scholarly journals Migraine phenotype prolongs recovery time in traumatic brain injury (TBI)

Neurology ◽  
2018 ◽  
Vol 91 (23 Supplement 1) ◽  
pp. S17.3-S18
Author(s):  
Cynthia Bennett-Brown ◽  
Sarah Ostrowski-Delahanty ◽  
Tracy Lynn Johnson ◽  
M. Cristina Victorio ◽  
Susan K. Klein

We proposed that children and adolescents who had headache of migraine phenotype at initial neurologic assessment after mild TBI would take longer to clear for return to play than those who did not have those headache characteristics. Additionally, we predicted that those with migraine phenotype would be more likely to have comorbid mood or cognitive symptoms, which would also contribute to prolonged recovery. To test this, we assessed all new patients for the presence or absence of migraine phenotype with the Three-Item ID migraine screener (Lipton et al. 2003) at the first outpatient visit. Over the 5 months follow up interval (October 2017–February 2018), office visit data for 121 patients (ages 0–19 years) showed that 61% presented initially with a migraine phenotype. In that interval, 48% % (N = 58) were cleared for return to play. Those with migraine phenotype headache took longer to clear (99 vs 71 days respectively, p = 0.004). Neither age nor gender made a significant impact on length of recovery when only the presence or absence of migraine phenotype alone was considered. If patients had a migraine (vs non-migraine) phenotype headache and comorbid cognitive or behavioral symptoms (38% in our sample), their time to recovery was prolonged (109 vs 74 days respectively; F (1, 56) = 7.215, p = 0.009). These data suggest that early identification of migraine phenotype in assessment of post-traumatic headache can lead to aggressive treatment of headache, thus shortening the interval of disability after TBI. Cognitive and behavioral symptoms seem to have additional impact on recovery and should be addressed and supported in rehabilitation.

2019 ◽  
Vol 7 (3_suppl) ◽  
pp. 2325967119S0013
Author(s):  
Natalya Sarkisova ◽  
Anita Herrera-Hamilton ◽  
Bianca Edison ◽  
Tracy Zaslow

Background: Recent literature has shown that between the two sexes, females sustain concussions at a higher rate than males. However, other studies have shown that males take a longer time recover after a concussion than females. Currently, there is limited research done on gender and recovery time in adolescents. Sex is defined as a biological concept that is assigned at birth whereas gender is defined as somebody’s internal self-identification. This study aims to determine if there is a difference in recovery time between genders. Methods: Patients diagnosed with a concussion in our sports medicine clinic were prospectively enrolled into a mild traumatic brain injury (mTBI) repository. 300 patient charts were reviewed. Age, non-binary gender identification, date of injury, first appointment date, and clearance date (Level V) were identified. Post-concussive syndrome (PCS) was also noted. Patients were also recognized if they were lost to follow up. Level of clearance was determined by the 4th International Conference on Concussion in Sports (Zurich 2012) with the following supervised protocol: Level 4: Non-contact training drills, Level 5: Full contact training after medical clearance. Results: 60% (180/300) of patients were cleared for return to play. 57% (171/180) of patients were cleared for a Level V and 5% (9/180) patients were cleared for a Level IV with gradual return to play. 120 (40%) patients were lost to follow up and not cleared, 60% (73/120) identified as male and 40% (47/120) identified as female. For the patients that were cleared, 67% (121/180) of patients identified as male (mean age=13 years) (range 5 to 18 years) and 33% (59/180) of patients identified as female (mean age=14 years) (range 5 to 20 years). From date of injury to recovery time, male patients were cleared on average after 62 days and female patients were cleared on average after 82 days. There was no significant difference between the two genders identified in this specific population (p=0.17). 14% of females and 15% of males were diagnosed with PCS. From date of injury to first appointment with a physician, male and female patients reported going an average 17 days post injury, with no significant difference (p=0.53). Conclusion: Rate of recovery time for patients that sustained a concussion showed no significant difference among genders. Further research is necessary for a comprehensive review of all genders to identify recovery time and appropriate treatment management.


