Subcellular distribution and physicochemical properties of scrapie-associated precursor protein and relationship with scrapie agent

Neurology ◽  
1990 ◽  
Vol 40 (3, Part 1) ◽  
pp. 503-503 ◽  
Author(s):  
J. Safar ◽  
M. Ceroni ◽  
P. Piccardo ◽  
P. P. Liberski ◽  
M. Miyazaki ◽  
...  
Keyword(s):  
Physicochemical Properties ◽  
Subcellular Distribution ◽  
Precursor Protein ◽  
Scrapie Agent

The scrapie agent precursor protein is a normal constituent of neurons and lymphocytes

1991 ◽  
Vol 35 ◽  
pp. 82
Author(s):  
P.E. Bendheim ◽  
D.C. Bolton ◽  
R.J. Kascsak ◽  
R. Loertscher ◽  
I. Shaw ◽  
...  
Keyword(s):  
Precursor Protein ◽  
Scrapie Agent ◽  
Normal Constituent

GGA1 overexpression alters trafficking and subcellular distribution of the amyloid precursor protein

2005 ◽  
Vol 32 (S 4) ◽  
Author(s):  
C.A.F von Arnim ◽  
I.D Peltan ◽  
M Deng ◽  
S Courchesne ◽  
S.F Lichtenthaler ◽  
...  
Keyword(s):  
Amyloid Precursor Protein ◽  
Subcellular Distribution ◽  
Precursor Protein

scholarly journals SNX27 and SORLA Interact to Reduce Amyloidogenic Subcellular Distribution and Processing of Amyloid Precursor Protein

2016 ◽  
Vol 36 (30) ◽  
pp. 7996-8011 ◽  
Author(s):  
Timothy Y. Huang ◽  
Yingjun Zhao ◽  
Xiaoguang Li ◽  
Xin Wang ◽  
I-Chu Tseng ◽  
...  
Keyword(s):  
Amyloid Precursor Protein ◽  
Subcellular Distribution ◽  
Precursor Protein

Nearly ubiquitous tissue distribution of the scrapie agent precursor protein

Neurology ◽  
1992 ◽  
Vol 42 (1) ◽  
pp. 149-149 ◽  
Author(s):  
P. E. Bendheim ◽  
H. R. Brown ◽  
R. D. Rudelli ◽  
L. J. Scala ◽  
N. L. Goller ◽  
...  
Keyword(s):  
Tissue Distribution ◽  
Precursor Protein ◽  
Scrapie Agent

scholarly journals The cholesterol transporter ABCG1 modulates the subcellular distribution and proteolytic processing of β-amyloid precursor protein

2007 ◽  
Vol 48 (5) ◽  
pp. 1022-1034 ◽  
Author(s):  
Gavin H. Tansley ◽  
Braydon L. Burgess ◽  
Matt T. Bryan ◽  
Yuan Su ◽  
Veronica Hirsch-Reinshagen ◽  
...  
Keyword(s):  
Amyloid Precursor Protein ◽  
Subcellular Distribution ◽  
Proteolytic Processing ◽  
Precursor Protein ◽  
Β Amyloid

Altered Subcellular Distribution of the Alzheimer's Amyloid Precursor Protein Under Stress Conditions

2007 ◽  
Vol 1096 (1) ◽  
pp. 184-195 ◽  
Author(s):  
S. C.T.S. DOMINGUES ◽  
A. G. HENRIQUES ◽  
W. WU ◽  
E. F. DA CRUZ E SILVA ◽  
O. A.B. DA CRUZ E SILVA
Keyword(s):  
Amyloid Precursor Protein ◽  
Subcellular Distribution ◽  
Stress Conditions ◽  
Precursor Protein

Preparation and characterisation of vanadium pentoxide supported rhodium catalyst

1988 ◽  
Vol 46 ◽  
pp. 946-947
Author(s):  
A. Legrouri
Keyword(s):  
Aqueous Solution ◽  
Thermal Decomposition ◽  
Physicochemical Properties ◽  
Surface Area ◽  
Vanadium Pentoxide ◽  
High Purity ◽  
Gas Adsorption ◽  
Rhodium Catalyst ◽  
Optical Methods ◽  
Reducible Oxides

The industrial importance of metal catalysts supported on reducible oxides has stimulated considerable interest during the last few years. This presentation reports on the study of the physicochemical properties of metallic rhodium supported on vanadium pentoxide (Rh/V2O5). Electron optical methods, in conjunction with other techniques, were used to characterise the catalyst before its use in the hydrogenolysis of butane; a reaction for which Rh metal is known to be among the most active catalysts.V2O5 powder was prepared by thermal decomposition of high purity ammonium metavanadate in air at 400 °C for 2 hours. Previous studies of the microstructure of this compound, by HREM, SEM and gas adsorption, showed it to be non— porous with a very low surface area of 6m2/g3. The metal loading of the catalyst used was lwt%Rh on V2Q5. It was prepared by wet impregnating the support with an aqueous solution of RhCI3.3H2O.

Memapsin 2, a drug target for Alzheimer's disease

2003 ◽  
Vol 70 ◽  
pp. 213-220 ◽  
Author(s):  
Gerald Koelsch ◽  
Robert T. Turner ◽  
Lin Hong ◽  
Arun K. Ghosh ◽  
Jordan Tang
Keyword(s):  
Crystal Structure ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Transition State ◽  
Amyloid Precursor Protein ◽  
Therapeutic Target ◽  
Drug Target ◽  
Aspartic Protease ◽  
Precursor Protein ◽  
Memapsin 2

Mempasin 2, a ϐ-secretase, is the membrane-anchored aspartic protease that initiates the cleavage of amyloid precursor protein leading to the production of ϐ-amyloid and the onset of Alzheimer's disease. Thus memapsin 2 is a major therapeutic target for the development of inhibitor drugs for the disease. Many biochemical tools, such as the specificity and crystal structure, have been established and have led to the design of potent and relatively small transition-state inhibitors. Although developing a clinically viable mempasin 2 inhibitor remains challenging, progress to date renders hope that memapsin 2 inhibitors may ultimately be useful for therapeutic reduction of ϐ-amyloid.

Interplay between Pur α and Egr-1 in the transcriptional regulation of amyloid precursor protein gene expression

2010 ◽  
Vol 34 (8) ◽  
pp. S27-S27
Author(s):  
Jianqi Cui ◽  
Xiuying Pei ◽  
Qian Zhang ◽  
Bassel E. Sawaya ◽  
Xiaohong Lu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Transcriptional Regulation ◽  
Amyloid Precursor Protein ◽  
Protein Gene ◽  
Precursor Protein ◽  
Amyloid Precursor Protein Gene
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