Reader response: Expression of Concern: Does compensatory hyperparathyroidism predispose to ischemic stroke? Decreased bone mass and increased bone turnover with valproate therapy in adults with epilepsy; An alternative to vitamin D supplementation to prevent fractures in patients with MS; High prevalence of vitamin D deficiency and reduced bone mass in Parkinson's disease

Neurology ◽  
2018 ◽  
Vol 90 (13) ◽  
pp. 627.2-628
Author(s):  
Mark J. Bolland ◽  
Alison Avenell ◽  
Greg Gamble ◽  
Andrew Grey
Keyword(s):  
Parkinson’S Disease ◽  
Vitamin D ◽  
Ischemic Stroke ◽  
Bone Mass ◽  
Bone Turnover ◽  
Vitamin D Deficiency ◽  
Reader Response ◽  
Vitamin D Supplementation ◽  
High Prevalence ◽  
Response Expression

scholarly journals The Effect of High-Dose Postpartum Maternal Vitamin D Supplementation Alone Compared with Maternal Plus Infant Vitamin D Supplementation in Breastfeeding Infants in a High-Risk Population. A Randomized Controlled Trial

Nutrients ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 1632 ◽  
Author(s):  
Adekunle Dawodu ◽  
Khalil M. Salameh ◽  
Najah S. Al-Janahi ◽  
Abdulbari Bener ◽  
Naser Elkum
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Calcium ◽  
Vitamin D3 ◽  
Controlled Trial ◽  
Vitamin D Supplementation ◽  
Urine Calcium ◽  
Randomized Controlled ◽  
High Prevalence ◽  
Maternal Supplementation

In view of continuing reports of high prevalence of severe vitamin D deficiency and low rate of infant vitamin D supplementation, an alternative strategy for prevention of vitamin D deficiency in infants warrants further study. The aim of this randomized controlled trial among 95 exclusively breastfeeding mother–infant pairs with high prevalence of vitamin D deficiency was to compare the effect of six-month post-partum vitamin D3 maternal supplementation of 6000 IU/day alone with maternal supplementation of 600 IU/day plus infant supplementation of 400 IU/day on the vitamin D status of breastfeeding infants in Doha, Qatar. Serum calcium, parathyroid hormone, maternal urine calcium/creatinine ratio and breast milk vitamin D content were measured. At baseline, the mean serum 25-hydroxyvitamin D (25(OH)D) of mothers on 6000 IU and 600 IU (35.1 vs. 35.7 nmol/L) and in their infants (31.9 vs. 29.6) respectively were low but similar. At the end of the six month supplementation, mothers on 6000 IU achieved higher serum 25(OH)D mean ± SD of 98 ± 35 nmol/L than 52 ± 20 nmol/L in mothers on 600 IU (p < 0.0001). Of mothers on 6000 IU, 96% achieved adequate serum 25(OH)D (≥50 nmol/L) compared with 52%in mothers on 600 IU (p < 0.0001). Infants of mothers on 600 IU and also supplemented with 400 IU vitamin D3 had slightly higher serum 25(OH)D than infants of mothers on 6000 IU alone (109 vs. 92 nmol/L, p = 0.03); however, similar percentage of infants in both groups achieved adequate serum 25(OH)D ≥50 nmol/L (91% vs. 89%, p = 0.75). Mothers on 6000 IU vitamin D3/day also had higher human milk vitamin D content. Safety measurements, including serum calcium and urine calcium/creatinine ratios in the mother and serum calcium levels in the infants were similar in both groups. Maternal 6000 IU/day vitamin D3 supplementation alone safely optimizes maternal vitamin D status, improves milk vitamin D to maintain adequate infant serum 25(OH)D. It thus provides an alternative option to prevent the burden of vitamin D deficiency in exclusively breastfeeding infants in high-risk populations and warrants further study of the effective dose.

High prevalence of vitamin D deficiency and reduced bone mass in multiple sclerosis

Neurology ◽  
1994 ◽  
Vol 44 (9) ◽  
pp. 1687-1687 ◽  
Author(s):  
J. Nieves ◽  
F. Cosman ◽  
J. Herbert ◽  
V. Shen ◽  
R. Lindsay
Keyword(s):  
Multiple Sclerosis ◽  
Vitamin D ◽  
Bone Mass ◽  
Vitamin D Deficiency ◽  
High Prevalence

scholarly journals Vitamin D Deficiency in HIV Infection: Not Only a Bone Disorder

2015 ◽  
Vol 2015 ◽  
pp. 1-18 ◽  
Author(s):  
Pasquale Mansueto ◽  
Aurelio Seidita ◽  
Giustina Vitale ◽  
Sebastiano Gangemi ◽  
Chiara Iaria ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Hiv Infection ◽  
Vitamin D Deficiency ◽  
Hypovitaminosis D ◽  
Vitamin D Supplementation ◽  
High Prevalence ◽  
Potential Benefits

Hypovitaminosis D is a worldwide disorder, with a high prevalence in the general population of both Western and developing countries. In HIV patients, several studies have linked vitamin D status with bone disease, neurocognitive impairment, depression, cardiovascular disease, high blood pressure, metabolic syndrome, type 2 diabetes mellitus, infections, autoimmune diseases like type 1 diabetes mellitus, and cancer. In this review, we focus on the most recent epidemiological and experimental data dealing with the relationship between vitamin D deficiency and HIV infection. We analysed the extent of the problem, pathogenic mechanisms, clinical implications, and potential benefits of vitamin D supplementation in HIV-infected subjects.

scholarly journals Effects of vitamin D supplementation on bone turnover markers and other bone-related substances in subjects with vitamin D deficiency

Bone ◽  
2019 ◽  
Vol 124 ◽  
pp. 7-13 ◽  
Author(s):  
Rolf Jorde ◽  
Astrid Kamilla Stunes ◽  
Julia Kubiak ◽  
Ragnar Joakimsen ◽  
Guri Grimnes ◽  
...  
Keyword(s):  
Vitamin D ◽  
Bone Turnover ◽  
Vitamin D Deficiency ◽  
Bone Turnover Markers ◽  
Vitamin D Supplementation ◽  
Related Substances ◽  
Turnover Markers

scholarly journals Sarcopenia and Vitamin D Deficiency in Patients with Crohn’s Disease: Pathological Conditions That Should Be Linked Together

Nutrients ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 1378
Author(s):  
Francesco Palmese ◽  
Rossella Del Toro ◽  
Giulia Di Marzio ◽  
Pierluigi Cataleta ◽  
Maria Giulia Sama ◽  
...  
Keyword(s):  
Vitamin D ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Vitamin D Deficiency ◽  
Vitamin D Supplementation ◽  
Nutrient Deficiencies ◽  
Pathological Conditions ◽  
High Prevalence ◽  
The Relationship

Sarcopenia is a prevalent condition in patients with Crohn’s disease (CD), representing an independent predictor factor for the development of major postoperative complications. Thus, a proper assessment of the muscle strength, by using different validated tools, should be deemed an important step of the clinical management of these patients. Patients with CD are frequently malnourished, presenting a high prevalence of different macro- and micro-nutrient deficiencies, including that of vitamin D. The available published studies indicate that vitamin D is involved in the regulation of proliferation, differentiation, and regeneration of muscle cells. The relationship between vitamin D deficiency and sarcopenia has been extensively studied in other populations, with interesting evidence in regards to a potential role of vitamin D supplementation as a means to prevent and treat sarcopenia. The aim of this review was to find studies that linked together these pathological conditions.

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