Clinical Outcomes and Quality of Life in Recipients of Livers Donated after Cardiac Death

Donation after cardiac death (DCD) has expanded in the last decade in the US; however, DCD liver utilization has flattened in recent years due to poor outcomes. We examined clinical and quality of life (QOL) outcomes of DCD recipients by conducting a retrospective and cross-sectional review of patients from 2003 to 2010. We compared clinical outcomes of DCD recipients (n=60) to those of donation after brain death (DBD) liver recipients (n=669) during the same time period. DCD recipients had significantly lower rates of 5-year graft survival (P<0.001) and a trend toward lower rates of 5-year patient survival (P=0.064) when compared to the DBD cohort. In order to examine QOL outcomes in our cohorts, we administered the Short Form Liver Disease Quality of Life questionnaire to 30 DCD and 60 DBD recipients. The DCD recipients reported lower generic and liver-specific QOL. We further stratified the DCD cohort by the presence of ischemic cholangiopathy (IC). Patients with IC reported lower QOL when compared to DBD recipients and those DCD recipients without IC (P<0.05). While the results are consistent with clinical experience, this is the first report of QOL in DCD recipients using standardized measures. These data can be used to guide future comparative effectiveness studies.

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Cross-sectional study of the quality of life and functional disability report in young basketball athletes – a pilot study

ConScientiae Saúde ◽

10.5585/conssaude.v9i2.2202 ◽

2010 ◽

Vol 9 (2) ◽

pp. 206-211

Author(s):

Guilherme Manna Cesar

Keyword(s):

Quality Of Life ◽

Pilot Study ◽

Functional Disability ◽

Short Form ◽

Cross Sectional Study ◽

Life Questionnaire ◽

Medical Outcomes ◽

Young Athletes ◽

Cross Sectional

Introduction: With the increasing number of young athletes within a competitive scenario the onset of traumatic and non-traumatic injuries also increases, causing pain, dysfunction, and changes in the quality of life of these young competitors. Objective: The goal of this pilot study was to identify the domains (components) of the quality of life questionnaire of these athletes and also to evaluate whether a degree of functional disability was present. Volunteers: Twelve 16-year-old male volunteers participated in this research. Material and Method: Data collection occurred during the pre-season practices, through the application of the Brazilian Portuguese translated version of Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36), and the Oswestry Functional Disability questionnaire. This procedure was redone after 8 weeks, where the young athletes were already engaged into competition. Results: There was no statistically significant alterations (p≤0,05) considering the overall quality of life observed for the entire team, though the scores altered in most of the domains of the questionnaire. Also, the functional disability degree remained minimal throughout the competition for the sample selected.

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Home-based exercise during confinement in COVID-19 pandemic and mental health in adults: a cross-sectional comparative study

Revista Brasileira de Atividade Física & Saúde ◽

10.12820/rbafs.25e0120 ◽

2020 ◽

Vol 25 ◽

pp. 1-7

Author(s):

Luiz José Frota Solon Júnior ◽

Leonardo de Sousa Fortes ◽

Bruno Teixeira Barbosa ◽

José Valdir Alves Feitosa Júnior ◽

Carlos Henrique Tomaz Ribeiro ◽

...

Keyword(s):

Quality Of Life ◽

Sleep Quality ◽

Short Form ◽

Eating Attitudes ◽

Life Questionnaire ◽

Cross Sectional ◽

Eating Disorder Symptoms ◽

Home Based ◽

Physically Inactive

This study compared the quality of life, sleep quality, eating attitudes, and psychological aspects among adults (22.93 ± 2.58 years), whether physically inactive or not, before and during the COVID-19 pandemic. Participants were enrolled into: home-based exercise during the confinement (HBE group, n = 34), physically inactive during (PIDC group, n = 28), and before the confinement (PIBC group, n = 27). The depression, anxiety, and stress scale - Short Form, the Pittsburgh sleep quality index, the Eating Attitudes Test, and the quality of life questionnaire were used to assess variables. The covariance analysis (covariable - gender) was used to compare variables among the groups. The effect size was calculated by Cohen "d" (ESd). The HBE group presented a better quality of life compared to both PIDC (p = 0.002, ESd = 1.26) and PIBC (p = 0.008, ESd = 1.00) groups. Anxiety (p = 0.004, ESd = 0.96), depression (p = 0.02, ESd = 0.65) and stress (p = 0.02, ESd = 0.72) were significantly higher in the PIDC group when compared to HBE group. Self-reported sleep quality was better in the HBE group than in both other groups (p < 0.05). No group presented eating disorder symptoms; however, the HBE group has shown higher scores compared to both PIBC group (p = 0.01). In conclusion, adults who had exercised at home during the COVID-19 pandemic presented better quality of life, self-reported sleep quality, and reduced anxiety, depression, and stress levels than those physically inactive ones before and during the pandemic.