2021 ◽  
Vol 9 (7_suppl3) ◽  
pp. 2325967121S0007
Author(s):  
Ranbir Ahluwalia ◽  
Scott Miller ◽  
Fakhry M. Dawoud ◽  
Jose O. Malave ◽  
Heidi Tyson ◽  
...  

Background: Vestibular dysfunction, characterized by nausea, dizziness, imbalance and/or gait disturbance, represents an important sport-related concussion (SRC) subtype associated with prolonged recovery. Vestibular physiotherapy is important to promote recovery; however, the benefit of earlier therapy is unclear. Purpose: To determine if earlier vestibular therapy for young athletes with sport-related concussion is associated with earlier return-to-play (RTP), return-to-learn (RTL), and symptom resolution. Study Design: Retrospective Cohort Study Methods: Patients ages 5-23 with sport-related concussion who initiated vestibular therapy from 1/2019-12/2019 were included and patient records were reviewed. Therapy initiation was defined as either early, ≤ 30 days post-injury, or late (>30 days). Univariate comparisons between groups, Kaplan-Meier plots and multivariate Cox proportional hazard modeling were performed. Results: Overall, 23 patients were included (10 early,13 late) aged 16.14±2.98 years and 43.5% male. There was no difference between group demographics or medical history. Median initial total and vestibular symptom scores were comparable between groups. The late therapy group required additional time to RTP (110[61.3,150.8] vs. 31[22.5, 74.5], 95% CI-115.0—8.0, p=0.028), but not to RTL (12[3.5,26.5] vs. 17.5[8,20.75], 95%CI -11.0-12.0, p=0.085. Most notably, the late therapy group required more time to achieve symptom resolution (121.5 days [71,222.8] vs. 54 days [27,91] 95%CI -150.0-9.0, p=0.018). Adjusting for age and initial total symptom score, earlier therapy was protective against delayed symptom resolution (HR 0.988, 95%CI 0.98-0.99, p=0.008). Conclusion: This pilot study evaluating vestibular therapy timing suggests that initiating VRT within the first 30 days following SRC is associated with earlier RTP and symptom resolution. Further prospective trials to evaluate if even earlier VRT to resolve post-concussion syndrome should be pursued. Tables/Figures: [Figure: see text]


2017 ◽  
Vol 1 (S1) ◽  
pp. 80-80
Author(s):  
Sarah Terry ◽  
Molly Cox ◽  
Alexandra Linley ◽  
Jilian O’Neill ◽  
Laura Dreer

OBJECTIVES/SPECIFIC AIMS: To characterize parent communication frequency and content between systems of care (medical, school, and sports/recreation) of concussed youth who are in prolonged recovery. METHODS/STUDY POPULATION: In this ongoing study, 16 concussed youth (average age=14.9 years, SD=1.5; 31.2% female and 68.8% male) and their parent study partner (average age=44.3 years, SD=4.3; 87.3% female and 12.5% male) have been enrolled to date from sports medicine clinics. Demographic information was obtained during the initial clinic intake session. Weekly phone calls were also conducted with the parent and child until the child was considered asymptomatic (ie, reporting no symptoms on the SCAT3), to collect data on communication with the school, sport/recreation, and medical systems throughout the recovery process. For the purpose of this study, we evaluated communication patterns of those parents who had a child in prolonged recovery (ie, symptomatic 14 d or more post-concussion injury). Communication variables included frequency (ie, number of times a parent contacted or attempted to contact a system of care) and content or topic discussed during the contact event. RESULTS/ANTICIPATED RESULTS: Of the 16 enrolled participants to date, 68.8% (n=11) experienced concussion related symptoms 14 days postinjury (M=22.2, SD=4.6) at the time of their 2 week follow-up call and were thus considered to be in prolonged recovery. Of those 11, 81.8% (n=9) of parents reported communicating with the school system at some point between the initial clinic intake session and the 2 week follow-up phone call. The frequency of communication for this period ranged between 0 and 10 instances of contact (M=2.5, SD=2.9). Of the 11 prolonged cases, 8 participants were members of sports teams. Sixty-three percent (n=5) of those parents with a child on a sports team communicated with a coach while none of the parents contacted a team athletic trainer. The frequency of communication with the coach ranged from 0 to 8 (M=1.5, SD=2.5) over the course of 2 weeks from enrollment. With regards to the medical system, the majority of parents (72.7%, n=8) communicated at least once with a medical professional during the same time period. The frequency of communication with the medical system ranged from 0 to 8 (M=2.2, SD=2.6) points of contact. Themes that arose for communicating with the school system included informing school personnel of academic accommodations prescribed by the physician, explaining absences, and concerns about missed academic work and grades. The content of communication with the sports system (ie, coach) pertained to return-to-play issues as well as progress updates on recovery. Themes for communication with the medical system were centered on scheduling appointments, attending follow-up medical appointments, and starting return-to-play protocols. DISCUSSION/SIGNIFICANCE OF IMPACT: Parents of concussed youth who were still in prolonged recovery, for the most part, appear engaged in communicating with multiple systems of care. However, a subset of parents did not participate in contact with these systems. Further discussion of these findings will highlight areas for improvement in concussion management as well as strategies parents can utilize to advocate for their child in terms of return-to-learn and recovery.


