Sex Steroid ◽  
Estradiol Valerate ◽  
Surface Epithelium ◽  
Female Sex ◽  
Purina Chow

Approximately 1 million people in the United States alone develop gallstones each year. The incidence is higher in women than in men and the ratio being 4 ≥ 1. A correlation has also been suggested between oral contraceptives and cholelithiasis. In addition, postmenopausal or cancer estrogen therapy has been reported to be a factor responsible for gallstone formation. Female sex hormone receptors have been detected not only in the gallbladder musculature, but also in its epithelium. As a follow up to experiments effectuated in the male and the ovariectomized Syrian hamster, this report shows that, a combination of a low cholesterol diet with female sex steroid treatment contributes to the formation of gallstone-like deposits, while modifying the surface epithelium morphology. Syrian hamsters (F1B strain, BioBreeders, Watertown MA) were housed under 12h light: 12 h dark cycle, at 20 °C, fed Purina chow and water ad libitum. Several duration/treatment groups were studied, but this report will focus on data obtained with the group injected weekly with estradiol valerate (E weekly, s.c. 8-10 μg/100 g.b.w., in corn oil) and with i.m. medroxyprogesterone acetate (DepoProvera Upjohn Co., Kalamazoo, MI; 8-10 mg/100 g.b.w.) for a 3-month period. Other parameters (blood and bile) were also studied but not reported here.

The dual nature of obesity in metabolic programming: quantity versus quality of adipose tissue

2020 ◽  
Vol 134 (18) ◽  
pp. 2447-2451
Author(s):  
Anissa Viveiros ◽  
Gavin Y. Oudit
Keyword(s):  
Adipose Tissue ◽  
Environmental Factors ◽  
Maternal Obesity ◽  
Metabolic Programming ◽  
Dual Nature ◽  
Prevalence Of Obesity ◽  
Adipose Tissue Volume ◽  
Males And Females ◽  
Metabolically Healthy

Abstract The global prevalence of obesity has been rising at an alarming rate, accompanied by an increase in both childhood and maternal obesity. The concept of metabolic programming is highly topical, and in this context, describes a predisposition of offspring of obese mothers to the development of obesity independent of environmental factors. Research published in this issue of Clinical Science conducted by Litzenburger and colleagues (Clin. Sci. (Lond.) (2020) 134, 921–939) have identified sex-dependent differences in metabolic programming and identify putative signaling pathways involved in the differential phenotype of adipose tissue between males and females. Delineating the distinction between metabolically healthy and unhealthy obesity is a topic of emerging interest, and the precise nature of adipocytes are key to pathogenesis, independent of adipose tissue volume.

The Hearing Aid Effect in African American and Caucasian Males as Perceived by Female Judges of the Same Race

1999 ◽  
Vol 30 (2) ◽  
pp. 165-172 ◽  
Author(s):  
Mary Davis ◽  
Rhonda Jackson ◽  
Tina Smith ◽  
William Cooper
Keyword(s):  
African American ◽  
Hearing Aids ◽  
Undergraduate Education ◽  
Hearing Aid ◽  
Semantic Differential ◽  
Semantic Differential Scale ◽  
Education Majors ◽  
Female Undergraduate ◽  
Lay Persons ◽  
Males And Females

Prior studies have proven the existence of the "hearing aid effect" when photographs of Caucasian males and females wearing a body aid, a post-auricular aid (behind-the-ear), or no hearing aid were judged by lay persons and professionals. This study was performed to determine if African American and Caucasian males, judged by female members of their own race, were likely to be judged in a similar manner on the basis of appearance, personality, assertiveness, and achievement. Sixty female undergraduate education majors (30 African American; 30 Caucasian) used a semantic differential scale to rate slides of preteen African American and Caucasian males, with and without hearing aids. The results of this study showed that female African American and Caucasian judges rated males of their respective races differently. The hearing aid effect was predominant among the Caucasian judges across the dimensions of appearance, personality, assertiveness, and achievement. In contrast, the African American judges only exhibited a hearing aid effect on the appearance dimension.

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