Association of Refractory Pain in the Acute Phase After Subarachnoid Hemorrhage with Continued Outpatient Opioid Use

Neurology ◽  
2021 ◽  
pp. 10.1212/WNL.0000000000011906
Author(s):  
Matthew N. Jaffa ◽  
Jamie E. Podell ◽  
Madeleine C. Smith ◽  
Arshom Foroutan ◽  
Adam Kardon ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Ethnic Minority ◽  
Acute Phase ◽  
Acute Illness ◽  
Minority Status ◽  
Opioid Use ◽  
Opioid Dose ◽  
Refractory Pain ◽  
Racial Ethnic

ObjectiveLittle is known about the prevalence of continued opioid use following aneurysmal subarachnoid hemorrhage (aSAH) despite guidelines recommending their use during the acute phase of disease. We sought to determine prevalence of opioid use following aSAH and test the hypothesis that acute pain and higher inpatient opioid dose increased outpatient opioid use.MethodsWe reviewed consecutively admitted aSAH patients from November 2015 through September 2019. We retrospectively collected pain scores and daily doses of analgesics. Pain burden was calculated as area under the pain-time curve. Univariate and multivariable regression models determined risk factors for continued opioid use at discharge and outpatient follow-up.ResultsWe identified 234 aSAH patients with outpatient follow-up. Continued opioid use was common at discharge (55% of patients) and follow-up (47% of patients, median 63 (IQR 49–96) days from admission). Pain burden, craniotomy, and racial-ethnic minority status were associated with discharge opioid prescription in multivariable analysis. At outpatient follow-up, pain burden (OR 1.88, 95% CI 1.5–2.4), depression (OR 3.1, 95% CI 1.1–8.8), and racial-ethnic minority status (OR 2.1, 95% CI 1.1–4.0) were independently associated with continued opioid use while inpatient opioid dose was not.ConclusionContinued opioid use following aSAH is prevalent and related to refractory pain during acute illness, but not inpatient opioid dose. More efficacious analgesic strategies are needed to reduce continued opioid use in patients following aSAH.Classification of evidenceThis study provides Class II evidence that continued opioid use following aSAH is associated with refractory pain during acute illness but not hospital opioid exposure.

Abstract 22: Affordable Care Act Medicaid Expansion Then and Now: Racial/Ethnic Differences in Receipt of Guideline-Directed Medical Therapy During Heart Failure Hospitalizations

2020 ◽  
Vol 13 (Suppl_1) ◽  
Author(s):  
Khadijah K Breathett ◽  
Haolin Xu ◽  
Nancy K Sweitzer ◽  
Elizabeth Calhoun ◽  
Roland Matsouaka ◽  
...  
Keyword(s):  
Heart Failure ◽  
Ethnic Minority ◽  
Ethnic Groups ◽  
Affordable Care Act ◽  
Medicaid Expansion ◽  
Early Adopter ◽  
Angiotensin Receptor ◽  
To Receive ◽  
Racial Ethnic

Introduction: Uninsurance is a known contributor to racial/ethnic minority health inequities. Insurance is needed for prescription medications and follow-up visits with specialists. Among racial/ethnic minority patients hospitalized with heart failure (HF), it is not well studied whether the Affordable Care Act (ACA) Medicaid Expansion was associated with increased receipt of guideline-directed medical treatment (GDMT) on discharge from HF hospitalization. Methods: Using Get With The Guidelines-HF registry, logistic regression models were used to assess the odds of receiving GDMT [angiotensin converting enzyme inhibitor(ACE)/ angiotensin receptor blocker (ARB)/ angiotensin receptor-neprilysin inhibitor(ARNI); beta blocker; aldosterone antagonist; hydralazine/nitrate; HF education; HF follow-up appointment] in early adopter versus non-adopter states in the periods before (2012-2013) and after ACA Medicaid Expansion (2014-2019) within each race/ethnicity. Models were adjusted for patient-level covariates and generalized estimating equations addressed within-hospital clustering. The interaction (p-int) between adopter state status and timing of ACA Medicaid Expansion (2014) was evaluated. Results: Among 271,606 patients (57.5% early adopter, 42.5% non-adopter states), 65.5% were White, 22.8% were African-American, 8.9% were Hispanic, and 2.9% were Asian. In fully adjusted analyses, ACA Medicaid Expansion was associated with significant likelihood of receipt of ACE/ARB/ARNI at discharge in Hispanics [before ACA: OR 0.40 (95% CI: 0.13, 1.23); after ACA: OR 2.46 (95% CI 1.10, 5.51); p-int <0.01]. Asians were more likely to receive a HF follow-up appointment [before ACA: OR 0.64 (0.20, 2.06); after ACA: OR 1.44 (0.50, 4.15); p-int 0.03]. No significant differences were found in receipt of GDMT at the time of ACA Medicaid Expansion for other racial/ethnic groups. Independent of timing of ACA, Hispanics were more likely to receive all GDMT if they resided in an early adopter state compared to non-adopter state (p<0.01). Individual evidence-based treatments varied by state group independent of ACA timing for other racial/ethnic groups. With the exception of ACE/ARB/ARNI, beta blockers, and HF follow-up, <60% of patients in both state groups received other forms of GDMT despite eligibility. Conclusions: Among patients hospitalized with HF at centers voluntarily participating in a national quality improvement program, the ACA Medicaid Expansion was associated with increased receipt of ACE/ARB/ARNI in Hispanics, and increased receipt of follow-up appointments in Asians. Independent of the ACA, Hispanics residing in early adopter states were more likely to receive GDMT than Hispanics in non-adopter states. Futher expansion of ACA may reduce racial/ethnic disparities in HF; however, additional steps must be taken to overcome barriers to prescribing GDMT to all.

