Intracerebral hemorrhage location and outcome among INTERACT2 participants

Objective:To clarify associations between intracerebral hemorrhage (ICH) location and clinical outcomes among participants of the main phase Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT2).Methods:Associations between ICH sites and poor outcomes (death [6] or major disability [3–5] of modified Rankin Scale) and European Quality of Life Scale (EQ-5D) utility scores at 90 days were assessed in logistic regression models.Results:Of 2,066 patients included in the analyses, associations were identified between ICH sites and poor outcomes: involvement of posterior limb of internal capsule increased risks of death or major disability (odds ratio [OR] 2.10) and disability (OR 1.81); thalamic involvement increased risks of death or major disability (OR 2.24) and death (OR 1.97). Involvement of the posterior limb of the internal capsule, thalamus, and infratentorial sites were each associated with poor EQ-5D utility score (≤0.7 [median]; OR 1.87, 2.14, and 2.81, respectively). Posterior limb of internal capsule involvement was strongly associated with low scores across all health-related quality of life domains. ICH encompassing the thalamus and posterior limb of internal capsule were associated with death or major disability, major disability, and poor EQ-5D utility score (OR 1.72, 2.26, and 1.71, respectively).Conclusion:Poor clinical outcomes are related to ICH affecting the posterior limb of internal capsule, thalamus, and infratentorial sites. The highest association with death or major disability and poor EQ-5D utility score was seen in ICH encompassing the thalamus and posterior limb of internal capsule.ClinicalTrials.gov registration:NCT00716079.

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Long-Term Health-Related Quality of Life in Survivors of Congenital Diaphragmatic Hernia

European Journal of Pediatric Surgery ◽

10.1055/s-0040-1713423 ◽

2020 ◽

Vol 30 (03) ◽

pp. 273-278

Author(s):

Gabrielle Derraugh ◽

Suyin A. Lum Min ◽

Richard Keijzer

Keyword(s):

Quality Of Life ◽

General Population ◽

Congenital Diaphragmatic Hernia ◽

Diaphragmatic Hernia ◽

Health Related Quality ◽

Quality Of Life Scale ◽

Related Quality ◽

Health Related ◽

Poor Outcomes

AbstractThe health-related quality of life (HRQoL) of survivors of congenital diaphragmatic hernia (CDH) is presently unknown. Literature prior to 2015 suggests that CDH survivors have worse HRQoL compared with the general population. However, due to changes in the diagnosis, management, and follow-up of CDH patients, this may no longer be true. The objective of this review was to determine what recent literature suggests regarding the HRQoL of CDH survivors. We reviewed all studies published between April 9, 2015, and April 6, 2020, that described the HRQoL of CDH survivors. Studies were identified using PubMed, and the references of the identified papers were searched for additional studies eligible for inclusion. Seven studies describing HRQoL in CDH survivors using validated measures of HRQoL for children, PedsQL (Pediatric Quality of Life Inventory), KIDSCREEN-52, and Comprehensive Quality of Life Scale – School Version were examined. The findings were disparate. One study suggested that CDH survivors had better than average HRQoL scores, three studies found patients and controls had equivalent scores, and two studies reported poor outcomes for CDH patients. The final study found no effect of disease severity on HRQoL, as determined by prenatal ultrasound. Evidence published between 2015 and 2020 suggests that CDH patients have an HRQoL equivalent to the general population.

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Clinical Outcomes and Quality of Life in Recipients of Livers Donated after Cardiac Death

Gastroenterology Research and Practice ◽

10.1155/2015/680316 ◽

2015 ◽

Vol 2015 ◽

pp. 1-7 ◽

Cited By ~ 5

Author(s):

Neehar D. Parikh ◽

Anton I. Skaro ◽

Daniela P. Ladner ◽

Vadim Lyuksemburg ◽

Joshua G. Cahan ◽

...

