Better diet quality relates to larger brain tissue volumes

Neurology ◽  
2018 ◽  
Vol 90 (24) ◽  
pp. e2166-e2173 ◽  
Author(s):  
Pauline H. Croll ◽  
Trudy Voortman ◽  
M. Arfan Ikram ◽  
Oscar H. Franco ◽  
Josje D. Schoufour ◽  
...  
Keyword(s):  
White Matter ◽  
Brain Tissue ◽  
Diet Quality ◽  
White Matter Lesion ◽  
Brain Mri ◽  
Quality Score ◽  
Dietary Guidelines ◽  
Vascular Lesions ◽  
Lesion Volume ◽  
Matter Volume

ObjectiveTo investigate the relation of diet quality with structural brain tissue volumes and focal vascular lesions in a dementia-free population.MethodsFrom the population-based Rotterdam Study, 4,447 participants underwent dietary assessment and brain MRI scanning between 2005 and 2015. We excluded participants with an implausible energy intake, prevalent dementia, or cortical infarcts, leaving 4,213 participants for the current analysis. A diet quality score (0–14) was calculated reflecting adherence to Dutch dietary guidelines. Brain MRI was performed to obtain information on brain tissue volumes, white matter lesion volume, lacunes, and cerebral microbleeds. The associations of diet quality score and separate food groups with brain structures were assessed using multivariable linear and logistic regression.ResultsWe found that better diet quality related to larger brain volume, gray matter volume, white matter volume, and hippocampal volume. Diet quality was not associated with white matter lesion volume, lacunes, or microbleeds. High intake of vegetables, fruit, whole grains, nuts, dairy, and fish and low intake of sugar-containing beverages were associated with larger brain volumes.ConclusionsA better diet quality is associated with larger brain tissue volumes. These results suggest that the effect of nutrition on neurodegeneration may act via brain structure. More research, in particular longitudinal research, is needed to unravel direct vs indirect effects between diet quality and brain health.

scholarly journals APOL1 renal-risk variants associate with reduced cerebral white matter lesion volume and increased gray matter volume

2016 ◽  
Vol 90 (2) ◽  
pp. 440-449 ◽  
Author(s):  
Barry I. Freedman ◽  
Crystal A. Gadegbeku ◽  
R. Nick Bryan ◽  
Nicholette D. Palmer ◽  
Pamela J. Hicks ◽  
...  
Keyword(s):  
White Matter ◽  
Gray Matter ◽  
White Matter Lesion ◽  
Gray Matter Volume ◽  
Cerebral White Matter ◽  
Lesion Volume ◽  
Matter Volume ◽  
Risk Variants ◽  
Cerebral White Matter Lesion

Abstract T P234: Multiparametric Assessment of Longitudinal Changes in Tissue Microstructure in Normal and Abnormal Brain Tissue in Patients with Small Vessel Disease

Stroke ◽  
2015 ◽  
Vol 46 (suppl_1) ◽  
Author(s):  
Maria D Valdes-Hernandez ◽  
Paul A Armitage ◽  
Eleni Sakka ◽  
Susana Munoz Maniega ◽  
Natalie A Royle ◽  
...  
Keyword(s):  
White Matter ◽  
Brain Tissue ◽  
Small Vessel Disease ◽  
Brain Mri ◽  
Mean Diffusivity ◽  
Tissue Loss ◽  
Minor Stroke ◽  
Normal Brain ◽  
Limited Information ◽  
Time Points

Background: Volume measures of normal brain tissue and white matter hyperintensities (WMH) between two time points gives limited information about the complex dynamics of tissue change. We evaluated two quantitative parameters that characterise the microstructure of normal-appearing white matter (NAWM), deep grey matter (DGM) and WMH on brain images obtained at presentation with minor stroke and at 1 year to investigate the microstructural changes. Methods: From 182 brain MRI datasets of patients with minor stroke obtained at baseline and 1 year, we extracted the WMH, DGM and NAWM, and separated WMH into less-intense and intense WMH, using validated semi-automatic methods and validated criteria. We registered the binary structural masks to diffusion space and performed a voxel-wise subtraction of the combined masks at both time points. Then we measured fractional anisotropy (FA) and mean diffusivity (MD)(valuex10 -9 m 2 /s) in each tissue mask at baseline and 1 year. Results: WMH volume median increase was 1.4ml (IQR 6.98) mainly due to changes in less-intense WMH: 0.94ml (7.13). WMH that were visible at both time points, ie damage that remained after a year, had the lowest FA= 0.21(0.06) and highest MD=1.05(0.12) at baseline, and were mainly intense WMH at baseline (FA=0.12(0.03), MD=1.55(0.27)). WMH seen only at follow-up, ie that were NAWM at baseline, had the highest FA=0.30(0.06) and lowest MD=0.85 (0.06) at baseline. WMH that were observed only at baseline had intermediate FA=0.26(0.08) and MD=0.90(0.10). NAWM FA=0.26(0.03), MD=0.78(0.04) and DGM FA=0.23(0.03), MD=0.79(0.06) did not change between time points. Conclusions: WMH at baseline can partially evolve to normal-appearing tissues, remain or precede tissue loss. Differentiation between severe and subtle damage and spatial analysis are necessary to characterise the dynamic of WMH evolution.

