Studies in Embryonic and Larval Development in Amphibia

Development ◽  
1959 ◽  
Vol 7 (2) ◽  
pp. 128-145
Author(s):  
Arthur Hughes

In 1913 G. E. Coghill initiated a series of papers on the neuro-embryology of the Urodele Ambystoma with a description of the earliest stages of the motor system of the trunk (Coghill, 1913). His main conclusion is stated early in the paper in these words: The neurones … which establish the earliest contact with the cells of the myotome are found in Amblystoma to be at the same time the neurones of the motor tract in the central nervous system. The primary ventral root fibre is a collateral of the tract cell. (Coghill, 1913, p. 121.) Thirteen years later, among a group of other papers on the developing nervous system of Ambystoma, he returned to this theme, and in a series of examples described the form of the first nerve process within the basal plate of the cord.

Author(s):  
Kohei Shiota

ABSTRACT The organogenesis of the central nervous system (CNS) begins during the third week of development, but its maturation requires a considerably long period of time until after birth. Therefore the developing nervous system is vulnerable to the deleterious effects of environmental factors during the pre- and perinatal periods. In addition, molecular studies have revealed various gene mutations that are responsible for congenital CNS disorders. This chapter provides an overview of the prenatal development of the human brain and spinal cord. How to cite this article Shiota K. Prenatal Development of the Human Central Nervous System, Normal and Abnormal. Donald School J Ultrasound Obstet Gynecol 2015;9(1):61-66.


2017 ◽  
Vol 372 (1718) ◽  
pp. 20160190 ◽  
Author(s):  
Imran Noorani ◽  
R. H. S. Carpenter

The function of the motor system in preventing rather than initiating movement is often overlooked. Not only are its highest levels predominantly, and tonically, inhibitory, but in general behaviour it is often intermittent, characterized by relatively short periods of activity separated by longer periods of stillness: for most of the time we are not moving, but stationary. Furthermore, these periods of immobility are not a matter of inhibition and relaxation, but require us to expend almost as much energy as when we move, and they make just as many demands on the central nervous system in controlling their performance. The mechanisms that stop movement and maintain immobility have been a greatly neglected area of the study of the brain. This paper introduces the topics to be examined in this special issue of Philosophical Transactions , discussing the various types of stopping and stillness, the problems that they impose on the motor system, the kinds of neural mechanism that underlie them and how they can go wrong. This article is part of the themed issue ‘Movement suppression: brain mechanisms for stopping and stillness’.


1979 ◽  
Vol 44 (1) ◽  
pp. 55-60 ◽  
Author(s):  
Craig Linebough

Shy-Drager syndrome is a degenerative disease of the central nervous system that may include among its signs some form of dysarthria. Of 80 patients with Shy-Drager syndrome, 35 presented some form of dysarthria. Of these, 15 presented dysarthria indicative of cerebellar dysfunction, 11 with dysarthria indicating involvement of the striatum, and nine with various mixed dysarthrias indicative of multiple motor system involvement. The results of this study reaffirm the value of assessing motor speech in the differential diagnosis of neuromotor impairments and emphasize the importance of maintaining effective modes of communication for patients having progressive disorders.


1954 ◽  
Vol 100 (420) ◽  
pp. 670-677 ◽  
Author(s):  
M. C. H. Dodgson

In view of the importance of prenatal pathology at the present time, a useful purpose may be served by attempting to review the peculiar weaknesses and strengths of the developing nervous system. As a result of personal inclinations, this presentation of the various problems involved will have a structural bias; the subject would, no doubt, be approached very differently by a physiologist, for instance, or by a biochemist. Nevertheless we should all be describing different aspects of the same series of phenomena, aiming at an understanding of the events which must occur before the central nervous system can function.


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