scholarly journals Papillary Thyroid Carcinoma Within Thyroglossal Duct Cyst

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A895-A896
Author(s):  
Raghda Al Anbari ◽  
Majlinda Xhikola ◽  
Sushma Kadiyala
Keyword(s):  
Thyroid Gland ◽  
Total Thyroidectomy ◽  
Thyroid Cartilage ◽  
Thyroid Tissue ◽  
Neck Mass ◽  
Thyroglossal Duct Cyst ◽  
Papillary Thyroid ◽  
Anterior Neck ◽  
Duct Cyst ◽  
Thyroglossal Duct

Abstract A 55-year-old female with medical history of hypothyroidism and fibrocystic disease of the breast presented with complains of a painful anterior neck mass, difficulty swallowing and hoarseness of the voice. Symptoms had progressed over a period of 5 months. CT neck with contrast indicated the presence of an ectopic thyroid tissue anterior to the thyroid cartilage measuring approximately 1.7 x 1.2 x 3.1 cm, with indistinct inferior margins and internal calcifications. The hyoid bone or thyroid cartilage had no irregularities. The thyroid gland itself was unremarkable except for small complex thyroid nodules in both lobes. No masses within the pharynx or larynx were noted. Family history was significant for lymphoma in her father. On physical exam, a hard, mobile right anterior neck mass was appreciated. Labs showed normal TSH of 1.05 uIU/mL and normal free T4 of 1.2 ng/dL. Further evaluation with a dedicated neck US showed a right submandibular mass, superior to the thyroid, lobulated and heterogeneous measuring 2.0 x 1.0 x 2.3 cm with multiple areas of calcifications and internal Doppler flow. The thyroid gland had normal size and texture with bilateral sub centimeter non-concerning nodules. After ENT evaluation and an unremarkable flexible fiberoptic nasolaryngoscope, patient underwent surgical excisional biopsy of the neck mass. Pathology was consistent with thyroglossal duct cyst with the presence of thyroid follicles. An incidental finding of a 0.9 cm papillary microcarcinoma was noted, which was encapsulated with focal extracapsular follicular structures showing papillary nuclear features with no perineural or lymphovascular invasion. The tumor cells were immunoreactive for TTF-1 and PAX8. Development of papillary thyroid cancer within the thyroglossal duct cyst is a rare event, reportedly occurring in 1% of thyroglossal duct cysts. There are no well-established management guidelines. Current management strategies consist of monitoring with serial neck ultrasound versus total thyroidectomy with consideration of postsurgical I-131 treatment, based on pathology results. Our patient opted for undergoing total thyroidectomy.

scholarly journals Papillary Carcinoma Occurrence in a Thyroglossal Duct Cyst with Synchronous Papillary Thyroid Carcinoma without Cervical Lymph Node Metastasis: Two-Cases Report

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
F. B. Sobri ◽  
M. Ramli ◽  
U. N. Sari ◽  
M. Umar ◽  
D. K. Mudrick
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Total Thyroidectomy ◽  
Neck Mass ◽  
Thyroglossal Duct Cyst ◽  
Papillary Thyroid ◽  
Duct Cyst ◽  
Palpable Mass ◽  
Thyroglossal Duct ◽  
Sistrunk Procedure

Background.We present two rare cases of papillary carcinomas which appeared in thyroglossal duct cysts. These cases highlight that thyroglossal duct cyst can serve as malignancy of thyroid gland.Methods.A retrospective case report was carried out on 2 patients at Cipto Mangunkusumo Hospital.Results.A 57-year-old man presented with enlarged right anterior and midline neck mass, which preoperatively were diagnosed as thyroglossal duct cyst (TDC) and nontoxic multinodular goiter. A total thyroidectomy and Sistrunk procedure were performed. In the second case, a 35-year-old woman presented with a lump which occurred at anterior neck region without palpable mass at the thyroid. Preoperatively, it was diagnosed as TDC. Sistrunk procedure was performed, followed by total thyroidectomy a month after the first operation. Histopathology showed papillary thyroid carcinoma in both patients.Conclusion.The occurrence of carcinoma in TDC is very rare but should always be considered as an option in making diagnosis for a neck mass.

scholarly journals Thyroglossal Duct Cyst Papillary Carcinoma With Airway Compromise

