scholarly journals Effect of Exogenous Cholecystokinin (CCK)-8 on Food Intake and Plasma CCK, Leptin, and Insulin Concentrations in Older and Young Adults: Evidence for Increased CCK Activity as a Cause of the Anorexia of Aging

2001 ◽  
Vol 86 (12) ◽  
pp. 5830-5837 ◽  
Author(s):  
Caroline G. MacIntosh ◽  
John E. Morley ◽  
Judith Wishart ◽  
Howard Morris ◽  
Jan B. M. J. Jansen ◽  
...  
Keyword(s):  
Food Intake ◽  
Older People ◽  
Healthy Aging ◽  
Protein Energy Malnutrition ◽  
Age Groups ◽  
Postprandial Glucose ◽  
Saline Control ◽  
Older Subjects ◽  
Young Subjects ◽  
The Impact

Healthy aging is associated with reductions in appetite and food intake—the so-called anorexia of aging, which may predispose to protein-energy malnutrition. One possible cause of the anorexia of aging is an increased satiating effect of cholecystokinin (CCK). To investigate the impact of aging on the satiating effects of CCK, 12 young and 12 older healthy subjects received 25-min iv infusions of saline (control) and CCK-8, 1 ng/kg per min or 3 ng/k per min, on 3 separate days before a test meal. Older subjects ate less than young subjects, and food intake was suppressed 21.6% by CCK-8, compared with the control day (P < 0.05). The suppression of energy intake by CCK-8 in older subjects was twice that in young subjects (32 ± 6% vs. 16 ± 6% sem, P < 0.05) and was related to plasma CCK-8 concentrations, which were higher at baseline (P < 0.05) and increased more during CCK-8 infusions in older than young subjects (P < 0.01). The extent of suppression of food intake per given rise in plasma CCK-8 concentrations did not differ between the two age groups (P = 0.35). Endogenous CCK concentrations were higher at baseline in older subjects (P < 0.001) and decreased during the CCK-8 but not control infusions (P < 0.01), suggesting that CCK suppresses its own release. Plasma leptin concentrations were not affected by CCK infusion, whereas postprandial insulin concentrations were lowered and the peak postprandial glucose concentration was delayed but not affected by CCK-8 infusion. Because older people retain their sensitivity to the satiating effects of exogenous CCK and plasma endogenous CCK concentrations are higher in older people, increased CCK activity may contribute to the anorexia of aging.

scholarly journals Can welfare-rights advice targeted at older people reduce social exclusion?

2008 ◽  
Vol 28 (6) ◽  
pp. 875-899 ◽  
Author(s):  
SUZANNE MOFFATT ◽  
GRAHAM SCAMBLER
Keyword(s):  
Older People ◽  
Social Exclusion ◽  
Social Relations ◽  
Care Service ◽  
Health Care Service ◽  
Age Groups ◽  
Median Income ◽  
Welfare Rights ◽  
Welfare Benefits ◽  
The Impact

ABSTRACTIt is known that, in general, people of pensionable age have gained in income compared to other age groups in the British population over the last two decades, but that a substantial minority still experience relative poverty. This paper reports a small qualitative study into the effectiveness of a welfare-rights advice and acquisition service for men and women aged 60 or more years that was provided through a local primary health-care service. Additional financial and non-financial resources were obtained by accessing previously unclaimed state-welfare benefits. It was found that these significantly improved the participants' quality of life. Fourteen of the 25 participants received some type of financial award as a result of the service offered, with the median income gain being £57 (€84 or US $101) per week. The impact of additional resources was considerable and included: increased affordability of necessities and occasional expenses; increased capacity to cope with emergencies; and reduced stress related to financial worries. Knowledge of and access to welfare-rights services also appeared to have a positive effect. It is argued that a level of material resources above a basic level is necessary for social relations and for accessing services and civic activities, and can reduce social exclusion among older people.

EMPLOYMENT OF OLDER PEOPLE IN THE MODERN LABOR MARKET

2021 ◽  
pp. 409-418
Author(s):  
В.Ю. Бабышев ◽  
Г. А. Барышева
Keyword(s):  
Labor Market ◽  
Older People ◽  
Older Workers ◽  
Age Groups ◽  
Labor Legislation ◽  
Demographic Aging ◽  
Age Cohort ◽  
Working Age ◽  
Medical Advances ◽  
The Impact

