scholarly journals Wingless promotes EGFR signaling in follicle stem cells to maintain self-renewal

Development ◽  
2018 ◽  
Vol 145 (23) ◽  
pp. dev168716 ◽  
Author(s):  
Rebecca P. Kim-Yip ◽  
Todd G. Nystul
Keyword(s):  
Stem Cells ◽  
Egfr Signaling ◽  
Self Renewal ◽  
Follicle Stem Cells

scholarly journals Integrins control the positioning and proliferation of follicle stem cells in the Drosophila ovary

2008 ◽  
Vol 182 (4) ◽  
pp. 801-815 ◽  
Author(s):  
Alana M. O'Reilly ◽  
Hsiu-Hsiang Lee ◽  
Michael A. Simon
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Adult Stem Cells ◽  
Cell Communication ◽  
Self Renewal ◽  
Ovarian Stem Cells ◽  
Stem Cell Populations ◽  
Integrin Ligand ◽  
Follicle Stem Cells ◽  
Drosophila Ovary

Adult stem cells are maintained in specialized microenvironments called niches, which promote self-renewal and prevent differentiation. In this study, we show that follicle stem cells (FSCs) in the Drosophila melanogaster ovary rely on cues that are distinct from those of other ovarian stem cells to establish and maintain their unique niche. We demonstrate that integrins anchor FSCs to the basal lamina, enabling FSCs to maintain their characteristic morphology and position. Integrin-mediated FSC anchoring is also essential for proper development of differentiating prefollicle cells that arise from asymmetrical FSC divisions. Our results support a model in which FSCs contribute to the formation and maintenance of their own niche by producing the integrin ligand, laminin A (LanA). Together, LanA and integrins control FSC proliferation rates, a role that is separable from their function in FSC anchoring. Importantly, LanA-integrin function is not required to maintain other ovarian stem cell populations, demonstrating that distinct pathways regulate niche–stem cell communication within the same organ.

scholarly journals EGFR signaling promotes self-renewal through the establishment of cell polarity in Drosophila follicle stem cells

eLife ◽  
2014 ◽  
Vol 3 ◽  
Author(s):  
Angela Castanieto ◽  
Michael J Johnston ◽  
Todd G Nystul
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Cell Polarity ◽  
Growth Factor Receptor ◽  
Egfr Signaling ◽  
Epithelial Stem Cells ◽  
Cell Fates ◽  
Liver Kinase B1 ◽  
Follicle Stem Cells ◽  
Drosophila Ovary

Epithelial stem cells divide asymmetrically, such that one daughter replenishes the stem cell pool and the other differentiates. We found that, in the epithelial follicle stem cell (FSC) lineage of the Drosophila ovary, epidermal growth factor receptor (EGFR) signaling functions specifically in the FSCs to promote the unique partially polarized state of the FSC, establish apical–basal polarity throughout the lineage, and promote FSC maintenance in the niche. In addition, we identified a novel connection between EGFR signaling and the cell-polarity regulator liver kinase B1 (LKB1), which indicates that EGFR signals through both the Ras–Raf–MEK–Erk pathway and through the LKB1–AMPK pathway to suppress apical identity. The development of apical–basal polarity is the earliest visible difference between FSCs and their daughters, and our findings demonstrate that the EGFR-mediated regulation of apical–basal polarity is essential for the segregation of stem cell and daughter cell fates.

scholarly journals Distinct Self-Renewal and Differentiation Phases in the Niche of Infrequently Dividing Hair Follicle Stem Cells

2009 ◽  
Vol 5 (3) ◽  
pp. 267-278 ◽  
Author(s):  
Ying V. Zhang ◽  
Janice Cheong ◽  
Nichita Ciapurin ◽  
David J. McDermitt ◽  
Tudorita Tumbar
Keyword(s):  
Stem Cells ◽  
Hair Follicle ◽  
Self Renewal ◽  
Hair Follicle Stem Cells ◽  
Follicle Stem Cells

scholarly journals Interactions between axon-like projections extended by Drosophila Follicle Stem Cells dictate cell fate decisions

2020 ◽  
Author(s):  
Eric H. Lee ◽  
Daniel Zinshteyn ◽  
Melissa Wang ◽  
Jessica Reinach ◽  
Cindy Chau ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cell Fate ◽  
Axon Growth ◽  
Cell Types ◽  
Still Life ◽  
Self Renewal ◽  
Cell Fate Decisions ◽  
Fate Decision ◽  
Tissue Aging ◽  
Follicle Stem Cells

AbstractStem cells cycle between periods of quiescence and proliferation to promote healthy tissue aging. Once proliferation is initiated, mechanisms that control the balance between self-renewal and differentiation must be engaged to ensure maintenance of stem cell pools until the next quiescent cycle occurs. Here, we demonstrate that dynamic axon-like projections extended by Follicle Stem Cells (FSCs) in the Drosophila ovary control the self-renewal-differentiation balance. Known axon growth regulators still life and sickie are necessary and sufficient for FSC projection growth, mediating organization of germline cyst architecture during follicle formation, controlling targeting of projections to FSCs or germ cells, and regulating expression of the cell fate determinants Eyes Absent (Eya) and Castor (Cas). Our results support a model in which FSC projections function similarly to axons, providing structural organization to a dynamic organ while mediating communication between distinct cell types to effect the key cell fate decision to self-renew or differentiate.

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