2021 ◽  
Vol 9 (7_suppl4) ◽  
pp. 2325967121S0020
Author(s):  
Michael Ryan ◽  
Benton Emblom ◽  
E. Lyle Cain ◽  
Jeffrey Dugas ◽  
Marcus Rothermich

Objectives: While numerous studies exist evaluating the short-term clinical outcomes for patients who underwent arthroscopy for osteochondritis dissecans (OCD) of the capitellum, literature on long-term clinical outcomes for a relatively high number of this subset of patients from a single institution is limited. We performed a retrospective analysis on all patients treated surgically for OCD of the capitellum at our institution from January 2001 to August 2018. Our hypothesis was that clinical outcomes for patients treated arthroscopically for OCD of the capitellum would be favorable, with improved subjective pain scores and acceptable return to play for these patients. Methods: Inclusion criteria for this study included the diagnosis and surgical treatment of OCD of the capitellum treated arthroscopically with greater than 2-year follow-up. Exclusion criteria included any surgical treatment on the ipsilateral elbow prior to the first elbow arthroscopy for OCD at our institution, a missing operative report, and/or any portions of the arthroscopic procedure that were done open. Follow-up was achieved over the phone by a single author using three questionnaires: American Shoulder and Elbow Surgeons – Elbow (ASES-E), Andrews/Carson KJOC, and our institution-specific return-to-play questionnaire. Results: After the inclusion and exclusion criteria were applied to our surgical database, our institution identified 101 patients eligible for this study. Of these patients, 3 were then excluded for incomplete operative reports, leaving 98 patients. Of those 98 patients, 81 were successfully contacted over the phone for an 82.7% follow-up rate. The average age for this group at arthroscopy was 15.2 years old and average post-operative time at follow-up was 8.2 years. Of the 81 patients, 74 had abrasion chondroplasty of the capitellar OCD lesion (91.4%) while the other 7 had minor debridement (8.6%). Of the 74 abrasion chondroplasties, 29 of those had microfracture, (39.2% of that subgroup and 35.8% of the entire inclusion group). Of the microfracture group, 4 also had an intraarticular, iliac crest, mesenchymal stem-cell injection into the elbow (13.7% of capitellar microfractures, 5.4% of abrasion chondroplasties, and 4.9% of the inclusion group overall). Additional arthroscopic procedures included osteophyte debridement, minor synovectomies, capsular releases, manipulation under anesthesia, and plica excisions. Nine patients had subsequent revision arthroscopy (11.1% failure rate, 5 of which were at our institution and 4 of which were elsewhere). There were also 3 patients within the inclusion group that had ulnar collateral ligament reconstruction/repair (3.7%, 1 of which was done at our institution and the other 2 elsewhere). Lastly, 3 patients had shoulder operations on the ipsilateral extremity (3.7%, 1 operation done at our institution and the other 2 elsewhere). To control for confounding variables, scores for the questionnaires were assessed only for patients with no other surgeries on the operative arm following arthroscopy (66 patients). This group had an adjusted average follow-up of 7.9 years. For the ASES-E questionnaire, the difference between the average of the ASES-E function scores for the right and the left was 0.87 out of a maximum of 36. ASES-E pain was an average of 2.37 out of a max pain scale of 50 and surgical satisfaction was an average of 9.5 out of 10. The average Andrews/Carson score out of a 100 was 91.5 and the average KJOC score was 90.5 out of 100. Additionally, out of the 64 patients evaluated who played sports at the time of their arthroscopy, 3 ceased athletic participation due to limitations of the elbow. Conclusions: In conclusion, this study demonstrated an excellent return-to-play rate and comparable subjective long-term questionnaire scores with a 11.1% failure rate following arthroscopy for OCD of the capitellum. Further statistical analysis is needed for additional comparisons, including return-to-play between different sports, outcome comparisons between different surgical techniques performed during the arthroscopies, and to what degree the size of the lesion, number of loose bodies removed or other associated comorbidities can influence long-term clinical outcomes.