В статье рассматривается занятость лиц пожилого возраста в условиях сорвеменных технологических, медицинских и демографических изменений. Актуальность темы исследования обусловлена демографическим старением населения, современными достижениями медицины и изменением характера трудовых операций в результате научно-технического прогресса. В данной статье проверены следующие конкурирующие гипотезы: производительность работников старших возрастных групп находится ниже уровня рентабельности из-за неуклонного ухудшения здоровья или, наоборот, ценность работников старших возрастных групп на современном рынке труда возрастает из-за повышения роли опыта, навыков и квалификации. Дополнительно проанализирован вопрос влияния систем пенсионного обеспечения на мотивацию лиц пожилого возраста к продолжению трудовой деятельности. Для проверки данных гипотез на основе статистики Организации экономического сотрудничества и развития проведен анализ общего уровня занятости, участия в рабочей силе и безработицы, а также временной и неполной занятости по нескольким возрастным группам в диапазоне 15-65 лет и старше. Для оценки динамики проанализирована ситуация на 2000 и 2019 гг. В целом сделан вывод, что количественные и качественные параметры занятости у работников старших возрастных групп уступают среднему рабочему возрасту, однако во временной динамике использование человеческого капитала лиц пожилого возраста растет. В области геронтологии рекомендовано уделять повышенное внимание улучшению здоровья возрастной когорты 65 лет и старше и изменению трудового законодательства в плане стимулирования продолжения трудовой деятельности после официального наступления пенсионного возраста. The article examines the employment of older people in the context of disrupted technological, medical and demographic changes. The relevance of the research topic is due to the demographic aging of the population, modern medical advances and changes in the nature of labor operations as a result of scientific and technological progress. In this article, the following competing hypotheses are tested: the productivity of older workers is below the level of profitability due to a steady decline in health, or vice versa, the value of older workers in the modern labor market is increasing due to the increasing role of experience, skills and qualifications. Additionally, the question of the impact of pension systems on the motivation of older people to continue working is analyzed. To test these hypotheses, based on OECD statistics, we analyzed the overall level of employment, labor force participation and unemployment, as well as temporary and underemployment for several age groups in the range of 15-65+ years. To assess the dynamics, the situation for 2000 and 2019 was analyzed. In general, the author concludes that the quantitative and qualitative parameters of employment of older people are inferior to the average working age, but over time, the use of the human capital of older people is growing. In the field of gerontology, it is recommended to pay increased attention to improving the health of the 65+ age cohort and changing labor legislation in order to stimulate the continuation of work.

Interleukin-2 Transiently Inhibits Pulsatile Growth Hormone Secretion in Young but not Older Healthy Men

2021 ◽  
Author(s):  
Ferdinand Roelfsema ◽  
Rebecca Yang ◽  
Johannes D Veldhuis
Keyword(s):  
Hormone Secretion ◽  
Interleukin 2 ◽  
Age Groups ◽  
Growth Hormone Secretion ◽  
Experimental Conditions ◽  
Deconvolution Analysis ◽  
Healthy Men ◽  
Gh Secretion ◽  
Older Subjects ◽  
Young Subjects

Abstract Context Interleukin-2 (IL2), a proinflammatory cytokine, has been used to treat malignancies. Increased cortisol and ACTH were noted, but GH secretion was not investigated in detail. Objective We quantified GH secretion after a single sc injection of IL2 in 17 young and 18 older healthy men in relation to dose, age and body composition. Design This was a placebo-controlled, blinded, prospectively randomized cross-over study. At 20:00 h IL2 (3 or 6 million units per m2 ) or saline was injected sc. Lights were off between 23:00 and 07:00 h. Blood was sampled at 10-min intervals for 24 h. Outcome measures Deconvolution analysis of GH secretion. Results GH profiles were pulsatile under both experimental conditions and lower in older than young volunteers. Since the effect of IL2 might be time-limited, GH analyses were performed on the complete 24-h series and the 6 h after IL2 administration. Total and pulsatile 24-h GH secretion decreased nonsignificantly. Pulsatile secretion fell over the first 6 h after IL2 (P=0.034), with visceral fat as covariate (P=0.003), but not age(P=0.10). Plots of cumulative 2-h bins of GH pulse mass showed a distinction by treatment and age groups: a temporary GH decrease of 32% and 28% occurred in the first 2-h bins after midnight (P=0.019 and 0.038) in young subjects, while in older subjects no differences were present at any time point. Conclusion This study demonstrates that IL2 temporarily diminishes GH secretion in young, but not elderly, men.