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Translation and Validation of the Thai Version of the Wisconsin Quality of Life Questionnaire (TH WISQoL) for Kidney Stone Patients

Journal of the Medical Association of Thailand ◽

10.35755/jmedassocthai.2020.11.11450 ◽

2020 ◽

Vol 103 (11) ◽

pp. 1194-1199

Keyword(s):

Quality Of Life ◽

Internal Consistency ◽

Kidney Stone ◽

Convergent Validity ◽

Large Scale ◽

Short Form ◽

Outcome Measurement ◽

Life Questionnaire ◽

Sf 36

Objective: To develop and validate a Thai version of the Wisconsin Quality of Life (TH WISQoL) Questionnaire. Materials and Methods: The authors developed the TH WISQoL Questionnaire based on a standard multi-step process. Subsequently, the authors recruited patients with kidney stone and requested them to complete the TH WISQoL and a validated Thai version of the 36-Item Short Form Survey (TH SF-36). The authors calculated the internal consistency and interdomain correlation of TH WISQoL and compared the convergent validity between the two instruments. Results: Thirty kidney stone patients completed the TH WISQoL and the TH SF-36. The TH WISQoL showed acceptable internal consistency for all domains (Cronbach’s alpha 0.768 to 0.909). Interdomain correlation was high for most domains (r=0.698 to 0.779), except for the correlation between Vitality and Disease domains, which showed a moderate correlation (r=0.575). For convergent validity, TH WISQoL demonstrated a good overall correlation to TH SF-36, (r=0.796, p<0.05). Conclusion: The TH WISQoL is valid and reliable for evaluating the quality of life of Thai patients with kidney stone. A further large-scale multi-center study is warranted to confirm its applicability in Thailand. Keywords: Quality of life, Kidney stone, Validation, Outcome measurement

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Development and validation of a short version of the Sarcopenia Quality of Life questionnaire: the SF-SarQoL

Quality of Life Research ◽

10.1007/s11136-021-02823-3 ◽

2021 ◽

Author(s):

A. Geerinck ◽

C. Beaudart ◽

J.-Y. Reginster ◽

M. Locquet ◽

C. Monseur ◽

...

Keyword(s):

Quality Of Life ◽

Short Form ◽

Reduction Process ◽

Community Dwelling ◽

Short Version ◽

Second Phase ◽

Life Questionnaire ◽

Quality Of Life Questionnaire ◽

Two Phases

Abstract Purpose To facilitate the measurement of quality of life in sarcopenia, we set out to reduce the number of items in the previously validated Sarcopenia Quality of Life (SarQoL®) questionnaire, and to evaluate the clinimetric properties of this new short form. Methods The item reduction process was carried out in two phases. First, information was gathered through item-impact scores from older people (n = 1950), a Delphi method with sarcopenia experts, and previously published clinimetric data. In the second phase, this information was presented to an expert panel that decided which of the items to include in the short form. The newly created SFSarQoL was then administered to older, community-dwelling participants who previously participated in the SarcoPhAge study. We examined discriminative power, internal consistency, construct validity, test–retest reliability, structural validity and examined item parameters with a graded response model (IRT). Results The questionnaire was reduced from 55 to 14 items, a 75% reduction. A total of 214 older, community-dwelling people were recruited for the validation study. The clinimetric evaluation showed that the SF-SarQoL® can discriminate on sarcopenia status [EWGSOP2 criteria; 34.52 (18.59–43.45) vs. 42.86 (26.56–63.69); p = 0.043], is internally consistent (α = 0.915, ω = 0.917) and reliable [ICC = 0.912 (0.847–0.942)]. A unidimensional model was fitted (CFI = 0.978; TLI = 0.975; RMSEA = 0.108, 90% CI 0.094–0.123; SRMR = 0.055) with no misfitting items and good response category separation. Conclusions A new, 14-item, short form version of the Sarcopenia Quality of Life questionnaire has been developed and shows good clinimetric properties.

