A Prospective Study of Quality of Life in Adults with Newly Diagnosed High-grade Gliomas: The Impact of the Extent of Resection on Quality of Life and Survival

Neurosurgery ◽  
2005 ◽  
Vol 57 (3) ◽  
pp. 495-504 ◽  
Author(s):  
Paul D. Brown ◽  
Matthew J. Maurer ◽  
Teresa A. Rummans ◽  
Bruce E. Pollock ◽  
Karla V. Ballman ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Extent Of Resection ◽  
High Grade ◽  
Newly Diagnosed ◽  
Total Resection ◽  
Multivariable Analyses ◽  
High Grade Gliomas ◽  
Over Time

ABSTRACT OBJECTIVE: To describe the quality of life (QOL) over time for adults with newly diagnosed high-grade gliomas and to examine the relationship between QOL and outcome data collected in three prospective cooperative group clinical trials. METHODS: The QOL study was a companion protocol for three Phase II high-grade glioma protocols. Five self-administered forms were completed by patients to assess QOL at study entry, 2 months, and 4 months after enrollment. RESULTS: QOL data were available for baseline, first, and second subsequent follow-up evaluations for 89%, 71%, and 69% of patients, respectively. A significant proportion of patients (47.1%) experienced impaired QOL (QOL ≤ 50) in at least one measure at subsequent evaluations, whereas most patients (88%) with impaired QOL at baseline continued to have impaired QOL at subsequent evaluations. On multivariable analyses, baseline QOL measures were predictive of QOL at the time of follow-up. In addition, patients who underwent a gross total resection were much less likely to have impaired QOL (P = 0.006), were less likely to experience worsening depression (P = 0.0008), and were more likely to have improved QOL (P = 0.003) at their first follow-up evaluation. Changes in QOL measures over time were not found to be associated with survival in multivariable analyses that adjusted for known prognostic variables; variables that were independently associated with improved survival were better performance status (P < 0.001), younger age (P < 0.001), and greater extent of resection (P < 0.001). CONCLUSION: Baseline QOL was predictive of QOL over time. Gross total resection was associated with longer survival and improved QOL over time for patients with high-grade gliomas.

A Prospective Study of Quality of Life in Adults With Newly Diagnosed High-Grade Gliomas

2008 ◽  
Vol 31 (2) ◽  
pp. 163-168 ◽  
Author(s):  
Paul D. Brown ◽  
Paul A. Decker ◽  
Teresa A. Rummans ◽  
Matthew M. Clark ◽  
Marlene H. Frost ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Prospective Study ◽  
High Grade ◽  
Newly Diagnosed ◽  
High Grade Gliomas ◽  
A Prospective Study

Prospective NCCTG quality of life (QOL) study in adult newly diagnosed high-grade gliomas (HGG)

2004 ◽  
Vol 22 (14_suppl) ◽  
pp. 1524-1524
Author(s):  
P. D. Brown ◽  
K. V. Ballman ◽  
T. A. Rummans ◽  
M. J. Maurer ◽  
J. A. Sloan ◽  
...  
Keyword(s):  
Quality Of Life ◽  
High Grade ◽  
Newly Diagnosed ◽  
High Grade Gliomas

Prospective NCCTG quality of life (QOL) study in adult newly diagnosed high-grade gliomas (HGG)

2004 ◽  
Vol 22 (14_suppl) ◽  
pp. 1524-1524
Author(s):  
P. D. Brown ◽  
K. V. Ballman ◽  
T. A. Rummans ◽  
M. J. Maurer ◽  
J. A. Sloan ◽  
...  
Keyword(s):  
Quality Of Life ◽  
High Grade ◽  
Newly Diagnosed ◽  
High Grade Gliomas

Prospective Study of Quality of Life in Adults with Newly Diagnosed High-grade Gliomas

2005 ◽  
Vol 76 (3) ◽  
pp. 283-291 ◽  
Author(s):  
Paul D. Brown ◽  
Karla V. Ballman ◽  
Teresa A. Rummans ◽  
Matthew J. Maurer ◽  
Jeff A. Sloan ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Prospective Study ◽  
High Grade ◽  
Newly Diagnosed ◽  
High Grade Gliomas

scholarly journals THU0460 PHYSICAL FITNESS AND QUALITY OF LIFE IN WOMEN WITH FIBROMYALGIA: LONGITUDINAL ANALYSES FROM THE AL-ÁNDALUS PROJECT

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 466.1-467
Author(s):  
B. Gavilán Carrera ◽  
I. C. Alvarez-Gallardo ◽  
M. Borges Cosic ◽  
A. Soriano Maldonado ◽  
M. Delgado-Fernández ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Physical Fitness ◽  
Physical Function ◽  
Physical Component Summary ◽  
General Health ◽  
Bodily Pain ◽  
Physical Role ◽  
Over Time