scholarly journals Quality of Follow-Up After Hospitalization for Mental Illness Among Patients From Racial-Ethnic Minority Groups

2014 ◽  
Vol 65 (7) ◽  
pp. 888-896 ◽  
Author(s):  
Nicholas J. Carson ◽  
Andrew Vesper ◽  
Chih-nan Chen ◽  
Benjamin Lê Cook
Keyword(s):  
Mental Illness ◽  
Ethnic Minority ◽  
Minority Groups ◽  
Ethnic Minority Groups ◽  
Racial Ethnic

scholarly journals Social Support and Attachment to Pets Moderate the Association between Sexual and Gender Minority Status and the Likelihood of Delaying or Avoiding COVID-19 Testing

2021 ◽  
Vol 10 (8) ◽  
pp. 301
Author(s):  
Angela Matijczak ◽  
Jennifer W. Applebaum ◽  
Shanna K. Kattari ◽  
Shelby E. McDonald
Keyword(s):  
Social Support ◽  
Ethnic Minority ◽  
Moderating Effect ◽  
Minority Status ◽  
Gender Minority ◽  
Treatment Services ◽  
Sexual And Gender Minority ◽  
Additional Barrier ◽  
And Gender ◽  
Racial Ethnic

Sexual and gender minority individuals (SGM) face barriers to accessing COVID-19 testing and treatment services. Living with pets may pose an additional barrier due to concerns about pet welfare. This study investigates whether the relation between SGM status and the likelihood of delaying or avoiding testing and treatment for COVID-19 varies as a function of attachment to pets and social support. Our sample consisted of 1453 adults (Mage = 39.4 years, 12.6% racial/ethnic minority; 21.8% SGM). We conducted simple and additive multiple moderation analyses to investigate the moderating effect of attachment to pets and social support on the relation between SGM status and the likelihood of delaying or avoiding COVID-19 testing or treatment. Attachment to pets moderated the association between SGM status and the likelihood of delaying or avoiding COVID-19 testing in the simple (β = 0.82, Z = 2.09, p = 0.04) and additive multiple moderation analyses (β = 0.82, Z = 2.05, p = 0.04). SGM participants were more likely than non-SGM participants to report that they would delay or avoid testing when they reported high attachment to their pet (β = 0.75, OR = 2.11, Z = 2.51, p = 0.01) and low (β = 0.75, OR = 2.12, Z = 2.48, p = 0.01) or moderate (β = 0.73, OR = 2.08, Z = 2.14, p = 0.03) levels of social support.