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Quality of life of patients with lung cancer: A scoping review

Revista Brasileira de Geriatria e Gerontologia ◽

10.1590/1981-22562019022.180162 ◽

2019 ◽

Vol 22 (2) ◽

Author(s):

Rafael Turano Mota ◽

Helder Márcio Ferreira Júnior ◽

Fabiane Silva Pereira ◽

Maria Aparecida Vieira ◽

Simone de Melo Costa

Keyword(s):

Quality Of Life ◽

Lung Cancer ◽

Scoping Review ◽

Prospective Studies ◽

Current Knowledge ◽

Care Quality ◽

Life Questionnaire ◽

Cross Sectional ◽

European Organization

Abstract Objective: To characterize scientific publications on the quality of life of people with lung cancer in order to explore current knowledge of the subject, with emphasis on assessment instruments and methodological aspects. Method: A scoping type literature review was performed. Articles were sought in the databases of the Virtual Health Library, in an integrative manner, with the descriptors: Quality of life and Lung Neoplasms, with no date of publication or language restrictions (n=138). The selection of articles was based on inclusion and exclusion criteria defined in the study proposal. Results: We included 18 publications published between 2006 and 2017, the majority (n = 10) of which had a cross-sectional design. Eight different instruments were used to evaluate the quality of life of patients with lung cancer, four of which were specific for people with cancer. There was a prevalence of the use of the European Organization for Research and Treatment of Cancer Care Quality of Life Questionnaire - EORTC QLQ-C30 (n=8). Prospective studies (n=8) assessed quality of life before and after chemotherapy, physical therapy or pulmonary resection. The studies adopted different methodologies and provided conflicting results of quality of life. Cross-sectional studies with comparatively healthy subjects found an inferior quality of life for people with lung cancer. Conclusion: The scoping review contributed to the identification of the multiple evaluated instruments, both generic and specific. It found a lack of homogeneity in the methodological approaches of the studies. Further prospective studies with a specific instrument and methodological standardization to evaluate the quality of life of people with lung cancer are recommended.

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Quality of life in multiple sclerosis: The differential impact of motor and cognitive fatigue

Multiple Sclerosis Journal - Experimental Translational and Clinical ◽

10.1177/2055217321996040 ◽

2021 ◽

Vol 7 (1) ◽

pp. 205521732199604

Author(s):

Sabina David Ruban ◽

Claudia Christina Hilt ◽

Thor Petersen

Keyword(s):

Quality Of Life ◽

Multiple Sclerosis ◽

Short Form ◽

Cross Sectional Study ◽

University Hospital ◽

Cognitive Fatigue ◽

Cross Sectional ◽

Impact Scale ◽

Assessment And Treatment

Background Multiple sclerosis is a chronic disease leading to reduced quality of life. Objectives To investigate whether motor and cognitive fatigue impact differently on aspects of quality of life among patients with multiple sclerosis, independently from bodily disability. Methods 79 patients with multiple sclerosis from Aalborg University Hospital, Denmark were included in an observational, cross-sectional study. Each subject completed two separate questionnaires regarding fatigue (Fatigue Scale for Motor and Cognitive Functions and Modified Fatigue Impact Scale) and one regarding quality of life (Short Form 36). Disability was measured with the Expanded Disability Status Scale (EDSS)-scores obtained from patient records. Results All fatigue scores were significantly correlated to all areas of quality of life (p < 0,05). This remained significant after adjustment for age, disease duration and EDSS-score. When looking at each type of fatigue separately, cognitive fatigue correlated mainly with mental health aspects of quality of life and motor fatigue with physical health areas of quality of life. Conclusion Increased motor and cognitive fatigue lead to a differential reduction in physical and mental quality of life, independently of bodily disability. This underlines the importance of proper assessment and treatment of fatigue among patients with multiple sclerosis.