Reduced epinephrine clearance and glycemic sensitivity to epinephrine in older individuals

1998 ◽  
Vol 275 (5) ◽  
pp. E770-E776 ◽  
Author(s):  
James C. Marker ◽  
William E. Clutter ◽  
Philip E. Cryer
Keyword(s):  
Sedentary Lifestyle ◽  
Plasma Norepinephrine ◽  
Older Individuals ◽  
Plasma Epinephrine ◽  
Response Curves ◽  
Older Subjects ◽  
Young Subjects ◽  
Cellular Responsiveness ◽  
The Impact ◽  
Epinephrine Concentration

To test the hypothesis that glycemic sensitivity to epinephrine is reduced in older individuals and to assess the impact of a sedentary lifestyle on responses to the hormone, we performed 30-min sequential intravenous infusions of epinephrine (0, 41, 82, 164, 246, and 328 pmol ⋅ kg−1⋅ min−1) in young ( n = 10) and older ( n = 23) healthy subjects. We performed these again after 12 mo of physical training, which raised peak O2consumption from 24.4 ± 1.0 to 30.4 ± 1.4 ml ⋅ kg−1⋅ min−1( P < 0.01) in most of the older subjects ( n = 21). During epinephrine infusions, plasma epinephrine concentrations were higher ( P = 0.0001) in older than in young subjects (e.g., final values of 7,280 ± 500 vs. 4,560 ± 380 pmol/l, respectively), indicating that the clearance of epinephrine from the circulation was reduced in the older individuals. Plasma epinephrine concentration-response curves disclosed reduced glycemic sensitivity to the hormone in the older subjects ( P = 0.0001), a finding plausibly attributed to increased sympathetic neural activity, as evidenced here by higher plasma norepinephrine concentrations ( P = 0.0001) in the older subjects and consequent desensitization of cellular responsiveness to catecholamines. Training did not correct reduced epinephrine clearance, reduced glycemic sensitivity to epinephrine, or raised norepinephrine levels. We conclude that aging is associated with reduced clearance of epinephrine from the circulation and reduced glycemic sensitivity to epinephrine, the latter plausibly attributed to an age-associated increase in sympathetic neural norepinephrine release. These age-associated changes are not the result of a sedentary lifestyle.

scholarly journals THE IMPACT OF LIFESTYLE BEHAVIORS ON HEALTHY AGING TRAJECTORIES: THE ATHLOS PROJECT

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S799-S800
Author(s):  
Christina Daskalopoulou ◽  
Yu-Tzu Wu ◽  
Artemis Koukounari ◽  
Graciela Muniz Terrera ◽  
Stefanos Tyrovolas ◽  
...  
Keyword(s):  
Older People ◽  
Healthy Aging ◽  
Healthy Lifestyle ◽  
Lifestyle Behaviors ◽  
Lifestyle Behaviours ◽  
Growth Mixture ◽  
Growth Mixture Modelling ◽  
Aging Study ◽  
Multilevel Item Response Theory ◽  
The Impact

Abstract The number of people above 60 years old will double by 2050. There is a considerate variability in the health status of older people. The identification of the different trajectories that people follow as they grow older constitutes one of the aims of the ATHLOS project. In the current study, we created a metric of health in the four available waves (2001, 2003, 2012, 2015) of the Mexican Health and Aging Study (MHAS) by employing Bayesian multilevel Item Response Theory. Growth mixture modelling indicated that older Mexicans (n=14,143) age by following four distinct pathways (i.e. high-stable, moderate-stable, low-stable, decliners). Adherence to healthy lifestyle behaviours (i.e. physical activity, non-smoking, limited alcohol consumption) was associated with better health trajectories. Preliminary analyses in the ATHLOS harmonised dataset also suggest that older people age by following four distinct pathways. The impact of lifestyle behaviours within the harmonised dataset will be investigated and also presented.

scholarly journals The Effect Of Display Brightness On Visual Function For Young And Old Drivers

2021 ◽  
Vol 1202 (1) ◽  
pp. 012036
Author(s):  
Gatis Ikaunieks ◽  
Gunta Krumina ◽  
Liva Volberga ◽  
Lauris Naumovs
Keyword(s):  
Visual Function ◽  
Age Groups ◽  
Luminance Level ◽  
Outdoor Advertising ◽  
Lighting Conditions ◽  
Discomfort Glare ◽  
Disability Glare ◽  
Older Subjects ◽  
Young Subjects ◽  
Method Of Adjustment

Abstract Nowadays outdoor advertising displays have become popular. Bright displays near the roads could cause drivers to experience disability or discomfort glare, especially at night. Disability glare increases with age, but discomfort glare thresholds are independent of age. The aim of the study was to assess a luminance level of displays, which causes glare for younger and older subjects. 24 young subjects age of 20 to 24 years and 13 older subjects age of 55 to 69 years participated in the study. The task was by using the method of adjustment to find out the acceptable level of display brightness when the recognition of high (>90%) contrast objects was comfortable. Measurements were done in a photopic and mesopic lighting conditions. Results showed that discomfort glare were larger in mesopic than in photopic lighting conditions (p < 0.001) for both age groups. Preferred display brightness in both lighting conditions did not significantly differ between age groups (p > 0.05). We can conclude that discomfort glare thresholds for displays with textual elements are independent of age.