2021 ◽  
Vol 29 (1) ◽  
pp. 230949902199799
Author(s):  
Tianming Yu ◽  
Jichong Ying ◽  
Jianlei Liu ◽  
Dichao Huang ◽  
Hailin Yan ◽  
...  

Purpose: The study described a novel surgical treatment of Haraguchi type 1 posterior malleolar fracture in tri-malleolar fracture and patient outcomes at intermediate period follow-up. Methods: All patients from January 2015 to December 2017 with tri-malleolar fracture of which posterior malleolar fractures were Haraguchi type 1, were surgically treated in this prospective study. Lateral and medial malleolar fractures were managed by open reduction and internal fixation through dual incision approaches. 36 cases of Haraguchi type 1 posterior malleolar fractures were randomly performed by percutaneous posteroanterior screw fixation with the aid of medial exposure (group 1). And 40 cases were performed by percutaneous anteroposterior screw fixation (group 2). Clinical outcomes, radiographic outcomes and patient-reported outcomes were recorded. Results: Seventy-six patients with mean follow-up of 30 months were included. There were no significant differences in the mean operation time (81.0 ± 11.3 vs. 77.2 ± 12.4), ankle function at different periods of follow-up, range of motions and visual analog scale (VAS) at 24 months between the two groups ( p > 0.05). However, the rate of severe post-traumatic arthritis (Grade 2 and 3) and the rate of step-off rather than gap in radiological evaluation were lower in group 1 than that in group 2 ( p < 0.05). Conclusion: Using our surgical technique, more patients had good outcome with a lower rate of severe post-traumatic arthritis, compared with the group of percutaneous anteroposterior screw fixation. Percutaneous posteroanterior screw fixation can be a convenient and reliable alternative in treating Haraguchi type 1 posterior malleolar fracture.


2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
A Pio-Abreu ◽  
F Trani-Ferreira ◽  
G.V Silva ◽  
L.A Bortolotto ◽  
L Drager