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Observational non-randomised controlled evaluation of the effectiveness of cancer counselling centres: a study protocol

BMJ Open ◽

10.1136/bmjopen-2019-032889 ◽

2019 ◽

Vol 9 (12) ◽

pp. e032889

Author(s):

Solveigh Paola Lingens ◽

Georgia Schilling ◽

Julia Harms ◽

Holger Schulz ◽

Christiane Bleich

Keyword(s):

Quality Of Life ◽

Short Form ◽

Control Group ◽

Life Questionnaire ◽

Psychosocial Variables ◽

European Organization ◽

Psychological Burden ◽

Patients With Cancer ◽

Small Effect Size

IntroductionIn recent years, medical treatment for cancer has improved, thereby increasing the life expectancy of patients with cancer. Hence, the focus in healthcare shifted towards analysing treatments that offer to decrease distress and improve the quality of life of patients with cancer. The psychological burden of patients with cancer originates from all kinds of psychosocial challenges related to diagnosis and treatment. Cancer counselling centres (CCounCs) try to address these concerns. However, the current literature lacks research on the effectiveness of CCounCs. This study aims to assess the effectiveness of CCounCs with regard to distress and other relevant psychosocial variables (quality of life, anxietyand so on).Methods and analysisThis prospective observational study with a non-randomised control group has three measurement points: before the first counselling session (baseline, t0) and at 2 weeks and 3 months after baseline (t1, t2). Patients and their relatives who seek counselling between December 2018 and November 2020 and have sufficient German language skills will be included. The control group will be recruited at clinics and oncological outpatient centres in Hamburg. Propensity scoring will be applied to adjust for differences between the control and intervention groups at baseline. Sociodemographic data, medical data and counselling concerns are measured at baseline. Distress (distress thermometer), quality of life (Short Form-8 Health Survey, European Organization for Research and Treatment of Cancer Core Quality of Life Questionnaire-Core 30), anxiety (Generalized AnxietyDisorder-7), depression (Patient HealthQuestionnaire-9) and further psychosocial variables are assessed at all time points. With a total of 787 participants, differences between the intervention and control groups of a small effect size (f=0.10) can be detected with a power of 80%.Ethics and disseminationThe study was registered prior to data collection with the German Registration of Clinical Trials in September 2018. Ethical approval was received by the local psychological ethical committee of the Center for Psychosocial Medicine at the University Medical Centre Hamburg-Eppendorf in August 2018. The results will be published in peer-reviewed journals.Trial registration numberDRKS00015516; Pre-results.

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Analysis of quality of life among asthmatic individuals with obesity and its relationship with pulmonary function: cross-sectional study

Sao Paulo Medical Journal ◽

10.1590/1516-3180.2016.0342250217 ◽

2017 ◽

Vol 135 (4) ◽

pp. 332-338 ◽

Cited By ~ 4

Author(s):

Letícia Baltieri ◽

Luiz Claudio Martins ◽

Everton Cazzo ◽

Débora Aparecida Oliveira Modena ◽

Renata Cristina Gobato ◽

...

Keyword(s):

Quality Of Life ◽

Pulmonary Function ◽

Cross Sectional Study ◽

University Hospital ◽

Morbidly Obese ◽

Life Questionnaire ◽

Sectional Study ◽

Anthropometric Data ◽

Cross Sectional

ABSTRACT CONTEXT AND OBJECTIVE: The combined effect of obesity and asthma may lead to significant impairment of quality of life (QOL). The aim here was to evaluate the prevalence of asthma among obese individuals, characterize the severity of impairment of quality of life and measure its relationship with pulmonary function. DESIGN AND SETTING: Observational cross-sectional study in public university hospital. METHODS: Morbidly obese individuals (body mass index > 40 kg/m2) seen in a bariatric surgery outpatient clinic and diagnosed with asthma, were included. Anthropometric data were collected, the Standardized Asthma Quality of Life Questionnaire (AQLQ(S)) was applied and spirometry was performed. The subjects were divided into two groups based on the median of the score in the questionnaire (worse < 4 and better > 4) and were compared regarding anthropometric data and pulmonary function. RESULTS: Among the 4791 individuals evaluated, 219 were asthmatic; the prevalence of asthma was 4.57%. Of these, 91 individuals were called to start multidisciplinary follow-up during the study period, of whom 82 answered the questionnaire. The median score in the AQLQ(S) was 3.96 points and, thus, the individuals were classified as having moderate impairment of their overall QOL. When divided according to better or worse QOL, there was a statistically difference in forced expiratory flow (FEF) 25-75%, with higher values in the better QOL group. CONCLUSION: The prevalence of asthma was 4.57% and QOL was impaired among the asthmatic obese individuals. The worst QOL domain related to environmental stimuli and the best QOL domain to limitations of the activities. Worse QOL was correlated with poorer values for FEF 25-75%.

