scholarly journals Metabolic decisions in development and disease

Development ◽  
2021 ◽  
Vol 148 (11) ◽  
Author(s):  
Lluc Mosteiro ◽  
Hanaa Hariri ◽  
Jelle van den Ameele
Keyword(s):  
Gene Expression ◽  
Cell Fate ◽  
Differential Gene Expression ◽  
Intimate Relationships ◽  
Metabolic Pathways ◽  
Signalling Pathways ◽  
Keystone Symposium ◽  
Differential Gene ◽  
Mechanistic Understanding

ABSTRACT The intimate relationships between cell fate and metabolism have long been recognized, but a mechanistic understanding of how metabolic pathways are dynamically regulated during development and disease, how they interact with signalling pathways, and how they affect differential gene expression is only emerging now. We summarize the key findings and the major themes that emerged from the virtual Keystone Symposium ‘Metabolic Decisions in Development and Disease’ held in March 2021.

scholarly journals Defining cell identity beyond the premise of differential gene expression

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Hani Jieun Kim ◽  
Patrick P. L. Tam ◽  
Pengyi Yang
Keyword(s):  
Gene Expression ◽  
Differential Expression ◽  
Cell Fate ◽  
Differential Gene Expression ◽  
Cell Types ◽  
Cell Identity ◽  
Gene Transcripts ◽  
Differential Gene ◽  
Biological Attributes

AbstractIdentifying genes that define cell identity is a requisite step for characterising cell types and cell states and predicting cell fate choices. By far, the most widely used approach for this task is based on differential expression (DE) of genes, whereby the shift of mean expression are used as the primary statistics for identifying gene transcripts that are specific to cell types and states. While DE-based methods are useful for pinpointing genes that discriminate cell types, their reliance on measuring difference in mean expression may not reflect the biological attributes of cell identity genes. Here, we highlight the quest for non-DE methods and provide an overview of these methods and their applications to identify genes that define cell identity and functionality.

scholarly journals Comparative analysis of transcriptomes of different morphological structures of the basidiomycete Lentinus edodes

2020 ◽  
Author(s):  
E. P. Vetchinkina ◽  
V. Yu. Gorshkov ◽  
N. E. Gogoleva ◽  
Yu. V. Gogolev ◽  
V. E. Nikitina
Keyword(s):  
Gene Expression ◽  
Comparative Analysis ◽  
Differential Gene Expression ◽  
Metabolic Pathways ◽  
Lentinus Edodes ◽  
Differential Gene

A comparative analysis of transcriptomes at the vegetative and generative stages of the development of Lentinus edodes basidiomycetes was carried out. The nature of differential gene expression was described, and the activated/repressed metabolic pathways were visualized.

Sign in / Sign up

Export Citation Format

Share Document