Guideline Recommended Gastric Cancer Care in the Elderly: Insights into the Applicability of Cancer Trials to Real World

2010 ◽  
Vol 18 (1) ◽  
pp. 26-33 ◽  
Author(s):  
Vikas Dudeja ◽  
Elizabeth B. Habermann ◽  
Wei Zhong ◽  
Todd M. Tuttle ◽  
Selwyn M. Vickers ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Real World ◽  
Cancer Care ◽  
The Elderly ◽  
Cancer Trials

Gastric Cancer Care in the Elderly: Insights into the Generalizability of NCI Cancer Trials

2010 ◽  
Vol 158 (2) ◽  
pp. 242-243
Author(s):  
V. Dudeja ◽  
E.B. Habermann ◽  
W. Zhong ◽  
S.M. Vickers ◽  
T.M. Tuttle ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Care ◽  
The Elderly ◽  
Cancer Trials

scholarly journals Trastuzumab-based palliative chemotherapy for HER2-positive gastric cancer: a single-center real-world data

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Tae-Hwan Kim ◽  
Hun Do Cho ◽  
Yong Won Choi ◽  
Hyun Woo Lee ◽  
Seok Yun Kang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Real World ◽  
Group Performance ◽  
Eastern Cooperative Oncology Group ◽  
Conversion Surgery ◽  
Single Center ◽  
Her2 Positive ◽  
Real World Data ◽  
World Data ◽  
The Real

Abstract Background Since the results of the ToGA trial were published, trastuzumab-based chemotherapy has been used as the standard first-line treatment for HER2-positive recurrent or primary metastatic gastric cancer (RPMGC). However, the real-world data has been rarely reported. Therefore, we investigated the outcomes of trastuzumab-based chemotherapy in a single center. Methods This study analyzed the real-world data of 47 patients with HER2-positive RPMGC treated with trastuzumab-based chemotherapy in a single institution. Results With the median follow-up duration of 18.8 months in survivors, the median overall survival (OS) and progression-free survival were 12.8 and 6.9 months, respectively, and the overall response rate was 64%. Eastern Cooperative Oncology Group performance status 2 and massive amount of ascites were independent poor prognostic factors for OS, while surgical resection before or after chemotherapy was associated with favorable OS, in multivariate analysis. In addition, 5 patients who underwent conversion surgery after chemotherapy demonstrated an encouraging median OS of 30.8 months, all with R0 resection. Conclusions Trastuzumab-based chemotherapy in patients with HER2-positive RPMGC in the real world demonstrated outcomes almost comparable to those of the ToGA trial. Moreover, conversion surgery can be actively considered in fit patients with a favorable response after trastuzumab-based chemotherapy.

scholarly journals Hobbit: Providing Fall Detection and Prevention for the Elderly in the Real World

2018 ◽  
Vol 2018 ◽  
pp. 1-20 ◽  
Author(s):  
Markus Bajones ◽  
David Fischinger ◽  
Astrid Weiss ◽  
Daniel Wolf ◽  
Markus Vincze ◽  
...  
Keyword(s):  
Real World ◽  
Independent Living ◽  
Low Cost ◽  
Fall Detection ◽  
The Elderly ◽  
Field Trials ◽  
Lessons Learned ◽  
Human Robot Interaction ◽  
Service Robot ◽  
Emergency Situations

We present the robot developed within the Hobbit project, a socially assistive service robot aiming at the challenge of enabling prolonged independent living of elderly people in their own homes. We present the second prototype (Hobbit PT2) in terms of hardware and functionality improvements following first user studies. Our main contribution lies within the description of all components developed within the Hobbit project, leading to autonomous operation of 371 days during field trials in Austria, Greece, and Sweden. In these field trials, we studied how 18 elderly users (aged 75 years and older) lived with the autonomously interacting service robot over multiple weeks. To the best of our knowledge, this is the first time a multifunctional, low-cost service robot equipped with a manipulator was studied and evaluated for several weeks under real-world conditions. We show that Hobbit’s adaptive approach towards the user increasingly eased the interaction between the users and Hobbit. We provide lessons learned regarding the need for adaptive behavior coordination, support during emergency situations, and clear communication of robotic actions and their consequences for fellow researchers who are developing an autonomous, low-cost service robot designed to interact with their users in domestic contexts. Our trials show the necessity to move out into actual user homes, as only there can we encounter issues such as misinterpretation of actions during unscripted human-robot interaction.

scholarly journals Large Scale, Multicenter, Prospective Study of Apatinib in Advanced Gastric Cancer: A Real-World Study from China [Corrigendum]

2020 ◽  
Vol Volume 12 ◽  
pp. 8409-8410
Author(s):  
Wanren Peng ◽  
Fenglin Zhang ◽  
Zishu Wang ◽  
Dongliang Li ◽  
Yifu He ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Prospective Study ◽  
Advanced Gastric Cancer ◽  
Real World ◽  
Large Scale ◽  
Multicenter Prospective Study

Second-line treatment efficacy and toxicity in older vs. non-older patients with advanced gastric cancer: A multicentre real-world study

2019 ◽  
Vol 10 (4) ◽  
pp. 591-597 ◽  
Author(s):  
Valentina Fanotto ◽  
Lorenzo Fornaro ◽  
Roberto Bordonaro ◽  
Gerardo Rosati ◽  
Lorenza Rimassa ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Advanced Gastric Cancer ◽  
Real World ◽  
Treatment Efficacy ◽  
Older Patients ◽  
Line Treatment ◽  
Second Line

scholarly journals Survival Based On The Pathologic Lymph Node Ratio For Local Advanced Gastric Cancer; Elderly Patients Versus Non Elderly Patients

2021 ◽  
Author(s):  
Omer Yalkin ◽  
Nidal Iflazoglu ◽  
Olgun Deniz ◽  
Mustafa Yener Uzunoglu ◽  
Ezgi Isil Turhan
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Elderly Patients ◽  
Advanced Gastric Cancer ◽  
Lymph Node Ratio ◽  
Locally Advanced ◽  
Survival Rates ◽  
The Elderly ◽  
Survival Difference ◽  
Node Ratio

Abstract Objective: The aim of this study was to clarify the prognostic value of the pathological lymph node ratio for elderly and non-elderly gastric cancer patients and to evaluate whether there is a difference in the survival of patients with the same LNR (Lymph Node Ratio).Materials and Methods: A total of 222 patients diagnosed with locally advanced gastric cancer and who underwent gastrectomy were included. The patients were divided into two groups according to age. Clinicopathological properties of the two groups were compared. Potential prognostic factors affecting survival were analyzed. Subsequently, the effect of lymphadenectomy and LNR on survival in both groups was evaluated. Results: Significant differences were detected in terms of the location of primary lesions, hemoglobin and albumin levels between elderly patients and non-elderly patients (p < .05). Overall survival (OS) was significantly worse in elderly patients (22 months vs. 67 months, p<0.001). The survival rates in elderly patients were significantly lower from those of non-elderly in the subgroup LNR Stage 2 (12.1% vs. 47.9 %, P = 0.004) and LNR Stage 3 classification (9.1% vs. 34.1%, P = 0.039). LNR was found to be significant for OS with a cut-off point of 0.18. Conclusion: A survival difference was found between the elderly and non-elderly patients with the same LNR. LNR was found to be an independent factor for survival especially in elderly patients. Survival was found to be further decreased in elderly patients compared to non-elderly patients with increasing LNR.

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