scholarly journals The C. elegans Mi-2 chromatin-remodelling proteins function in vulval cell fate determination

Development ◽  
2000 ◽  
Vol 127 (24) ◽  
pp. 5277-5284 ◽  
Author(s):  
T. von Zelewsky ◽  
F. Palladino ◽  
K. Brunschwig ◽  
H. Tobler ◽  
A. Hajnal ◽  
...  
Keyword(s):  
Cell Fate ◽  
Central Component ◽  
Cell Fate Determination ◽  
Nurd Complex ◽  
Fate Determination ◽  
C Elegans ◽  
Vulval Precursor Cells ◽  
The Subject ◽  
Biochemical Analyses ◽  
Ras Signalling

The Mi-2 protein is the central component of the recently isolated NuRD nucleosome remodelling and histone deacetylase complex. Although the NuRD complex has been the subject of extensive biochemical analyses, little is known about its biological function. Here we show that the two C. elegans Mi-2 homologues, LET-418 and CHD-3, play essential roles during development. The two proteins possess both shared and unique functions during vulval cell fate determination, including antagonism of the Ras signalling pathway required for vulval cell fate induction and the proper execution of the 2 degrees cell fate of vulval precursor cells, a process under the control of LIN-12 Notch signalling.

scholarly journals mig-5/Dsh controls cell fate determination and cell migration in C. elegans

2006 ◽  
Vol 298 (2) ◽  
pp. 485-497 ◽  
Author(s):  
Timothy Walston ◽  
Chaobo Guo ◽  
Rui Proenca ◽  
Mingfu Wu ◽  
Michael Herman ◽  
...  
Keyword(s):  
Cell Migration ◽  
Cell Fate ◽  
Cell Fate Determination ◽  
Fate Determination ◽  
C Elegans

scholarly journals Logic programming to predict cell fate patterns and retrodict genotypes in organogenesis

2014 ◽  
Vol 11 (98) ◽  
pp. 20140245 ◽  
Author(s):  
Benjamin A. Hall ◽  
Ethan Jackson ◽  
Alex Hajnal ◽  
Jasmin Fisher
Keyword(s):  
Cell Fate ◽  
Formal Analysis ◽  
Cell Fate Determination ◽  
Logic Programs ◽  
Vulval Development ◽  
Analysis Techniques ◽  
C Elegans ◽  
Vulval Precursor Cells ◽  
Powerful Approach ◽  
Temporal And Spatial

Caenorhabditis elegans vulval development is a paradigm system for understanding cell differentiation in the process of organogenesis. Through temporal and spatial controls, the fate pattern of six cells is determined by the competition of the LET-23 and the Notch signalling pathways. Modelling cell fate determination in vulval development using state-based models, coupled with formal analysis techniques, has been established as a powerful approach in predicting the outcome of combinations of mutations. However, computing the outcomes of complex and highly concurrent models can become prohibitive. Here, we show how logic programs derived from state machines describing the differentiation of C. elegans vulval precursor cells can increase the speed of prediction by four orders of magnitude relative to previous approaches. Moreover, this increase in speed allows us to infer, or ‘retrodict’, compatible genomes from cell fate patterns. We exploit this technique to predict highly variable cell fate patterns resulting from dig-1 reduced-function mutations and let-23 mosaics. In addition to the new insights offered, we propose our technique as a platform for aiding the design and analysis of experimental data.

scholarly journals DISTAG/TBCCd1 Is Required for Basal Cell Fate Determination in Ectocarpus

2017 ◽  
Vol 29 (12) ◽  
pp. 3102-3122 ◽  
Author(s):  
Olivier Godfroy ◽  
Toshiki Uji ◽  
Chikako Nagasato ◽  
Agnieszka P. Lipinska ◽  
Delphine Scornet ◽  
...  
Keyword(s):  
Cell Fate ◽  
Basal Cell ◽  
Cell Fate Determination ◽  
Fate Determination
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