2021 ◽  
pp. 014556132110220
Author(s):  
Po-Kai Huang ◽  
Li-Chun Hsieh ◽  
Yi-Shing Leu
Keyword(s):  
Symptom Relief ◽  
Thyroid Tissue ◽  
Neck Mass ◽  
Thyroglossal Duct Cyst ◽  
Ectopic Thyroid ◽  
Airway Compromise ◽  
Duct Cyst ◽  
Complete Excision ◽  
Thyroglossal Duct ◽  
Ectopic Thyroid Tissue

Thyroglossal duct cysts are typically benign and usually asymptomatic. Malignant transformation is uncommon. Intralaryngeal extension is rare and results in dysphonia or dyspnea. There is no literature nowadays reporting the thyroglossal duct cyst carcinoma combining the clinical features of intralaryngeal extension. The authors present a case of progressive hoarseness and midline neck mass for 2 years. The laryngoscope and computed tomography revealed a 6-cm thyroglossal duct cyst containing ectopic thyroid tissue with intralaryngeal extension and causing airway obstruction. Complete excision with Sistrunk operation revealed papillary thyroid carcinoma. The patient resumed normal phonation after the surgery. There was no evidence of tumor recurrence and no hoarseness or dyspnea at 6 months follow up. This is the first reported case of a huge thyroglossal duct cyst carcinoma with intralaryngeal extension causing airway compromise. Complete excision of tumor is essential and vital to the symptom relief. A thyroglossal duct cyst carcinoma with endolaryngeal involvement should be considered in the differential diagnosis when the case has a massive midline neck mass with ectopic thyroid tissue and develops dyspnea or hoarseness concurrently.

Simultaneous occurrence of a thyroglossal duct cyst and a lingual thyroid in the absence of an orthotopic thyroid gland

2011 ◽  
Vol 126 (2) ◽  
pp. 217-220 ◽  
Author(s):  
J Madana ◽  
R Kalaiarasi ◽  
D Yolmo ◽  
S Gopalakrishnan
Keyword(s):  
Thyroid Gland ◽  
English Language ◽  
Thyroid Tissue ◽  
Clinical Findings ◽  
Thyroglossal Duct Cyst ◽  
Simultaneous Occurrence ◽  
Lingual Thyroid ◽  
Duct Cyst ◽  
Thyroglossal Duct ◽  
Thyroglossal Duct Cysts

AbstractObjective:We report an extremely rare case of the simultaneous occurrence of a thyroglossal duct cyst and a lingual thyroid in the absence of an orthotopic thyroid gland, in a seven-year-old girl from South India.Method:Case report and a review of the English language literature on the subject.Results:The patient presented with a mass on the tongue that had been present for three years, and an anterior neck swelling that had been present for two years. Examination revealed a midline, pinkish, firm mass present on the posterior one-third of the tongue. The neck showed a midline cystic swelling in the infrahyoid position. Radiological imaging confirmed the clinical findings, revealing the absence of her thyroid gland in the normal location. Sistrunk's procedure was performed leaving behind a lingual thyroid. At 13-month follow up, the patient was euthyroid with no recurrence.Conclusion:To our knowledge the association of a lingual thyroid and a thyroglossal cyst has only been reported once in the literature. The presence of a lingual thyroid in the absence of a normally located thyroid gland or functioning thyroid tissue along the thyroglossal tract, confirmed by radionuclide and computed tomography imaging, may indicate the failure of the normal descent of the thyroid gland during embryonic development. This probable absence of the descent of the thyroid raises questions regarding the origin of thyroglossal duct cysts.

Thyroglossal Duct Cyst Causing Airway Obstruction in an Adult

1996 ◽  
Vol 75 (8) ◽  
pp. 530-534 ◽  
Author(s):  
Eugene G. Brown ◽  
Marcus S. Albernaz ◽  
Mark T. Emery
Keyword(s):  
Airway Obstruction ◽  
English Language ◽  
Neck Mass ◽  
Thyroglossal Duct Cyst ◽  
Airway Compromise ◽  
Anterior Neck ◽  
Duct Cyst ◽  
Cervical Mass ◽  
Thyroglossal Duct ◽  
Thyroglossal Duct Cysts

Thyroglossal duct cysts, though not uncommon, rarely present with evidence of laryngeal compromise. The case presented is one of the very few cases with documented laryngeal invasion reported in the English language. Of clinical significance is the patient's presentation with laryngeal symptoms of choking and dysphonia in the presence of a small anterior cervical mass. While the thyroglossal duct cyst usually presents as an asymptomatic anterior neck mass, this case illustrates the importance of considering a thyroglossal duct cyst in any patient with airway compromise in the absence of a neck mass.