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Predictors of quality of life among patients on dialysis in southern Brazil

Sao Paulo Medical Journal ◽

10.1590/s1516-31802008000500002 ◽

2008 ◽

Vol 126 (5) ◽

pp. 252-256 ◽

Cited By ~ 25

Author(s):

Maristela Bohlke ◽

Diego Leite Nunes ◽

Stela Scaglioni Marini ◽

Cleison Kitamura ◽

Marcia Andrade ◽

...

Keyword(s):

Quality Of Life ◽

Peritoneal Dialysis ◽

Short Form ◽

Outcome Measurement ◽

Cross Sectional Study ◽

Southern Brazil ◽

Cross Sectional ◽

Sf 36 ◽

Dialysis Facilities

CONTEXT AND OBJECTIVE: Quality of life (QoL) is considered important as an outcome measurement, especially for long-term diseases such as chronic renal failure. The present study searched for predictors of QoL in a sample of patients undergoing dialysis in southern Brazil. DESIGN AND SETTING: This was a cross-sectional study developed in three southern Brazilian dialysis facilities. METHODS: Health-related QoL of patients on hemodialysis or peritoneal dialysis was measured using the generic Short Form-36 (SF-36) health survey questionnaire. The results were correlated with sociodemographic, clinical and laboratory variables. The analysis was adjusted through multiple linear regression. RESULTS: A total of 140 patients were assessed: 94 on hemodialysis and 46 on peritoneal dialysis. The mean age was 54.2 ± 15.4 years, 48% were men and 76% were white. The predictors of higher (better) physical component summary in SF-36 were: younger age (β-0.16; 95% confidence interval, CI: -0.27 to -0.05), shorter time on dialysis (β-0.06; 95% CI: -0.09 to -0.02) and lower Khan comorbidity-age index (β 5.16; 95% CI: 1.7-8.6). The predictors of higher mental component summary were: being employed (β 8.4; 95% CI: 1.7-15.1), being married or having a marriage-like relationship (β 4.56; 95% CI: 0.9-8.2), being on peritoneal dialysis (β 4.9; 95% CI: 0.9-8.8) and not having high blood pressure (β 3.9; 95% CI: 0.3-7.6). CONCLUSIONS: Age, comorbidity and length of time on dialysis were the main predictors of physical QoL, whereas socioeconomic issues especially determined mental QoL.

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Quality of life in patients with Charcot-Marie-Tooth disease type 1A

Arquivos de Neuro-Psiquiatria ◽

10.1590/0004-282x20130045 ◽

2013 ◽

Vol 71 (6) ◽

pp. 392-396 ◽

Cited By ~ 2

Author(s):

Juliana B. Taniguchi ◽

Valeria M.C. Elui ◽

Flavia L. Osorio ◽

Jaime E.C. Hallak ◽

Jose A.S. Crippa ◽

...

Keyword(s):

Quality Of Life ◽

Short Form ◽

Control Group ◽

Life Questionnaire ◽

Charcot Marie Tooth ◽

Social And Emotional ◽

Charcot Marie Tooth Disease ◽

Sf 36 ◽

And Gender

We assessed the functional impairment in Charcot-Marie-Tooth resulting from 17p11.2-p12 duplication (CMT1A) patients using the Short-Form Health Survey (SF-36), which is a quality of life questionnaire. Twenty-five patients of both genders aged ≥10 years with a positive molecular diagnosis of CMT1A were selected. Age- and gender-matched Control Group (without family history of neuropathy), and the sociodemographic and professional conditions similar to the patients' group were selected to compare the SF-36 results between them. The results showed that the majority quality of life impairments in CMT1A patients occurred in the social and emotional domains. Functional capacity also tended to be significantly affected; other indicators of physical impairment were preserved. In conclusion, social and emotional aspects are mostly neglected in the assistance provided to CMT1A Brazilian patients, and they should be better understood in order to offer global health assistance with adequate quality of life as a result.

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