scholarly journals Machine learning classification of cell-specific cardiac enhancers uncovers developmental subnetworks regulating progenitor cell division and cell fate specification

Development ◽  
2014 ◽  
Vol 141 (4) ◽  
pp. 878-888 ◽  
Author(s):  
S. M. Ahmad ◽  
B. W. Busser ◽  
D. Huang ◽  
E. J. Cozart ◽  
S. Michaud ◽  
...  
Keyword(s):  
Machine Learning ◽  
Cell Division ◽  
Cell Fate ◽  
Progenitor Cell ◽  
Cell Fate Specification ◽  
Machine Learning Classification ◽  
Fate Specification

scholarly journals Anxa4 mediated airway progenitor cell migration promotes distal epithelial cell fate specification

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Kewu Jiang ◽  
Zan Tang ◽  
Juan Li ◽  
Fengchao Wang ◽  
Nan Tang
Keyword(s):  
Cell Migration ◽  
Epithelial Cell ◽  
Cell Fate ◽  
Progenitor Cell ◽  
Cell Fate Specification ◽  
Fate Specification

scholarly journals The WTX Tumor Suppressor Regulates Mesenchymal Progenitor Cell Fate Specification

2012 ◽  
Vol 22 (5) ◽  
pp. 1109-1117
Author(s):  
Annie Moisan ◽  
Miguel N. Rivera ◽  
Sutada Lotinun ◽  
Sara Akhavanfard ◽  
Erik J. Coffman ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Cell Fate ◽  
Progenitor Cell ◽  
Mesenchymal Progenitor Cell ◽  
Cell Fate Specification ◽  
Fate Specification

scholarly journals KIF18B is a cell-type specific regulator of spindle orientation in the epidermis

2021 ◽  
pp. mbc.E21-06-0291
Author(s):  
Rebecca S. Moreci ◽  
Terry Lechler
Keyword(s):  
Cell Division ◽  
Hair Follicle ◽  
Cell Fate ◽  
Asymmetric Cell Division ◽  
Microtubule Dynamics ◽  
Spindle Orientation ◽  
Cell Cortex ◽  
Cell Fate Specification ◽  
Cell Fate Decisions ◽  
Fate Specification

Proper spindle orientation is required for asymmetric cell division and the establishment of complex tissue architecture. In the developing epidermis, spindle orientation requires a conserved cortical protein complex of LGN/NuMA/dynein-dynactin. However, how microtubule dynamics are regulated to interact with this machinery and properly position the mitotic spindle is not fully understood. Furthermore, our understanding of the processes that link spindle orientation during asymmetric cell division to cell fate specification in distinct tissue contexts remains incomplete. We report a role for the microtubule catastrophe factor KIF18B in regulating microtubule dynamics to promote spindle orientation in keratinocytes. During mitosis, KIF18B accumulates at the cell cortex, colocalizing with the conserved spindle orientation machinery. In vivo we find that KIF18B is required for oriented cell divisions within the hair placode, the first stage of hair follicle morphogenesis, but is not essential in the interfollicular epidermis. Disrupting spindle orientation in the placode, using mutations in either KIF18B or NuMA, results in aberrant cell fate marker expression of hair follicle progenitor cells. These data functionally link spindle orientation to cell fate decisions during hair follicle morphogenesis. Taken together, our data demonstrate a role for regulated microtubule dynamics in spindle orientation in epidermal cells. This work also highlights the importance of spindle orientation during asymmetric cell division to dictate cell fate specification. [Media: see text] [Media: see text]

scholarly journals rBMP represses Wnt signaling and influences skeletal progenitor cell fate specification during bone repair

2010 ◽  
Vol 25 (6) ◽  
pp. 1196-1207 ◽  
Author(s):  
Steve Minear ◽  
Philipp Leucht ◽  
Samara Miller ◽  
Jill A Helms
Keyword(s):  
Wnt Signaling ◽  
Cell Fate ◽  
Progenitor Cell ◽  
Bone Repair ◽  
Cell Fate Specification ◽  
Fate Specification

scholarly journals The WTX Tumor Suppressor Regulates Mesenchymal Progenitor Cell Fate Specification

2011 ◽  
Vol 20 (5) ◽  
pp. 583-596 ◽  
Author(s):  
Annie Moisan ◽  
Miguel N. Rivera ◽  
Sutada Lotinun ◽  
Sara Akhavanfard ◽  
Erik J. Coffman ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Cell Fate ◽  
Progenitor Cell ◽  
Mesenchymal Progenitor Cell ◽  
Cell Fate Specification ◽  
Fate Specification

scholarly journals KIF18B is a cell-type specific regulator of spindle orientation in the epidermis

2021 ◽  
Author(s):  
Rebecca S. Moreci ◽  
Terry Lechler
Keyword(s):  
Cell Division ◽  
Hair Follicle ◽  
Cell Fate ◽  
Asymmetric Cell Division ◽  
Microtubule Dynamics ◽  
Spindle Orientation ◽  
Cell Cortex ◽  
Cell Fate Specification ◽  
Cell Fate Decisions ◽  
Fate Specification

Proper spindle orientation is required for asymmetric cell division and the establishment of complex tissue architecture. In the developing epidermis, spindle orientation requires a conserved cortical protein complex of LGN/NuMA/dynein-dynactin. However, how microtubule dynamics are regulated to interact with this machinery and properly position the mitotic spindle is not fully understood. Furthermore, our understanding of the processes that link spindle orientation during asymmetric cell division to cell fate specification in distinct tissue contexts remains incomplete. We report a role for the microtubule catastrophe factor KIF18B in regulating microtubule dynamics to promote spindle orientation in keratinocytes. During mitosis, KIF18B accumulates at the cell cortex, colocalizing with the conserved spindle orientation machinery. In vivo we find that KIF18B is required for oriented cell divisions within the hair placode, the first stage of hair follicle morphogenesis, but is not essential in the interfollicular epidermis. Disrupting spindle orientation in the placode, using mutations in either KIF18B or NuMA, results in aberrant cell fate marker expression of hair follicle progenitor cells. These data functionally link spindle orientation to cell fate decisions during hair follicle morphogenesis. Taken together, our data demonstrate a role for regulated microtubule dynamics in spindle orientation in epidermal cells. This work also highlights the importance of spindle orientation during asymmetric cell division to dictate cell fate specification.

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