Transport resources, mobility and unmet transport needs in old age

2012 ◽  
Vol 33 (7) ◽  
pp. 1190-1211 ◽  
Author(s):  
RANDI HJORTHOL
Keyword(s):  
Older People ◽  
Qualitative Data ◽  
Age Groups ◽  
Life Quality ◽  
Nationwide Survey ◽  
Small Samples ◽  
Private And Public ◽  
The Impact ◽  
The Empirical Analysis

ABSTRACTPrevious research has shown that mobility and the ability to leave the home are among the essential aspects of older people's quality of life. However, surveys of older people's access to transport resources and the impact of mobility on welfare and wellbeing are few. Many previous studies are based on small samples or qualitative data. The questions addressed in this paper are how transport resources are distributed among different groups of older people, to which degree the transport needs of these groups are met and how this is related to their wellbeing. The empirical analysis is based on a Norwegian nationwide survey among 4,723 respondents 65 years and older. The respondents were asked about their access to transport resources, both private and public, health problems connected to use of transport modes, their daily activities and mobility, their uncovered transport needs and the importance of different activities for their life quality. The analysis reveals great differences between groups; especially between men and women, but also between different age groups and by different place of living. The special transport offered by the local authorities is seen as insufficient, and with increasing age a great deal of older people have low mobility and an uncovered transport need that reduces their life quality.

scholarly journals Is Bullying Victimization in Childhood Associated With Mental Health in Old Age

2019 ◽  
Vol 76 (1) ◽  
pp. 161-172
Author(s):  
Bo Hu
Keyword(s):  
Mental Health ◽  
Older People ◽  
Old Age ◽  
Healthy Aging ◽  
Unobserved Heterogeneity ◽  
Age Groups ◽  
Later Life ◽  
Substantial Contribution ◽  
Bullying Victimization ◽  
Negative Impacts

Abstract Objective This study investigates the relationship between bullying victimization in childhood and mental health in old age. Methods The study uses data from a nationally representative sample of 9,208 older people aged 60 and older collected through the China Health and Retirement Longitudinal Study (CHARLS) conducted in 2014 and 2015. Results Older people who were bullied in childhood have more severe depressive symptoms and are more likely to be dissatisfied with life than those without the experience of bullying victimization. The negative impacts remain significant after childhood confounders (15 types of familial adversities), four groups of contemporary confounders (demographic, health, social support, and socioeconomic factors), and community-level unobserved heterogeneity are all controlled for. The negative impacts of bullying victimization on mental health are attenuated among people in very old age, which confirms the socioemotional selectivity theory. Discussion The consequences of bullying victimization for mental health are comparable to, or even greater than those of familial adversities and contemporary risk factors. The factors threatening mental health vary considerably for older people in different age groups. Effective anti-bullying schemes in childhood and personalized support in later life can make a substantial contribution to healthy aging.

Are social media users more satisfied with their life than non-users? A study on older Italians

2021 ◽  
pp. 1-13
Author(s):  
Emanuela Sala ◽  
Gabriele Cerati ◽  
Alessandra Gaia
Keyword(s):  
Social Media ◽  
Life Satisfaction ◽  
Older People ◽  
Age Groups ◽  
Household Survey ◽  
Active Ageing ◽  
Ageing Population ◽  
Italian Case ◽  
Use Of Social Media ◽  
The Impact

Abstract Despite older people's increasing use of social media (SM), there is relatively little research investigating the impact of SM use on wellbeing in the ageing population. This study investigates the relationship between SM use and life satisfaction, a key dimension of wellbeing, in three age groups. We focus on the Italian case, which is particularly relevant because Italy is one of the countries both with the highest incidence of older people and the lowest uptake of SM in Europe. Applying linear regression modelling techniques, we analyse data from the 2018 Multipurpose Survey – Aspects of Everyday Living, a large probability-based household survey. For two age groups, we find a positive relationship between SM use and life satisfaction which weakens after controlling for older people's demographic and socio-economic characteristics, health conditions and social network characteristics. Given the grey digital divide that still exists in some European countries, we conclude with a call for urgent interventions to remove the hurdles that prevent frail older people from enjoying the benefits of an active ageing, fully exploiting the potential of SM use.

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