Background:Optimizing the highly deteriorated quality of life (QoL) of patients with fibromyalgia is one of the main goals in the management of the disease1. Physical fitness has been identified as a powerful marker of health that is positively related to QoL in this population2, although previous evidence is mainly based on cross-sectional data.Objectives:This study aimed to examine the longitudinal associations (2- and 5-year follow-up) between physical fitness and QoL in women with fibromyalgia.Methods:In this prospective cohort study, women diagnosed with fibromyalgia (age: 51.3±7.6 years) with completed data were included at baseline (n=441), at 2-year follow-up (n=220) and at 5-year follow-up (n=227). The Senior Fitness Tests battery was used to assess physical fitness components and a standardized global fitness index was calculated. The eight dimensions plus the two physical and mental component summaries of the Short-Form health survey-36 questionnaire were used to assess QoL. To examine whether changes in fitness predicted QoL at follow-up, multiple linear regression models were built. The bidirectionallity of the associations (whether changes in QoL predicted fitness at follow-up) was also tested. Outcome values at baseline and age, fat percentage, analgesic consumption, educational level, and occupational status at follow-up were entered as potential confounders in all analyses.Results:Changes in fitness were associated with physical function (β=0.160), physical role (β=0.275), bodily pain (β=0.271), general health (β=0.144), and physical component summary (β=0.276) at 2-year follow-up (all,P<0.05) and with changes in physical role (β=0.215) and physical component summary (β=0.135) at 5-year follow-up (all,P<0.05). Changes in physical function (β=0.165), physical role (β=0.230), bodily pain (β=0.230), general health (β=0.130) and physical summary component (β=0.251) were associated with fitness at 2-year follow-up (all,P<0.05). Changes in all dimensions of QoL (β rating from 0.113 to 0.198), as well as the physical (β=0.174) and mental (β=0.164) summary components were associated with fitness at 5-year follow-up (all,P<0.05).Conclusion:Increasing levels of physical fitness over time predicts future QoL in women with fibromyalgia, especially for physical domains at 2-year follow-up. In addition, increasing QoL across all domains over time predicts future global fitness at 2- and, specially, 5-year follow-up. Future research is warranted to determine the clinical relevance of the bidirectional association between physical fitness and QoL in fibromyalgia.References:[1]Macfarlane GJ, et al. Ann Rheum Dis, 2018; 76(2), 318-328.[2]Álvarez-Gallardo IC, et al. 2019;99:1481–1494.Acknowledgments:This study was supported by the Spanish Ministry of Economy and Competitiveness (I+D+i DEP2010-15639; I+D+I DEP2013-40908-R; BES-2014-067612) and the Spanish Ministry of Education (FPU14/FPU 15/00002)Disclosure of Interests: :None declared

scholarly journals Better health-related quality of life in kidney transplant patients compared to chronic kidney disease patients with similar renal function

PLoS ONE ◽  
2021 ◽  
Vol 16 (10) ◽  
pp. e0257981
Author(s):  
Jung-Hwa Ryu ◽  
Tai Yeon Koo ◽  
Han Ro ◽  
Jang-Hee Cho ◽  
Myung-Gyu Kim ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Health Related Quality ◽  
Sf 36 ◽  
Related Quality ◽  
Health Related ◽  
Over Time

Renal functional deterioration is associated with physical and mental burdens for kidney transplant (KT) and chronic kidney disease (CKD) patients. However, the change in health-related quality of life (HRQOL) over time in KT patients compared to that of native CKD patients has not been evaluated. We addressed this issue using KT patients registered in the KNOW-KT cohort study and patients at CKD stage 1–3 registered in the KNOW-CKD cohort study. HRQOL scores were assessed using the Kidney Disease Quality of Life Short Form at baseline, 2-, and 4-years follow-up in 842 KT patients and at baseline and 5-year follow-up in 1,355 CKD patients. SF-36 scores declined at the 4-year follow-up, whereas CKD-targeted scores showed no change in the KT group. In contrast, CKD-targeted scores as well as SF-36 scores were decreased at the 5-year follow-up in CKD patients. When prognostic factors were analyzed for longitudinal HRQOL data over time, renal functions, diabetes, cardiovascular and cerebrovascular diseases, hemoglobin level, marital status, income, employment, and health care were significant prognostic factors. Furthermore, KT was an independent prognostic factor for better HRQOL. These results highlight that KT can offer a better HRQOL than that of CKD patients, even when renal function is similar.

scholarly journals Quality of Life in Patients with Primary CNS Lymphoma - a Pooled Analysis from Three Prospective Multicentre Trials

Blood ◽  
2016 ◽  
Vol 128 (22) ◽  
pp. 5385-5385
Author(s):  
Benjamin Kasenda ◽  
Gabriele Ihorst ◽  
Heidi Fricker ◽  
Elke Valk ◽  
Elisabeth Schorb ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Health Status ◽  
Multivariable Analysis ◽  
Newly Diagnosed ◽  
Eortc Qlq C30 ◽  
Beta Coefficient ◽  
Relapsed Disease ◽  
Eortc Qlq ◽  
Over Time