Antidepressant use is related to larger white matter lesion volume in patients with symptomatic atherosclerotic disease: the SMART-MR study

2012 ◽  
Vol 260 (1) ◽  
pp. 197-206 ◽  
Author(s):  
Anne M. Grool ◽  
Yolanda Graaf ◽  
Koen L. Vincken ◽  
Theo D. Witkamp ◽  
Willem P. Th. M. Mali ◽  
...  
Keyword(s):  
White Matter ◽  
White Matter Lesion ◽  
Atherosclerotic Disease ◽  
Lesion Volume ◽  
Antidepressant Use ◽  
Mr Study

scholarly journals Replication Study of Chr17q25 With Cerebral White Matter Lesion Volume

Stroke ◽  
2011 ◽  
Vol 42 (11) ◽  
pp. 3297-3299 ◽  
Author(s):  
Benjamin F.J. Verhaaren ◽  
Renske de Boer ◽  
Meike W. Vernooij ◽  
Fernando Rivadeneira ◽  
André G. Uitterlinden ◽  
...  
Keyword(s):  
White Matter ◽  
White Matter Lesion ◽  
Replication Study ◽  
Cerebral White Matter ◽  
Lesion Volume ◽  
Cerebral White Matter Lesion

scholarly journals Progression of White Matter Lesion Volume and Health-Related Quality of Life in Patients with Symptomatic Atherosclerotic Disease: The SMART-MR Study

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Anne M. Grool ◽  
Yolanda van der Graaf ◽  
Theo D. Witkamp ◽  
Koen L. Vincken ◽  
Willem P. T. M. Mali ◽  
...  
Keyword(s):  
White Matter ◽  
Physical Functioning ◽  
White Matter Lesion ◽  
Short Form ◽  
Arterial Disease ◽  
Atherosclerotic Disease ◽  
Lesion Volume ◽  
Mental Functioning ◽  
Related Quality ◽  
Mr Study

Objectives. Mechanisms influencing the course of physical and mental functioning after an atherosclerotic event are unclear. We examined effects of white matter lesion (WML) activity on changes in functioning in patients with symptomatic atherosclerotic disease.Methods. In 486 patients (58±9years) of the Second Manifestations of ARTerial disease-Magnetic Resonance (SMART-MR) study, volumetric WML measurements on 1.5T MRI were performed at baseline and3.9±0.4years followup. Functioning was assessed with the modified Short-Form 12 (SF-12) questionnaire. Associations of WML progression with changes in functioning were adjusted for age, sex, and vascular risk factors.Results. Physical functioning (baseline: 44, 10th–90th percentile 29–55) improved, whereas mental functioning (baseline: 51, 10th–90th percentile 32–60) declined during followup. WML progression (highest quartile versus rest) contributed to a stronger decline in mental functioning (B=−1.76, 95% CI −3.11 to −0.42), but did not influence changes in physical functioning.Conclusions. Progression of WML volume contributes to a decline in mental functioning in patients with symptomatic atherosclerotic disease.

scholarly journals Long-term cerebral white and gray matter changes after preeclampsia

Neurology ◽  
2017 ◽  
Vol 88 (13) ◽  
pp. 1256-1264 ◽  
Author(s):  
Timo Siepmann ◽  
Henry Boardman ◽  
Amy Bilderbeck ◽  
Ludovica Griffanti ◽  
Yvonne Kenworthy ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
White Matter ◽  
Temporal Lobe ◽  
Gray Matter ◽  
Diffusion Tensor ◽  
Brain Mri ◽  
Risk Profile ◽  
Lesion Volume ◽  
Cardiovascular Risk Profile ◽  
Microstructural Integrity

Objective:To determine whether changes in cerebral structure are present after preeclampsia that may explain increased cerebrovascular risk in these women.Methods:We conducted a case control study in women between 5 and 15 years after either a preeclamptic or normotensive pregnancy. Brain MRI was performed. Analysis of white matter structure was undertaken using voxel-based segmentation of fluid-attenuation inversion recovery sequences to assess white matter lesion volume and diffusion tensor imaging to measure microstructural integrity. Voxel-based analysis of gray matter volumes was performed with adjustment for skull size.Results:Thirty-four previously preeclamptic women (aged 42.8 ± 5.1 years) and 49 controls were included. Previously preeclamptic women had reduced cortical gray matter volume (523.2 ± 30.1 vs 544.4 ± 44.7 mL, p < 0.05) and, although both groups displayed white matter lesions, changes were more extensive in previously preeclamptic women. They displayed increased temporal lobe white matter disease (lesion volume: 23.2 ± 24.9 vs 10.9 ± 15.0 μL, p < 0.05) and altered microstructural integrity (radial diffusivity: 538 ± 19 vs 526 ± 18 × 10−6 mm2/s, p < 0.01), which also extended to occipital and parietal lobes. The degree of temporal lobe white matter change in previously preeclamptic women was independent of their current cardiovascular risk profile (p < 0.05) and increased with time from index pregnancy (p < 0.05).Conclusion:A history of preeclampsia is associated with temporal lobe white matter changes and reduced cortical volume in young women, which is out of proportion to their classic cardiovascular risk profile. The severity of changes is proportional to time since pregnancy, which would be consistent with continued accumulation of damage after pregnancy.

scholarly journals Carotid Arterial Stiffness Predicts White Matter Lesion Volume in Older Adults

2018 ◽  
Vol 32 (S1) ◽  
Author(s):  
Christopher S. Balestrini ◽  
Baraa K. Al‐Khazraji ◽  
Navena R. Lingum ◽  
Jennifer L. Vording ◽  
Neville Suskin ◽  
...  
Keyword(s):  
Older Adults ◽  
White Matter ◽  
Arterial Stiffness ◽  
White Matter Lesion ◽  
Lesion Volume ◽  
Carotid Arterial
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