Abstract Background Resistant (HR) and refractory hypertension (HRef) are associated with increased cardiovascular events and target-organ damage. However, appropriate HR and HRef diagnosis require good drug adherence. In this context, the “gold standard” method for assessing adherence is supervised medication intake. However, it is not clear the real utility of supervised medication intake in clinical practice. Purpose To evaluate whether hospitalization for confirming anti-hypertensive adherence in patients with HR and HRef may impact blood pressure (BP) control after hospital discharge in patients with HR or HRef suspicious at a tertiary outpatient clinic. Methods We recruited consecutive patients with HR or HRef suspicious admitted to the Hospital for confirming treatment adherence. HR was defined as uncontrolled office BP (≥140 and/or ≥90mmHg) despite using ≥3 classes at optimal doses (one of them being diuretic) or controlled BP using ≥4 classes. HRef was defined as no BP control despite using ≥5 antihypertensive drugs. Patients with suspected HRef who did not meet the criteria but full field the HR definition were named HRNoRef. During hospitalization, all patients used low sodium diet and had supervised taking of prescribed drugs by the medical team aiming BP control. We defined not only the rate of adherence and HF/HRef status but also BP and number of antihypertensive drugs at hospital discharge and in the two first return outpatient's visits. Results We studied a total of 83 patients with suspected HR/HRef (age 53±14 years; 76% females; pre-hospitalization systolic and diastolic BP: 177±28 and 106±21mmHg, respectively). Of these, 68.7% (57 patients) had suspected HRef in the outpatient clinic. The average number of antihypertensive drugs on admission was 5.3±1.3 classes. After hospitalization, the overall frequency of HR fell to 80% (66 patients). The average number of antihypertensive drugs at hospital discharge as well as systolic and diastolic BP was 4.5±1.3 classes, 131±17mmHg and 80±12mmHg, respectively (p&lt;0.001 vs. pre-hospitalization for all comparisons). Among the HR types, HRef was confirmed in only 27 patients (32.5%). During the outpatient follow-up, the patients remained with lower number of antihypertensive drugs as well as lower systolic and diastolic BP at first outpatient visit (mean returned time: 2.1±1.7months) and second outpatient visit post-discharge (mean returned time 7.1±2.6months) as compared to pre-hospitalization data: First visit: 4.3±1.2 classes, systolic: 152±24mmHg, diastolic BP: 89±17mmHg; second visit: 4.5±1.3 classes, systolic: 150±26mmHg, diastolic BP: 89±15mmHg; (p&lt;0.001 vs. pre-hospitalization for all comparisons). Conclusion Supervised medication intake during hospitalization may help not only to define the HR and HRef status but also to have impact on the number of antihypertensive drugs and lower BP values at short and mid-term follow-up. Funding Acknowledgement Type of funding source: None


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Masato Nagai ◽  
Tetsuya Ohira ◽  
Masaharu Maeda ◽  
Seiji Yasumura ◽  
Itaru Miura ◽  
...  

AbstractPost-traumatic stress disorder (PTSD) and obesity share common risk factors; however, the effect of obesity on recovery from PTSD has not been assessed. We examined the association between body mass index (BMI) and recovery from PTSD after the Great East Japan Earthquake. We analyzed 4356 men and women with probable PTSD aged ≥ 16 years who were living in evacuation zones owing to the radiation accident in Fukushima, Japan. Recovery from probable PTSD was defined as Post-traumatic Stress Disorder Checklist-specific scores < 44. Using Poisson regression with robust error variance adjusted for confounders, we compared the prevalence ratios (PRs) and 95% confidence intervals (CIs) for this outcome in 2013 and 2014. Compared with point estimates for normal weight (BMI: 18.5–24.9 kg/m2), especially in 2013, those for underweight (BMI: < 18.5 kg/m2) and obesity (BMI: ≥ 30.0 kg/m2) tended to slightly increase and decrease, respectively, for recovery from probable PTSD. The multivariate-adjusted PRs (95% CIs) for underweight and obesity were 1.08 (0.88–1.33) and 0.85 (0.68–1.06), respectively, in 2013 and 1.02 (0.82–1.26) and 0.87 (0.69–1.09), respectively, in 2014. The results of the present study showed that obesity may be a useful predictor for probable PTSD recovery. Obese victims with PTSD would require more intensive support and careful follow-up for recovery.


2011 ◽  
Vol 39 (1) ◽  
pp. 79-83 ◽  
Author(s):  
J. A. Llompart-Pou ◽  
J. M. Abadal ◽  
J. Pérez-bárcena ◽  
M. Molina ◽  
M. Brell ◽  
...  

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