Changes in M.P.I. Scores in Neurotic Patients: A Three Year Follow-up

1966 ◽  
Vol 112 (490) ◽  
pp. 931-939 ◽  
Author(s):  
J. G. Ingham
Keyword(s):  
Acute Phase ◽  
Psychiatric Diagnosis ◽  
Practical Importance ◽  
Temporal Stability ◽  
Acute Illness ◽  
Reliable Information ◽  
Clinical State ◽  
Stable Characteristic

Do the relatively high N-scores observed in neurotic patients reflect a stable characteristic of the neurotic's personality, or are they temporary manifestations occurring only in the acute phase of the illness? Similarly, do the relatively low E-scores of dysthymic patients remain low through variations of clinical state or are they also temporary? The temporal stability of M.P.I. scores is of some practical importance. Criteria for psychiatric diagnosis often include assessments of personality before the illness. Fairly reliable information about this can often be obtained from relatives, but in other cases the clinician is faced with a problem that might appear insoluble. How is he to assess previous personality during an acute illness which may influence the behaviour on which personality is judged?

scholarly journals Treatment of ruptured complex and large/giant ruptured cerebral aneurysms by acute coiling followed by staged flow diversion

2016 ◽  
Vol 125 (1) ◽  
pp. 120-127 ◽  
Author(s):  
Waleed Brinjikji ◽  
Mariangela Piano ◽  
Shanna Fang ◽  
Guglielmo Pero ◽  
David F. Kallmes ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Acute Phase ◽  
Case Series ◽  
Flow Diverter ◽  
Flow Diversion ◽  
Endovascular Coiling ◽  
Ruptured Aneurysms ◽  
Permanent Morbidity ◽  
Intent To Treat

OBJECT Flow-diversion treatment has been shown to be associated with high rates of angiographic obliteration; however, the treatment is relatively contraindicated in the acute phase following subarachnoid hemorrhage (SAH) as these patients require periprocedural dual antiplatelet therapy. Acute coiling followed by flow diversion has emerged as an intriguing and feasible treatment option for ruptured complex and giant aneurysms. In this study the authors report outcomes and complications of patients with ruptured aneurysms undergoing coiling in the acute phase followed by planned delayed flow diversion. METHODS This case series includes patients from 2 institutions. All patients underwent standard endovascular coiling in the acute phase after SAH with the intention and plan to proceed with flow diversion at a later date. Outcomes studied included angiographic occlusion, procedure-related complications, and long-term clinical outcome as measured using the modified Rankin Scale. RESULTS A total of 31 patients underwent coiling in the acute phase with the intention to undergo flow diversion at a later date. The mean aneurysm size was 15.8 ± 7.9 mm. Of the 31 patients undergoing coiling, 4 patients could not undergo further flow-diverter therapy: 3 patients (9.7%) died of complications of subarachnoid hemorrhage and 1 patient had permanent morbidity as a result of perioperative ischemic stroke (3.1%). Twenty-seven patients underwent staged placement of flow diverters after adequate recovery. The median time to treatment was 16 weeks. There was one case of aneurysm rebleeding following coil treatment. There were no cases of permanent morbidity or mortality resulting from flow-diverter treatment. Twenty-four patients underwent imaging follow-up; 18 of these patients had aneurysms that were completely or nearly completely occluded (58.1% on an intent-to-treat basis). At last follow-up (mean 18.3 months), 25 patients had mRS scores ≤ 2 (80.6% on an intent-to-treat basis). CONCLUSIONS Staged treatment of ruptured complex and giant intracranial aneurysms with coiling in the acute phase and flow-diverter treatment following recovery from SAH is both safe and effective. In this series, no cases of rebleeding occurred during the interval between coiling and flow diversion. This strategy should be considered as a valid option in patients presenting with these challenging ruptured aneurysms.

Abstract TP456: Coated-platelets Levels After Subarachnoid Hemorrhage Predict Post-discharge Short-term Cognitive Outcome

Stroke ◽  
2016 ◽  
Vol 47 (suppl_1) ◽  
Author(s):  
Bappaditya Ray ◽  
Vijay M Pandav ◽  
Eleanor A Mathews ◽  
David M Thompson ◽  
Aminata A Traore ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Acute Phase ◽  
Delayed Cerebral Ischemia ◽  
Cognitive Outcome ◽  
Short Term ◽  
Post Discharge ◽  
Acute Hospitalization ◽  
Symptomatic Vasospasm