Abstract Background Primary CNS lymphoma (PCNSL) is a rare extra nodal non-Hodgkin lymphoma. High-dose methotrexate (HD-MTX) based treatment has improved prognosis, but little is known about the development of quality of life (QoL) during treatment and follow-up from prospective trials. Methods We pooled data from three prospective trials including 225 immunocompetent patients with PCNSL (186 [83%] with newly diagnosed and 39 [17%] with relapsed disease) - all received HD-MTX based polychemotherapy with rituximab. QoL was a pre-specified secondary endpoint in all trials and evaluated using the EORTC QLQ-C30 and EORTC QLQ-BN20 questionnaire at start of treatment, after completion of treatment and during follow-up. We used descriptive statistics to summarize QoL over time. To investigate the development of QoL over time adjusted for age and Karnofsky performance status (KPS), we used multivariable linear regression models with a random effect to account for repeat measurements. We also did two separate analyses for patients with newly diagnosed PCNSL and relapsed disease. Multiple imputations were applied for missing values within a questionnaire, but we did not impute values of questionnaires that were missing completely. We herein report results on the global health status (GHS, item 30 of EORTC QLQ-C30, higher values represent better QoL) and the predominant item of the EORTC QLQ-BN20 (future uncertainty, higher values represent worse QoL). A change of 10% on the respective scale was considered as a clinically meaningful difference (Osoba et al, Eur J Cancer. 2005 Jan;41(2):280-7 and Maringwa et al, Ann Oncol. 2011 Sep;22(9):2107-12). Results The median age and KPS was 62 years (range 20 to 85) and 80% (30% to 100%), respectively, 119 (52%) were female. Before treatment, the median GHS of the EORTC QLQ-C30 was 50 (interquartile range [IQR] 33 to 67) reflecting substantial impaired QoL. After completion of treatment, the median GHS significantly increased by 17 points to a median of 67 (IQR 50 to 71) (P<0.001), which reflects a clinically meaningful difference. This positive effect was consistent in multivariable analysis (beta coefficient 0.37, p<0.001). Patient with a better KPS before starting treatment had a higher chance that their QoL improved over time (beta coefficient 0.26, p=0.0029). There was no difference regarding GHS between patients with newly diagnosed PCNSL or patients with relapsed disease before starting treatment (median GHS both 50). However, in patients with relapsed disease, numerical increase of GHS over time did not reach statistical significance (beta coefficient 0.36, p=0.2185) likely to limited power in the multivariable analysis. The overall development of GHS over time is shown in Figure 1. The dip at months 17 and 18 area is associated with disease relapse. Regarding the EORTC QLQ-BN20 questionnaire, the predominant issue for patients was future uncertainty (median 42, IQR 17 to 67) before starting treatment, which significantly improved after treatment to 25 (IQR 8 to 33) (p<0.001). In multivariable analysis, future uncertainty also improved significantly in separate analyses for patients with newly diagnosed PCNSL (beta coefficient -0.45, p=0.005) and relapsed disease (beta coefficient -0.89, p=0.0049). The overall development of future uncertainty over time is shown in Figure 2. The increase at months 17 and 18 area is associated with disease relapse. Conclusions Patients with newly diagnosed or relapsed PCNSL reported substantial impaired QoL before starting treatment. However, after treatment with HD-MTX based chemotherapy, QoL significantly improved over time and patients were also more confident regarding their future. Results from our analyses provide a reference for future studies on this important issue in the care of patients with PCNSL. At the meeting we will present further analyses and results from all domains of the EORTC QLQ-C30 and EORTC QLQ-BN20 questionnaires. Figure 1 Global Health Status development from the EORTC QLQ-C30 questionnaire (higher values denote better quality of life) Figure 1. Global Health Status development from the EORTC QLQ-C30 questionnaire (higher values denote better quality of life) Figure 2 Future uncertainty from the EORTC QLQ-BN20 questionnaire (lower values denote better quality of life) Figure 2. Future uncertainty from the EORTC QLQ-BN20 questionnaire (lower values denote better quality of life) Disclosures Kasenda: Riemser: Other: Travel Support. Illerhaus:Riemser, Amgen: Honoraria.

Cognitive profile, psychopathological symptoms, and quality of life in newly diagnosed pediatric epilepsy: A six-month, naturalistic follow-up study

2021 ◽  
pp. 106844
Author(s):  
Željka Rogač ◽  
Dejan Stevanović ◽  
Sara Bečanović ◽  
Ljubica Božić ◽  
Aleksandar Dimitrijević ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cognitive Profile ◽  
Pediatric Epilepsy ◽  
Newly Diagnosed ◽  
Psychopathological Symptoms ◽  
Follow Up Study
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