scholarly journals Concurrent Papillary Carcinoma of Thyroglossal Duct Cyst and Thyroid Isthmus, Beyond the Sistrunk Procedure

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A888-A888
Author(s):  
Aiman Riaz ◽  
Aysha Khan ◽  
Azad Jabiev ◽  
Ibitoro Nnenna Osakwe
Keyword(s):  
Lymph Node ◽  
Total Thyroidectomy ◽  
Central Compartment ◽  
Thyroglossal Duct Cyst ◽  
Braf V600e ◽  
Papillary Thyroid ◽  
Thyroglossal Cyst ◽  
Duct Cyst ◽  
Thyroglossal Duct ◽  
Sistrunk’S Procedure

Abstract Introduction/Background: Papillary carcinoma (PC) originating from the thyroglossal cyst is a rare entity. It is even more uncommon to have concurrent thyroglossal duct cyst PC and papillary thyroid carcinomas (PTC). The surgical approach for such patients would involve a combination of a Sistrunk’s procedure and total thyroidectomy. We describe management of a patient found to have multi focal PC originating from a thyroglossal duct cyst and thyroid isthmus with extensive cervical lymph node metastasis. Clinical Case: 30-year-old male presented to PCP with palpable bilateral cervical adenopathy most prominent in the right supraclavicular region. Neck ultrasound confirmed multiple metastatic appearing nodes (largest 4cm) in the central, right and left lateral cervical compartments as well as a hypoechoic, TI-RADS category 5 right thyroid isthmus nodule. FNA of the cervical nodes confirmed metastatic PTC. Neck CT in addition to extensive cervical adenopathy revealed a 2 cm solid mass inferior to the central hyoid bone with infiltrative borders and calcifications suspicious for a primary tumor. Patient underwent total thyroidectomy with central compartment lymph node dissection, excision of thyroglossal cyst and bilateral modified radical neck dissections. Histopathology report revealed a 2.4 cm thyroglossal duct tumor and a 1.1 cm tumor in the thyroid isthmus, confirming two separate tumors both being classical variants of papillary thyroid carcinoma, with no lympho-vascular invasion and 8/53 positive lymph nodes. BRAF V600E mutation was positive. On follow up, the patient is doing well and has deferred adjuvant radioactive iodine treatment for 6 months for personal reasons. Clinical Lesson/ Conclusion: PC of the thyroglossal cyst with synchronous isthmic PTC merits total thyroidectomy and central compartment dissection in addition to the Sistrunk’s procedure, as the likelihood of local metastasis is high. Presence of BRAF V600E mutation has been identified as a predictor of more aggressive behavior in isolated PC of the thyroglossal duct cyst, suggesting a need for more than a Sistrunk’s procedure in such patients. Our patient, who presented with local lymph node metastasis supports this conclusion. Determining BRAF mutation status preoperatively may be a helpful strategy in planning the extent of surgery. Keywords Thyroglossal duct cyst, Papillary thyroid carcinoma, BRAF mutation

scholarly journals Ectopic Papillary Carcinoma in the Midline Neck Accompanied by a Benign Thyroid Gland

2019 ◽  
Vol 2019 ◽  
pp. 1-3
Author(s):  
Lauran Evans ◽  
SeHoon Park ◽  
Christie Elliott ◽  
Courtney Garrett
Keyword(s):  
Thyroid Gland ◽  
Unusual Case ◽  
Thyroid Tissue ◽  
Thyroglossal Duct Cyst ◽  
The Body ◽  
Ectopic Thyroid ◽  
Duct Cyst ◽  
Thyroglossal Duct ◽  
Ectopic Thyroid Tissue ◽  
Benign Thyroid

Ectopic thyroid tissue can deposit anywhere in the body. There are several cases reporting papillary thyroid carcinoma (PTC) arising from ectopic tissues; however, these cases largely presented with primary PTC within the native thyroid gland as well. Alternatively, some cases report of PTC found solely in an ectopic thyroglossal duct cyst, but reports of isolated malignancy in other types of ectopic thyroid tissue with normal native tissue are sparse throughout the literature. Here, we present an unusual case of PTC in the midline anterior neck that does not appear to be consistent with a thyroglossal duct cyst, accompanied by a completely benign native thyroid gland, of which only few cases have been reported.