Introduction: Delayed cerebral ischemia (DCI) is a determinant of short-term and long-term morbidity after subarachnoid hemorrhage (SAH). DCI is likely due to neurohumoral activation and inflammation-thrombosis cross-talk during the acute phase. Coated-platelets (CP), a subset of procoagulant platelets, contribute to systemic thrombogenicity and are associated with recurrent ischemic stroke. Hypothesis: We hypothesized that high CP levels during first 3 weeks of SAH (acute hospitalization) would be associated with worse short-term clinical outcome. Methods: A prospective cohort of 28 patients with post-discharge clinical follow-up (average 12 weeks) was studied. Outcomes were assessed using modified Rankin Scale (mRS) and Montreal Cognitive Outcome Assessment (MOCA). Blood samples to measure CP levels were performed - 1) during acute hospitalization and 2) at follow-up visit (defined as patient’s baseline). Trend of CP during acute hospitalization was analyzed against weighted mean baseline CP level to test hypothesis. Results: Average age of cohort was 52.6±12.2 years with 71.5% women. During acute phase 9 (32.1%) patients developed symptomatic vasospasm and 14 (50%) had DCI on imaging. Baseline CP levels did not differ (p=0.118) between patients with MOCA ≥26 (41.3%, n=13) and MOCA <26 (29.5%, n=15). However, patients with MOCA <26 had significantly higher CP levels during first 5 days than baseline (50.4% vs 29.5%, p=0.0004). These levels decreased by 1.77%/day from 6-21 days as compared to 1.55%/day for patients with MOCA ≥26 (p=0.723). In contrast, 20 (71.4%) patients with mRS 0-2 had average baseline CP levels of 37.3% vs 8 (28.6%) with mRS 3-6 having CP levels of 31.7%. For patients with mRS 0-2 and mRS 3-6, CP levels increased from baseline during first 5 days after SAH by 10.3% and 16.5% respectively (not statistically significant). Rate of CP decrease during 6-21 days was 1.43%/day and 2.02%/day (p=0.259) for mRS 0-2 and mRS 3-6 respectively. Conclusion: Elevated CP levels during the acute phase of SAH are strongly associated with lower MOCA scores at 12 weeks but not with higher mRS assessment. These results suggest that increased thrombogenicity after SAH leads to cognitive impairment despite good physical outcomes.

scholarly journals Bedside optical coherence tomography for Terson’s syndrome screening in acute subarachnoid hemorrhage: a pilot study

2019 ◽  
Vol 130 (2) ◽  
pp. 517-524 ◽  
Author(s):  
Ciro Ramos-Estebanez ◽  
Maryo Kohen ◽  
Jonathan Pace ◽  
Alireza Bozorgi ◽  
Sunil Manjila ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Optical Coherence Tomography ◽  
Subarachnoid Hemorrhage ◽  
Pilot Study ◽  
Acute Phase ◽  
Depressed Mood ◽  
Potential Role ◽  
Optical Coherence

OBJECTIVEApproximately 10% of patients with subarachnoid hemorrhage (SAH) become permanently, legally blind. The average cost of lifetime support and unpaid taxes for each blind person amounts to approximately $900,000. This study evaluates the feasibility and potential role of bedside optical coherence tomography (OCT) in Terson’s syndrome (TS) in patients with acute SAH (aSAH) and its potential role in blindness prevention.METHODSThe authors conducted an open-label pilot study, in which 31 patients with an angiographic diagnosis of aSAH were first screened for TS with dilated funduscopy and then with OCT in the acute phase and at 6-week follow-up visits. Outpatient mood assessments (Patient Health Questionnaire–depression module, Hamilton Depression Scale), and quality of life general (NIH Patient-Reported Outcomes Measurement Information System) and visual scales (25-item National Eye Institute Visual Functioning Questionnaire) were measured at 1 and 6 weeks after discharge. Exclusion criteria included current or previous history of severe cataracts, severe diabetic retinopathy, severe macular degeneration, or glaucoma.RESULTSOCT identified 7 patients with TS, i.e., a 22.6% incidence in our aSAH sample: 7 in the acute phase, including a large retinal detachment that was initially missed by funduscopy and diagnosed by OCT in follow-up clinic. Dilated retinal funduscopy significantly failed to detect TS in 4 (57.1%) of these 7 cases. Intraventricular hemorrhage was significantly more common in TS cases (85.7% vs 25%). None of the participants experienced any complications from OCT examinations. Neither decreased quality of life visual scale scores nor a depressed mood correlated with objective OCT pathological findings at the 6-week follow-up after discharge. There were no significant mood differences between TS cases and controls.CONCLUSIONSOCT is the gold standard in retinal disease diagnosis. This pilot study shows that bedside OCT examination is feasible in aSAH. In this series, OCT was a safe procedure that enhanced TS detection by decreasing false-negative/inconclusive funduscopic examinations. It allows early diagnosis of macular holes and severe retinal detachments, which require acute surgical therapy to prevent legal blindness. In addition, OCT aids in ruling out potential false-positive visual deficits in individuals with a depressed mood at follow-up.

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