Concentration-Dependent Effect of Nerve Growth Factor on Cell Fate Determination of Neural Progenitors

2011 ◽  
Vol 20 (10) ◽  
pp. 1723-1731 ◽  
Author(s):  
Lei Zhang ◽  
Hui Jiang ◽  
Zhengqing Hu
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Cell Fate ◽  
Neural Progenitors ◽  
Cell Fate Determination ◽  
Dependent Effect ◽  
Nerve Growth ◽  
Fate Determination

Neutralization of Nerve Growth Factor Impairs Proliferation and Differentiation of Adult Neural Progenitors in the Subventricular Zone

Stem Cells ◽  
2014 ◽  
Vol 32 (9) ◽  
pp. 2516-2528 ◽  
Author(s):  
Raffaella Scardigli ◽  
Paolo Capelli ◽  
Domenico Vignone ◽  
Rossella Brandi ◽  
Marcello Ceci ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Subventricular Zone ◽  
Neural Progenitors ◽  
Nerve Growth ◽  
Proliferation And Differentiation

scholarly journals Keap1-Nrf2 system regulates cell fate determination of hematopoietic stem cells

2014 ◽  
Vol 19 (3) ◽  
pp. 239-253 ◽  
Author(s):  
Shohei Murakami ◽  
Ritsuko Shimizu ◽  
Paul-Henri Romeo ◽  
Masayuki Yamamoto ◽  
Hozumi Motohashi
Keyword(s):  
Stem Cells ◽  
Hematopoietic Stem Cells ◽  
Cell Fate ◽  
Cell Fate Determination ◽  
Hematopoietic Stem ◽  
Fate Determination

Role of Geminin in cell fate determination of hematopoietic stem cells (HSCs)

2016 ◽  
Vol 104 (3) ◽  
pp. 324-329 ◽  
Author(s):  
Shin’ichiro Yasunaga ◽  
Yoshinori Ohno ◽  
Naoto Shirasu ◽  
Bo Zhang ◽  
Kyoko Suzuki-Takedachi ◽  
...  
Keyword(s):  
Stem Cells ◽  
Hematopoietic Stem Cells ◽  
Cell Fate ◽  
Cell Fate Determination ◽  
Hematopoietic Stem ◽  
Fate Determination

Notch–RBP-J signaling is involved in cell fate determination of marginal zone B cells

10.1038/ni793 ◽  
2002 ◽  
Vol 3 (5) ◽  
pp. 443-450 ◽  
Author(s):  
Kenji Tanigaki ◽  
Hua Han ◽  
Norio Yamamoto ◽  
Kei Tashiro ◽  
Masaya Ikegawa ◽  
...  
Keyword(s):  
B Cells ◽  
Cell Fate ◽  
Marginal Zone ◽  
Cell Fate Determination ◽  
Marginal Zone B Cells ◽  
Fate Determination

scholarly journals MicroRNAs and long noncoding RNAs: new regulators in cell fate determination of mesenchymal stem cells

RSC Advances ◽  
2019 ◽  
Vol 9 (64) ◽  
pp. 37300-37311 ◽  
Author(s):  
Zixiang Wu ◽  
Shujing Liang ◽  
Wenyu Kuai ◽  
Lifang Hu ◽  
Airong Qian
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Cell Fate ◽  
Noncoding Rnas ◽  
Long Noncoding Rnas ◽  
Cell Fate Determination ◽  
Fate Determination ◽  
Recent Advances

The recent advances of miRNAs and lncRNAs in determining the cell fate of MSCs.

scholarly journals Loss of Smad3-Mediated Negative Regulation of Runx2 Activity Leads to an Alteration in Cell Fate Determination

2005 ◽  
Vol 25 (21) ◽  
pp. 9460-9468 ◽  
Author(s):  
Anita Borton Hjelmeland ◽  
Stephen H. Schilling ◽  
Xing Guo ◽  
Darryl Quarles ◽  
Xiao-Fan Wang
Keyword(s):  
Cell Fate ◽  
Dermal Fibroblasts ◽  
Negative Regulation ◽  
Calcium Deposition ◽  
Cell Fate Determination ◽  
Specific Mechanism ◽  
Fate Determination ◽  
Primary Mouse ◽  
Cellular Context

ABSTRACT Runx2 is required for osteoblast differentiation but is expressed in certain nonosteoblastic cells without activating the differentiation process, suggesting that its activity is suppressed through a lineage-specific mechanism. Here we report that primary mouse dermal fibroblasts lacking Smad3 can acquire an osteoblast-like phenotype, including activation of Runx2 activity, expression of osteoblast-specific genes, and calcium deposition. We further show that negative regulation of Runx2 activity by Smad3 in dermal fibroblasts is likely mediated by controlling the expression of Msx2, an antagonist of Runx2 in this cellular context. These data support the presence of a novel mechanism for controlling cell fate determination of mesenchymal lineages by preventing differentiation toward the osteoblastic lineage via negative regulation of Runx2 activity.

Sign in / Sign up

Export Citation Format

Share Document