scholarly journals Thyroglossal duct cyst masquerading as a laryngocele

2019 ◽  
Vol 12 (3) ◽  
pp. e228319 ◽  
Author(s):  
Renee Booth ◽  
Ashwini Milind Tilak ◽  
Sugoto Mukherjee ◽  
James Daniero
Keyword(s):  
Thyroid Cartilage ◽  
Thyroid Tissue ◽  
Operative Management ◽  
Paediatric Population ◽  
Neck Mass ◽  
Cystic Mass ◽  
Careful Consideration ◽  
Duct Cyst ◽  
Thyroglossal Duct ◽  
Preoperative Ct

Thyroglossal duct cysts (TGDCs) are the most common congenital neck mass and often present in the paediatric population as a painless mass in the midline. A lateralised neck mass presenting for the first time in an adult may raise more concern for malignancy or a laryngocele. A 50-year-old man presented with an asymptomatic right level II neck mass adjacent to the thyroid cartilage. Preoperative CT revealed a cystic mass right of the midline with an intralaryngeal component. Intraoperatively, the lesion tracked towards the central hyoid bone; a Sistrunk procedure was performed. Postoperative pathology revealed a small foci of thyroid tissue within the mass. Careful consideration of the origin of this unusually presenting TGDC enabled appropriate operative management.

scholarly journals Does Papillary Carcinoma of Thyroglossal Duct Cyst Develop De Novo?

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Tekin Baglam ◽  
Adem Binnetoglu ◽  
Ali Cemal Yumusakhuylu ◽  
Berat Demir ◽  
Gokce Askan ◽  
...  
Keyword(s):  
Thyroid Gland ◽  
Papillary Carcinoma ◽  
De Novo ◽  
Malignant Tumors ◽  
Thyroid Tissue ◽  
Thyroglossal Duct Cyst ◽  
Duct Cyst ◽  
Thyroglossal Duct ◽  
Thyroid Papillary ◽  
High Index Of Suspicion

Backround. Thyroglossal duct cyst (TDC) is a developmental abnormality of the thyroid gland. Due to embryological remnants of thyroid tissue located in the TDC, the same malignant tumors that develop in the thyroid gland can also develop in the TDC.Methods. We present the unique case of a 39-year-old female with simultaneous de novo papillary carcinoma in a TDC and the thyroid gland.Results. With the suspicion of simultaneous papillary carcinoma in the TDC and the thyroid gland, Sistrunk procedure with total thyroidectomy and central neck exploration was performed.Conclusion. The clinician should have a high index of suspicion upon encountering papillary carcinoma of the TDC to differentiate de novo papillary carcinoma in the TDC from those originating from the thyroid gland, because papillary carcinoma in TDC may originate from an occult thyroid papillary carcinoma.

scholarly journals Papillary Thyroid Carcinoma within Thyroglossal Duct Cyst: Case Series and Literature Review

2017 ◽  
Vol 22 (03) ◽  
pp. 253-255 ◽  
Author(s):  
Haissan Iftikhar ◽  
Mubasher Ikram ◽  
Karim Rizwan Nathani ◽  
Adnan Yar Muhammad
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Adult Population ◽  
Thyroid Tissue ◽  
Case Series ◽  
Thyroglossal Duct Cyst ◽  
Selective Neck Dissection ◽  
Papillary Thyroid ◽  
Duct Cyst ◽  
Thyroglossal Duct

Introduction Thyroglossal duct cyst (TGDC) is the most common congenital anomaly of the neck, and approximately 7% of all the adult population presents it. Ectopic thyroid tissue is found in the thyroglossal duct cyst wall in up to 65% of cases. This thyroid tissue has the potential to develop some type of malignancy, the most common of which is the papillary carcinoma of the thyroid. There are just over 270 cases of thyroglossal duct cyst malignancy reported in the literature. Objectives We aimed to study our population of patients in order to identify cases with thyroglossal duct cyst malignancy. Methods A retrospective chart review was conducted in the section of otolaryngology/head and neck surgery at a hospital in Karachi, Pakistan, from January of 2004 to December of 2014 on patients with the diagnosis of thyroglossal duct cyst. Results Fifty-eight patients were diagnosed with TGDC, two of whom also presented with thyroglossal duct cyst carcinoma. Both patients revealed papillary thyroid carcinoma on histopathology. Case 1 had an open biopsy before undergoing definitive surgery. Both patients underwent subsequent total thyroidectomy after Sistrunk procedure, and case 2 had selective neck dissection revealing lymph node metastasis. Conclusion Thyroglossal duct cyst carcinoma is a rare finding that comes as a surprise to both the patient and the surgeon. We report 2 out of 58 cases diagnosed with thyroglossal duct cyst carcinoma.

Sign in / Sign up

Export Citation Format

Share Document