Keyword(s):

Quality Of Life ◽

Clinical Outcomes ◽

Cardiac Death ◽

Short Form ◽

Donation After Cardiac Death ◽

Life Questionnaire ◽

Cross Sectional ◽

Poor Outcomes ◽

Effectiveness Studies

Donation after cardiac death (DCD) has expanded in the last decade in the US; however, DCD liver utilization has flattened in recent years due to poor outcomes. We examined clinical and quality of life (QOL) outcomes of DCD recipients by conducting a retrospective and cross-sectional review of patients from 2003 to 2010. We compared clinical outcomes of DCD recipients (n=60) to those of donation after brain death (DBD) liver recipients (n=669) during the same time period. DCD recipients had significantly lower rates of 5-year graft survival (P<0.001) and a trend toward lower rates of 5-year patient survival (P=0.064) when compared to the DBD cohort. In order to examine QOL outcomes in our cohorts, we administered the Short Form Liver Disease Quality of Life questionnaire to 30 DCD and 60 DBD recipients. The DCD recipients reported lower generic and liver-specific QOL. We further stratified the DCD cohort by the presence of ischemic cholangiopathy (IC). Patients with IC reported lower QOL when compared to DBD recipients and those DCD recipients without IC (P<0.05). While the results are consistent with clinical experience, this is the first report of QOL in DCD recipients using standardized measures. These data can be used to guide future comparative effectiveness studies.

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Posterior limb of the internal capsule predicts poor quality of life in patients with Parkinson’s disease: connectometry approach

Acta Neurologica Belgica ◽

10.1007/s13760-018-0910-3 ◽

2018 ◽

Vol 119 (1) ◽

pp. 95-100 ◽

Cited By ~ 2

Author(s):

Farzaneh Ghazi Sherbaf ◽

Mahtab Mojtahed Zadeh ◽

Maryam Haghshomar ◽

Mohammad Hadi Aarabi

Keyword(s):

Quality Of Life ◽

Parkinson’S Disease ◽

Parkinson's Disease ◽

Internal Capsule ◽

Poor Quality ◽

Posterior Limb

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Demirtaş Erciyes-Mid urethral fibrin fixation technique (DE-MUFFT) for female stress urinary incontinence: A case series

Journal of Experimental and Clinical Medicine ◽

10.52142/omujecm.38.4.53 ◽

2021 ◽

Vol 38 (4) ◽

pp. 696-699

Author(s):

Türev DEMİRTAŞ ◽

Gökhan SÖNMEZ ◽

Şevket Tolga TOMBUL ◽

Abdullah DEMİRTAŞ

Keyword(s):

Quality Of Life ◽

Urinary Incontinence ◽

Stress Urinary Incontinence ◽

Clinical Outcomes ◽

Female Stress Urinary Incontinence ◽

Fixation Technique ◽

Pad Test ◽

Quality Of Life Scale ◽

Urine Leakage

Factors including suburethral blood flow impairment, collagen deficiency, and the lack of tissue healing factors are known to play a role in stress urinary incontinence (SUI). Autologous fibrin (AF) appears to be a viable material for the treatment of SUI. The aim of this study was to present the initial clinical outcomes of a novel technique named “Demirtaş Erciyes-Mid Urethral Fibrin Fixation Technique (DE-MUFFT)” that involved the placement of AF material in the suburethral space instead of sling material (mesh). In this study, the clinical outcomes of five women with pure SUI who underwent the placement of AF material in the suburethral space were examined retrospectively. The complaint of urine leakage during physical exertion and patients’ quality of life were assessed using Incontinence Quality of Life Scale (I-QoL), International Consultation on Incontinence Questionnaire-Urinary Incontinence Short Form (ICIQ-UI SF), Incontinence Impact Questionnaire (IIQ-7), and 24-h pad test. Patient outcomes were evaluated preoperatively, at sixth week and third month postoperatively. Significant improvement was obtained in the quality-of-life tests and 24-h pad test. In all patients, the complaint of urine leakage disappeared almost completely. No adverse event or postoperative complication occurred in any of the patients. These results indicated that DE-MUFFT can be a promising procedure in the treatment of SUI due to its biocompatibility, minimally invasive nature, re-applicability, and cost-effectivity.

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